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Clonazepam for the management of sleep disorders.

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Title: Clonazepam for the management of sleep disorders.
Authors: Raggi, Alberto (AUTHOR), Mogavero, Maria Paola (AUTHOR), DelRosso, Lourdes M. (AUTHOR), Ferri, Raffaele (AUTHOR)
Source: Neurological Sciences. Jan2023, Vol. 44 Issue 1, p115-128. 14p. 2 Diagrams, 3 Charts.
Subjects: Bruxism, Sleep disorders, Sleep latency, Restless legs syndrome, Clonazepam, Random effects model
Abstract: Background: The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals. Methods: A review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index. Results: A total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review; among the latter, nine met the criteria for meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A clear sleep-promoting effect of clonazepam was found also by meta-analysis. Discussion and conclusions: Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Clonazepam for the management of sleep disorders.
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  Data: <searchLink fieldCode="AR" term="%22Raggi%2C+Alberto%22">Raggi, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mogavero%2C+Maria+Paola%22">Mogavero, Maria Paola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22DelRosso%2C+Lourdes+M%2E%22">DelRosso, Lourdes M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferri%2C+Raffaele%22">Ferri, Raffaele</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jan2023, Vol. 44 Issue 1, p115-128. 14p. 2 Diagrams, 3 Charts.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Bruxism%22">Bruxism</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+latency%22">Sleep latency</searchLink><br /><searchLink fieldCode="DE" term="%22Restless+legs+syndrome%22">Restless legs syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Clonazepam%22">Clonazepam</searchLink><br /><searchLink fieldCode="DE" term="%22Random+effects+model%22">Random effects model</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The objectives of this review and meta-analysis of polysomnographic data are those to focus on the clinical use of clonazepam for the management of sleep disorders by re-analyzing clinical trials and randomized clinical trials which have been published in peer-reviewed journals. Methods: A review of the literature including clinical trials and randomized controlled trials was performed in PubMed®, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement protocol. A random effects model meta-analysis was then carried out for the four more frequently reported polysomnographic measures: total sleep time, sleep latency, sleep efficiency, and periodic leg movement during sleep (PLMS) index. Results: A total of 33 articles were retrieved and screened in full text, of which 18 met the criteria for review; among the latter, nine met the criteria for meta-analysis. The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam. A clear sleep-promoting effect of clonazepam was found also by meta-analysis. Discussion and conclusions: Our results indicate that the pharmacological treatment of sleep disorders with clonazepam must always be personalized according to the type of patient, the risk of addiction and the concomitant presence of respiratory disorders are key factors to take into account. However, in light of the clinical evidence of the few studies in the literature on the different types of disorders, more studies on the use of clonazepam (also in association with first choice treatments) are definitely needed. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-022-06397-x
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        Text: English
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        Type: general
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      – SubjectFull: Sleep latency
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              Text: Jan2023
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              Y: 2023
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