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Mechanistic and therapeutic implications of EphA‐4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.

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Title: Mechanistic and therapeutic implications of EphA‐4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.
Authors: Ganguly, Devargya (AUTHOR), Thomas, Joshua Abby (AUTHOR), Ali, Abid (AUTHOR), Kumar, Rahul (AUTHOR)
Source: European Journal of Neuroscience. Nov2022, Vol. 56 Issue 9, p5532-5546. 15p. 1 Diagram, 1 Chart.
Subjects: Alzheimer's disease, Kinases, Protein-tyrosine kinases, Apolipoprotein E4, Peptides, Neural development, Pathogenesis
Abstract: Erythropoietin‐producing hepatoma (Eph) receptors belong to a family of tyrosine kinase receptors that plays a pivotal role in the development of the brain. Eph can be divided broadly into two groups, namely, EphA and EphB, comprising nine and five members, respectively. In recent years, the role of EphA‐4 has become increasingly apparent in the onset of Alzheimer's disease (AD). Emerging evidence suggests that EphA‐4 results in synaptic dysfunction, which in turn promotes the progression of AD. Moreover, pharmacological or genetic ablation of EphA‐4 in the murine model of AD can alleviate the symptoms. The current review summarizes different pathways by which EphA‐4 can influence pathogenesis. Since, majority of the studies had reported the protective effect of EphA‐4 inhibition during AD, designing therapeutics based on decreasing its enzymatic activity might be necessary for introducing the novel interventions. Therefore, the review described peptide and nanobodies inhibitors of EphA‐4 that exhibit the potential to modulate EphA‐4 and could be used as lead molecules for the targeted therapy of AD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Mechanistic and therapeutic implications of EphA‐4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ganguly%2C+Devargya%22">Ganguly, Devargya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomas%2C+Joshua+Abby%22">Thomas, Joshua Abby</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Abid%22">Ali, Abid</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumar%2C+Rahul%22">Kumar, Rahul</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2022, Vol. 56 Issue 9, p5532-5546. 15p. 1 Diagram, 1 Chart.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Kinases%22">Kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Protein-tyrosine+kinases%22">Protein-tyrosine kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Apolipoprotein+E4%22">Apolipoprotein E4</searchLink><br /><searchLink fieldCode="DE" term="%22Peptides%22">Peptides</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Pathogenesis%22">Pathogenesis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Erythropoietin‐producing hepatoma (Eph) receptors belong to a family of tyrosine kinase receptors that plays a pivotal role in the development of the brain. Eph can be divided broadly into two groups, namely, EphA and EphB, comprising nine and five members, respectively. In recent years, the role of EphA‐4 has become increasingly apparent in the onset of Alzheimer's disease (AD). Emerging evidence suggests that EphA‐4 results in synaptic dysfunction, which in turn promotes the progression of AD. Moreover, pharmacological or genetic ablation of EphA‐4 in the murine model of AD can alleviate the symptoms. The current review summarizes different pathways by which EphA‐4 can influence pathogenesis. Since, majority of the studies had reported the protective effect of EphA‐4 inhibition during AD, designing therapeutics based on decreasing its enzymatic activity might be necessary for introducing the novel interventions. Therefore, the review described peptide and nanobodies inhibitors of EphA‐4 that exhibit the potential to modulate EphA‐4 and could be used as lead molecules for the targeted therapy of AD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.15591
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 5532
    Subjects:
      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Kinases
        Type: general
      – SubjectFull: Protein-tyrosine kinases
        Type: general
      – SubjectFull: Apolipoprotein E4
        Type: general
      – SubjectFull: Peptides
        Type: general
      – SubjectFull: Neural development
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      – SubjectFull: Pathogenesis
        Type: general
    Titles:
      – TitleFull: Mechanistic and therapeutic implications of EphA‐4 receptor tyrosine kinase in the pathogenesis of Alzheimer's disease.
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            NameFull: Ganguly, Devargya
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            NameFull: Thomas, Joshua Abby
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            NameFull: Ali, Abid
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            NameFull: Kumar, Rahul
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            – D: 01
              M: 11
              Text: Nov2022
              Type: published
              Y: 2022
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