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Metabolic and clinical profiles of young people with mood or psychotic disorders who are prescribed metformin in an inpatient setting.

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Title: Metabolic and clinical profiles of young people with mood or psychotic disorders who are prescribed metformin in an inpatient setting.
Authors: Wilson, Chloe (AUTHOR), Carpenter, Joanne (AUTHOR), Park, Shinho (AUTHOR), McHugh, Catherine (AUTHOR), Scott, Elizabeth M (AUTHOR), Hickie, Ian B (AUTHOR)
Source: Australasian Psychiatry. Dec2022, Vol. 30 Issue 6, p689-693. 5p.
Subjects: Young adults, Psychoses, Affective disorders, Metformin, Body mass index
Abstract: Objective: Youth with early-onset mood or psychotic disorders are occasionally prescribed metformin to manage cardiometabolic risk. This retrospective study explores the demographic, clinical and metabolic factors associated with metformin prescription youth with mood or psychotic disorders. Method: Participants included 72 youth with mood or psychotic disorders from a young adult mental health inpatient unit, of which 18 (33%) were newly prescribed metformin, and 54 (66%) were not prescribed metformin. Demographic and clinical information were extracted from the patients' medical files along with body mass index (BMI), fasting serum bloods and calculated updated homeostatic model of insulin resistance assessment (HOMA2-IR) scores to compare profiles between groups. Results: Of those prescribed metformin, 83% were overweight or obese and 72% had elevated HOMA2-IR scores. Of those not receiving metformin treatment, 41% were overweight or obese and 22% had elevated HOMA2-IR scores. Youth prescribed metformin had significantly higher BMI, and elevated markers of insulin resistance, but did not differ to those not prescribed metformin on other demographic, clinical or metabolic factors. Conclusions: While metformin is prescribed to some youth with mood or psychotic disorders displaying markers of cardiometabolic disturbance, there is a need to develop clearer treatment guidelines for metformin in these youth. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Metabolic and clinical profiles of young people with mood or psychotic disorders who are prescribed metformin in an inpatient setting.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Wilson%2C+Chloe%22">Wilson, Chloe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carpenter%2C+Joanne%22">Carpenter, Joanne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Shinho%22">Park, Shinho</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McHugh%2C+Catherine%22">McHugh, Catherine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scott%2C+Elizabeth+M%22">Scott, Elizabeth M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hickie%2C+Ian+B%22">Hickie, Ian B</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Dec2022, Vol. 30 Issue 6, p689-693. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Young+adults%22">Young adults</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Metformin%22">Metformin</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Youth with early-onset mood or psychotic disorders are occasionally prescribed metformin to manage cardiometabolic risk. This retrospective study explores the demographic, clinical and metabolic factors associated with metformin prescription youth with mood or psychotic disorders. Method: Participants included 72 youth with mood or psychotic disorders from a young adult mental health inpatient unit, of which 18 (33%) were newly prescribed metformin, and 54 (66%) were not prescribed metformin. Demographic and clinical information were extracted from the patients' medical files along with body mass index (BMI), fasting serum bloods and calculated updated homeostatic model of insulin resistance assessment (HOMA2-IR) scores to compare profiles between groups. Results: Of those prescribed metformin, 83% were overweight or obese and 72% had elevated HOMA2-IR scores. Of those not receiving metformin treatment, 41% were overweight or obese and 22% had elevated HOMA2-IR scores. Youth prescribed metformin had significantly higher BMI, and elevated markers of insulin resistance, but did not differ to those not prescribed metformin on other demographic, clinical or metabolic factors. Conclusions: While metformin is prescribed to some youth with mood or psychotic disorders displaying markers of cardiometabolic disturbance, there is a need to develop clearer treatment guidelines for metformin in these youth. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1177/10398562221115607
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 689
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        Type: general
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Affective disorders
        Type: general
      – SubjectFull: Metformin
        Type: general
      – SubjectFull: Body mass index
        Type: general
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      – TitleFull: Metabolic and clinical profiles of young people with mood or psychotic disorders who are prescribed metformin in an inpatient setting.
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            NameFull: Wilson, Chloe
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            NameFull: Carpenter, Joanne
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            NameFull: Park, Shinho
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            NameFull: Hickie, Ian B
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            – D: 01
              M: 12
              Text: Dec2022
              Type: published
              Y: 2022
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              Value: 30
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