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Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.

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Title: Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.
Authors: Shell, Aubrey L., Williams, Michelle K., Patel, Jay S., Vrany, Elizabeth A., Considine, Robert V., Acton, Anthony J., Stewart, Jesse C.
Source: Journal of Behavioral Medicine. Dec2022, Vol. 45 Issue 6, p882-893. 12p. 1 Diagram, 2 Charts.
Subjects: C-reactive protein, Hyperphagia, Black people, Systemic inflammatory response syndrome, Primary health care, Hypersomnia, Mental depression, Descriptive statistics, Somatoform disorders, Body mass index, White people, Data analysis software, Insulin resistance
Abstract: The somatic depressive symptom cluster (including appetite and sleep disturbances) is more strongly associated with insulin resistance (a diabetes risk marker) than other depressive symptom clusters. Utilizing baseline data from 129 primary care patients with depression but no diabetes in the eIMPACT trial (Mage = 59 years, 78% female, 50% Black), we examined associations of somatic depressive symptoms with insulin resistance (HOMA-IR), body mass index (BMI), and high-sensitivity C-reactive protein (hsCRP). We tested BMI and hsCRP as mediators and race as a moderator of these relationships. Hyperphagia was positively associated HOMA-IR (β = 0.19, p =.048) and BMI (β = 0.30, p <.001); poor appetite was negatively associated with HOMA-IR (β = -0.24, p =.02); hypersomnia was positively associated with HOMA-IR (β = 0.28, p =.003), BMI (β = 0.26, p =.003), and hsCRP (β = 0.23, p =.01); and disturbed sleep was positively associated with hsCRP (β = 0.21, p =.04). BMI partially mediated hyperphagia and hypersomnia's associations with HOMA-IR; hsCRP partially mediated the hypersomnia-HOMA-IR association; and race moderated the hyperphagia-HOMA-IR association (positive for White participants but null for Black participants). People with depression experiencing hyperphagia and/or hypersomnia may be a subgroup with greater insulin resistance; BMI and hsCRP are likely pathways in these relationships. This study highlights the importance of considering the direction of somatic depressive symptoms in the context of cardiometabolic disease risk. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Behavioral Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shell%2C+Aubrey+L%2E%22&quot;&gt;Shell, Aubrey L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Williams%2C+Michelle+K%2E%22&quot;&gt;Williams, Michelle K.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Patel%2C+Jay+S%2E%22&quot;&gt;Patel, Jay S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vrany%2C+Elizabeth+A%2E%22&quot;&gt;Vrany, Elizabeth A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Considine%2C+Robert+V%2E%22&quot;&gt;Considine, Robert V.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Acton%2C+Anthony+J%2E%22&quot;&gt;Acton, Anthony J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stewart%2C+Jesse+C%2E%22&quot;&gt;Stewart, Jesse C.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Behavioral+Medicine%22&quot;&gt;Journal of Behavioral Medicine&lt;/searchLink&gt;. Dec2022, Vol. 45 Issue 6, p882-893. 12p. 1 Diagram, 2 Charts.
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  Data: The somatic depressive symptom cluster (including appetite and sleep disturbances) is more strongly associated with insulin resistance (a diabetes risk marker) than other depressive symptom clusters. Utilizing baseline data from 129 primary care patients with depression but no diabetes in the eIMPACT trial (Mage = 59 years, 78% female, 50% Black), we examined associations of somatic depressive symptoms with insulin resistance (HOMA-IR), body mass index (BMI), and high-sensitivity C-reactive protein (hsCRP). We tested BMI and hsCRP as mediators and race as a moderator of these relationships. Hyperphagia was positively associated HOMA-IR (β = 0.19, p =.048) and BMI (β = 0.30, p &lt;.001); poor appetite was negatively associated with HOMA-IR (β = -0.24, p =.02); hypersomnia was positively associated with HOMA-IR (β = 0.28, p =.003), BMI (β = 0.26, p =.003), and hsCRP (β = 0.23, p =.01); and disturbed sleep was positively associated with hsCRP (β = 0.21, p =.04). BMI partially mediated hyperphagia and hypersomnia&#39;s associations with HOMA-IR; hsCRP partially mediated the hypersomnia-HOMA-IR association; and race moderated the hyperphagia-HOMA-IR association (positive for White participants but null for Black participants). People with depression experiencing hyperphagia and/or hypersomnia may be a subgroup with greater insulin resistance; BMI and hsCRP are likely pathways in these relationships. This study highlights the importance of considering the direction of somatic depressive symptoms in the context of cardiometabolic disease risk. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Behavioral Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10865-022-00356-9
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      – Code: eng
        Text: English
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        PageCount: 12
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    Subjects:
      – SubjectFull: C-reactive protein
        Type: general
      – SubjectFull: Hyperphagia
        Type: general
      – SubjectFull: Black people
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      – SubjectFull: Systemic inflammatory response syndrome
        Type: general
      – SubjectFull: Primary health care
        Type: general
      – SubjectFull: Hypersomnia
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      – SubjectFull: Mental depression
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      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Somatoform disorders
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      – SubjectFull: Body mass index
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      – SubjectFull: Data analysis software
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      – SubjectFull: Insulin resistance
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      – TitleFull: Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.
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              Text: Dec2022
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              Y: 2022
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