View in EDS

Effectiveness of cognitive remediation in depression: a meta-analysis.

Saved in:
Bibliographic Details
Title: Effectiveness of cognitive remediation in depression: a meta-analysis.
Authors: Legemaat, Amanda M., Semkovska, Maria, Brouwer, Marlies, Geurtsen, Gert J., Burger, Huibert, Denys, Damiaan, Bockting, Claudi L.
Source: Psychological Medicine. Dec2022, Vol. 52 Issue 16, p4146-4161. 16p.
Subjects: Prevention of psychological stress, Disease relapse prevention, Online information services, Psychology information storage & retrieval systems, Medical databases, Meta-analysis, Medical information storage & retrieval systems, Confidence intervals, Systematic reviews, Mild cognitive impairment, Treatment effectiveness, Functional assessment, Mental depression, Cognitive remediation, MEDLINE
Abstract: Background: Preliminary evidence suggests beneficial effects of cognitive remediation in depression. An update of the current evidence is needed. The aim was to systematically assess the effectiveness of cognitive remediation in depression on three outcomes. Methods: The meta-analysis was pre-registered on PROSPERO (CRD42019124316). PubMed, PsycINFO, Embase and Cochrane Library were searched on 2 February 2019 and 8 November 2020 for peer-reviewed published articles. We included randomized and non-randomized clinical trials comparing cognitive remediation to control conditions in adults with primary depression. Random-effects models were used to calculate Hedges' g , and moderators were assessed using mixed-effects subgroup analyses and meta-regression. Main outcome categories were post-treatment depressive symptomatology (DS), cognitive functioning (CF) and daily functioning (DF). Results: We identified 5221 records and included 21 studies reporting on 24 comparisons, with 438 depressed patients receiving cognitive remediation and 540 patients in a control condition. We found a small effect on DS (g = 0.28, 95% CI 0.09–0.46, I 2 40%), a medium effect on CF (g = 0.60, 95% CI 0.37–0.83, I 2 44%) and a small effect on DF (g = 0.22, 95% CI 0.06–0.39, I 2 3%). There were no significant effects at follow-up. Confounding bias analyses indicated possible overestimation of the DS and DF effects in the original studies. Conclusions: Cognitive remediation in depression improves CF in the short term. The effects on DS and DF may have been overestimated. Baseline depressive symptom severity should be considered when administering cognitive remediation. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 161171594
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effectiveness of cognitive remediation in depression: a meta-analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Legemaat%2C+Amanda+M%2E%22">Legemaat, Amanda M.</searchLink><br /><searchLink fieldCode="AR" term="%22Semkovska%2C+Maria%22">Semkovska, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Brouwer%2C+Marlies%22">Brouwer, Marlies</searchLink><br /><searchLink fieldCode="AR" term="%22Geurtsen%2C+Gert+J%2E%22">Geurtsen, Gert J.</searchLink><br /><searchLink fieldCode="AR" term="%22Burger%2C+Huibert%22">Burger, Huibert</searchLink><br /><searchLink fieldCode="AR" term="%22Denys%2C+Damiaan%22">Denys, Damiaan</searchLink><br /><searchLink fieldCode="AR" term="%22Bockting%2C+Claudi+L%2E%22">Bockting, Claudi L.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Dec2022, Vol. 52 Issue 16, p4146-4161. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Prevention+of+psychological+stress%22">Prevention of psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse+prevention%22">Disease relapse prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+information+storage+%26+retrieval+systems%22">Psychology information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+databases%22">Medical databases</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+information+storage+%26+retrieval+systems%22">Medical information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+assessment%22">Functional assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+remediation%22">Cognitive remediation</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Preliminary evidence suggests beneficial effects of cognitive remediation in depression. An update of the current evidence is needed. The aim was to systematically assess the effectiveness of cognitive remediation in depression on three outcomes. Methods: The meta-analysis was pre-registered on PROSPERO (CRD42019124316). PubMed, PsycINFO, Embase and Cochrane Library were searched on 2 February 2019 and 8 November 2020 for peer-reviewed published articles. We included randomized and non-randomized clinical trials comparing cognitive remediation to control conditions in adults with primary depression. Random-effects models were used to calculate Hedges' g , and moderators were assessed using mixed-effects subgroup analyses and meta-regression. Main outcome categories were post-treatment depressive symptomatology (DS), cognitive functioning (CF) and daily functioning (DF). Results: We identified 5221 records and included 21 studies reporting on 24 comparisons, with 438 depressed patients receiving cognitive remediation and 540 patients in a control condition. We found a small effect on DS (g = 0.28, 95% CI 0.09–0.46, I 2 40%), a medium effect on CF (g = 0.60, 95% CI 0.37–0.83, I 2 44%) and a small effect on DF (g = 0.22, 95% CI 0.06–0.39, I 2 3%). There were no significant effects at follow-up. Confounding bias analyses indicated possible overestimation of the DS and DF effects in the original studies. Conclusions: Cognitive remediation in depression improves CF in the short term. The effects on DS and DF may have been overestimated. Baseline depressive symptom severity should be considered when administering cognitive remediation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=161171594
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291721001100
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 4146
    Subjects:
      – SubjectFull: Prevention of psychological stress
        Type: general
      – SubjectFull: Disease relapse prevention
        Type: general
      – SubjectFull: Online information services
        Type: general
      – SubjectFull: Psychology information storage & retrieval systems
        Type: general
      – SubjectFull: Medical databases
        Type: general
      – SubjectFull: Meta-analysis
        Type: general
      – SubjectFull: Medical information storage & retrieval systems
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: Mild cognitive impairment
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Functional assessment
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Cognitive remediation
        Type: general
      – SubjectFull: MEDLINE
        Type: general
    Titles:
      – TitleFull: Effectiveness of cognitive remediation in depression: a meta-analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Legemaat, Amanda M.
      – PersonEntity:
          Name:
            NameFull: Semkovska, Maria
      – PersonEntity:
          Name:
            NameFull: Brouwer, Marlies
      – PersonEntity:
          Name:
            NameFull: Geurtsen, Gert J.
      – PersonEntity:
          Name:
            NameFull: Burger, Huibert
      – PersonEntity:
          Name:
            NameFull: Denys, Damiaan
      – PersonEntity:
          Name:
            NameFull: Bockting, Claudi L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 00332917
          Numbering:
            – Type: volume
              Value: 52
            – Type: issue
              Value: 16
          Titles:
            – TitleFull: Psychological Medicine
              Type: main
ResultId 1