View in EDS

Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features.

Saved in:
Bibliographic Details
Title: Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features.
Authors: Karpf, Julian (AUTHOR), Unichenko, Petr (AUTHOR), Chalmers, Nicholas (AUTHOR), Beyer, Felix (AUTHOR), Wittmann, Marie-Theres (AUTHOR), Schneider, Julia (AUTHOR), Fidan, Elif (AUTHOR), Reis, Andre (AUTHOR), Beckervordersandforth, Jan (AUTHOR), Brandner, Sebastian (AUTHOR), Liebner, Stefan (AUTHOR), Falk, Sven (AUTHOR), Sagner, Andreas (AUTHOR), Henneberger, Christian (AUTHOR), Beckervordersandforth, Ruth (AUTHOR)
Source: Nature Neuroscience. Dec2022, Vol. 25 Issue 12, p1626-1638. 13p.
Abstract: Neuronal heterogeneity has been established as a pillar of higher central nervous system function, but glial heterogeneity and its implications for neural circuit function are poorly understood. Here we show that the adult mouse dentate gyrus (DG) of the hippocampus is populated by molecularly distinct astrocyte subtypes that are associated with distinct DG layers. Astrocytes localized to different DG compartments also exhibit subtype-specific morphologies. Physiologically, astrocytes in upper DG layers form large syncytia, while those in lower DG compartments form smaller networks. Astrocyte subtypes differentially express glutamate transporters, which is associated with different amplitudes of glutamate transporter-mediated currents. Key molecular and morphological features of astrocyte diversity in the mice DG are conserved in humans. This adds another layer of complexity to our understanding of brain network composition and function, which will be crucial for further studies on astrocytes in health and disease. Karpf et al. showed that distinct layers of the adult human and mouse DG are populated by astrocytes, which exhibit a subtype-specific molecular profile and morphology, leading to subtype-specific physiological characteristics. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 160480947
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Karpf%2C+Julian%22">Karpf, Julian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Unichenko%2C+Petr%22">Unichenko, Petr</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chalmers%2C+Nicholas%22">Chalmers, Nicholas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beyer%2C+Felix%22">Beyer, Felix</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wittmann%2C+Marie-Theres%22">Wittmann, Marie-Theres</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schneider%2C+Julia%22">Schneider, Julia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fidan%2C+Elif%22">Fidan, Elif</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reis%2C+Andre%22">Reis, Andre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beckervordersandforth%2C+Jan%22">Beckervordersandforth, Jan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brandner%2C+Sebastian%22">Brandner, Sebastian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liebner%2C+Stefan%22">Liebner, Stefan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Falk%2C+Sven%22">Falk, Sven</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sagner%2C+Andreas%22">Sagner, Andreas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Henneberger%2C+Christian%22">Henneberger, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beckervordersandforth%2C+Ruth%22">Beckervordersandforth, Ruth</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Dec2022, Vol. 25 Issue 12, p1626-1638. 13p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Neuronal heterogeneity has been established as a pillar of higher central nervous system function, but glial heterogeneity and its implications for neural circuit function are poorly understood. Here we show that the adult mouse dentate gyrus (DG) of the hippocampus is populated by molecularly distinct astrocyte subtypes that are associated with distinct DG layers. Astrocytes localized to different DG compartments also exhibit subtype-specific morphologies. Physiologically, astrocytes in upper DG layers form large syncytia, while those in lower DG compartments form smaller networks. Astrocyte subtypes differentially express glutamate transporters, which is associated with different amplitudes of glutamate transporter-mediated currents. Key molecular and morphological features of astrocyte diversity in the mice DG are conserved in humans. This adds another layer of complexity to our understanding of brain network composition and function, which will be crucial for further studies on astrocytes in health and disease. Karpf et al. showed that distinct layers of the adult human and mouse DG are populated by astrocytes, which exhibit a subtype-specific molecular profile and morphology, leading to subtype-specific physiological characteristics. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=160480947
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41593-022-01192-5
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 1626
    Titles:
      – TitleFull: Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Karpf, Julian
      – PersonEntity:
          Name:
            NameFull: Unichenko, Petr
      – PersonEntity:
          Name:
            NameFull: Chalmers, Nicholas
      – PersonEntity:
          Name:
            NameFull: Beyer, Felix
      – PersonEntity:
          Name:
            NameFull: Wittmann, Marie-Theres
      – PersonEntity:
          Name:
            NameFull: Schneider, Julia
      – PersonEntity:
          Name:
            NameFull: Fidan, Elif
      – PersonEntity:
          Name:
            NameFull: Reis, Andre
      – PersonEntity:
          Name:
            NameFull: Beckervordersandforth, Jan
      – PersonEntity:
          Name:
            NameFull: Brandner, Sebastian
      – PersonEntity:
          Name:
            NameFull: Liebner, Stefan
      – PersonEntity:
          Name:
            NameFull: Falk, Sven
      – PersonEntity:
          Name:
            NameFull: Sagner, Andreas
      – PersonEntity:
          Name:
            NameFull: Henneberger, Christian
      – PersonEntity:
          Name:
            NameFull: Beckervordersandforth, Ruth
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 10976256
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 12
          Titles:
            – TitleFull: Nature Neuroscience
              Type: main
ResultId 1