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More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.

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Title: More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.
Authors: Sollenberger, Nathan A., Sequeira, Stefanie, Forbes, Erika E., Siegle, Greg J., Silk, Jennifer S., Ladouceur, Cecile D., Ryan, Neal D., Dahl, Ronald E., Mattfeld, Aaron T., McMakin, Dana L.
Source: Journal of Child Psychology & Psychiatry. Jan2023, Vol. 64 Issue 1, p83-90. 8p. 1 Color Photograph, 2 Charts, 1 Graph.
Subjects: Cross-sectional method, Mental health, Sleep disorders, Randomized controlled trials, Anxiety, Statistical sampling
Abstract: Background: Poor sleep and anxiety disorders are highly comorbid in youth, and each predicts altered ventral striatum (VS) response to rewards, which may impact mental health risk. Contrasting evidence suggests previously reported negative associations between sleep health and VS response may be stronger or weaker in youth with anxiety, indicating sensitivity to win/loss information or blunted reward processing, respectively. We cross‐sectionally examined the role of sleep in VS response to rewards among youth with anxiety versus a no‐psychiatric‐diagnosis comparison (ND) group. We expected a group*sleep interaction on VS response to rewards but did not hypothesize directionality. Methods: As part of the pretreatment battery for a randomized clinical trial, 74 youth with anxiety and 31 ND youth (ages 9–14 years; n = 55 female) completed a monetary reward task during fMRI. During the same pretreatment window, actigraphy and diary‐estimated sleep were collected over 5 days, and participants and their parents each reported participants' total sleep problems. We examined group*sleep interactions on VS response to monetary rewards versus losses via three mixed linear models corresponding to actigraphy, diary, and questionnaires, respectively. Results: Each model indicated group*sleep interactions on VS response to rewards. Actigraphy and diary‐estimated time awake after sleep onset predicted reduced VS response in youth with anxiety but not ND youth. Parent‐reported sleep problems similarly interacted with group, but simple slopes were nonsignificant. Conclusions: Wake after sleep onset was associated with blunted reward response in youth with anxiety. These data suggest a potential pathway through which sleep could contribute to perturbed reward function and reward‐related psychopathology (e.g., depression) in youth with anxiety. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety.
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  Data: <searchLink fieldCode="AR" term="%22Sollenberger%2C+Nathan+A%2E%22">Sollenberger, Nathan A.</searchLink><br /><searchLink fieldCode="AR" term="%22Sequeira%2C+Stefanie%22">Sequeira, Stefanie</searchLink><br /><searchLink fieldCode="AR" term="%22Forbes%2C+Erika+E%2E%22">Forbes, Erika E.</searchLink><br /><searchLink fieldCode="AR" term="%22Siegle%2C+Greg+J%2E%22">Siegle, Greg J.</searchLink><br /><searchLink fieldCode="AR" term="%22Silk%2C+Jennifer+S%2E%22">Silk, Jennifer S.</searchLink><br /><searchLink fieldCode="AR" term="%22Ladouceur%2C+Cecile+D%2E%22">Ladouceur, Cecile D.</searchLink><br /><searchLink fieldCode="AR" term="%22Ryan%2C+Neal+D%2E%22">Ryan, Neal D.</searchLink><br /><searchLink fieldCode="AR" term="%22Dahl%2C+Ronald+E%2E%22">Dahl, Ronald E.</searchLink><br /><searchLink fieldCode="AR" term="%22Mattfeld%2C+Aaron+T%2E%22">Mattfeld, Aaron T.</searchLink><br /><searchLink fieldCode="AR" term="%22McMakin%2C+Dana+L%2E%22">McMakin, Dana L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Jan2023, Vol. 64 Issue 1, p83-90. 8p. 1 Color Photograph, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink>
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  Data: Background: Poor sleep and anxiety disorders are highly comorbid in youth, and each predicts altered ventral striatum (VS) response to rewards, which may impact mental health risk. Contrasting evidence suggests previously reported negative associations between sleep health and VS response may be stronger or weaker in youth with anxiety, indicating sensitivity to win/loss information or blunted reward processing, respectively. We cross‐sectionally examined the role of sleep in VS response to rewards among youth with anxiety versus a no‐psychiatric‐diagnosis comparison (ND) group. We expected a group*sleep interaction on VS response to rewards but did not hypothesize directionality. Methods: As part of the pretreatment battery for a randomized clinical trial, 74 youth with anxiety and 31 ND youth (ages 9–14 years; n = 55 female) completed a monetary reward task during fMRI. During the same pretreatment window, actigraphy and diary‐estimated sleep were collected over 5 days, and participants and their parents each reported participants' total sleep problems. We examined group*sleep interactions on VS response to monetary rewards versus losses via three mixed linear models corresponding to actigraphy, diary, and questionnaires, respectively. Results: Each model indicated group*sleep interactions on VS response to rewards. Actigraphy and diary‐estimated time awake after sleep onset predicted reduced VS response in youth with anxiety but not ND youth. Parent‐reported sleep problems similarly interacted with group, but simple slopes were nonsignificant. Conclusions: Wake after sleep onset was associated with blunted reward response in youth with anxiety. These data suggest a potential pathway through which sleep could contribute to perturbed reward function and reward‐related psychopathology (e.g., depression) in youth with anxiety. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/jcpp.13669
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              Text: Jan2023
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