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A multivariate genetic analysis of anxiety sensitivity, environmental sensitivity and reported life events in adolescents.

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Title: A multivariate genetic analysis of anxiety sensitivity, environmental sensitivity and reported life events in adolescents.
Authors: Peel, Alicia J., Oginni, Olakunle, Assary, Elham, Krebs, Georgina, Lockhart, Celestine, McGregor, Thomas, Palaiologou, Elisavet, Ronald, Angelica, Danese, Andrea, Eley, Thalia C.
Source: Journal of Child Psychology & Psychiatry. Feb2023, Vol. 64 Issue 2, p289-298. 10p. 3 Diagrams, 2 Charts.
Subjects: Self-evaluation, Multivariate analysis, Genetic testing, Environmentally induced diseases, Descriptive statistics, Research funding, Anxiety, Adolescence
Abstract: Background: Despite being considered a measure of environmental risk, reported life events are partly heritable. One mechanism that may contribute to this heritability is genetic influences on sensitivity, relating to how individuals process and interpret internal and external signals. The aim of this study was to explore the genetic and environmental overlap between self‐reported life events and measures of sensitivity. Methods: At age 17, 2,939 individuals from the Twins Early Development Study (TEDS) completed measures of anxiety sensitivity (Children's Anxiety Sensitivity Index), environmental sensitivity (Highly Sensitive Child Scale) and reported their experience of 20 recent life events. Using multivariate Cholesky decomposition models, we investigated the shared genetic and environmental influences on the associations between these measures of sensitivity and the number of reported life events, as well as both negative and positive ratings of life events. Results: The majority of the associations between anxiety sensitivity, environmental sensitivity and reported life events were explained by shared genetic influences (60%–75%), with the remainder explained by nonshared environmental influences (25%–40%). Environmental sensitivity showed comparable genetic correlations with both negative and positive ratings of life events (rA =.21 and.15), anxiety sensitivity only showed a significant genetic correlation with negative ratings of life events (rA =.33). Approximately 10% of the genetic influences on reported life events were accounted for by influences shared with anxiety sensitivity and environmental sensitivity. Conclusion: Differences in how individuals process the contextual aspects of the environment or interpret their own physical and emotional response to environmental stimuli may be one mechanism through which genetic liability influences the subjective experience of life events. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: A multivariate genetic analysis of anxiety sensitivity, environmental sensitivity and reported life events in adolescents.
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  Data: <searchLink fieldCode="AR" term="%22Peel%2C+Alicia+J%2E%22">Peel, Alicia J.</searchLink><br /><searchLink fieldCode="AR" term="%22Oginni%2C+Olakunle%22">Oginni, Olakunle</searchLink><br /><searchLink fieldCode="AR" term="%22Assary%2C+Elham%22">Assary, Elham</searchLink><br /><searchLink fieldCode="AR" term="%22Krebs%2C+Georgina%22">Krebs, Georgina</searchLink><br /><searchLink fieldCode="AR" term="%22Lockhart%2C+Celestine%22">Lockhart, Celestine</searchLink><br /><searchLink fieldCode="AR" term="%22McGregor%2C+Thomas%22">McGregor, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Palaiologou%2C+Elisavet%22">Palaiologou, Elisavet</searchLink><br /><searchLink fieldCode="AR" term="%22Ronald%2C+Angelica%22">Ronald, Angelica</searchLink><br /><searchLink fieldCode="AR" term="%22Danese%2C+Andrea%22">Danese, Andrea</searchLink><br /><searchLink fieldCode="AR" term="%22Eley%2C+Thalia+C%2E%22">Eley, Thalia C.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Feb2023, Vol. 64 Issue 2, p289-298. 10p. 3 Diagrams, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Self-evaluation%22">Self-evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+testing%22">Genetic testing</searchLink><br /><searchLink fieldCode="DE" term="%22Environmentally+induced+diseases%22">Environmentally induced diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
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  Data: Background: Despite being considered a measure of environmental risk, reported life events are partly heritable. One mechanism that may contribute to this heritability is genetic influences on sensitivity, relating to how individuals process and interpret internal and external signals. The aim of this study was to explore the genetic and environmental overlap between self‐reported life events and measures of sensitivity. Methods: At age 17, 2,939 individuals from the Twins Early Development Study (TEDS) completed measures of anxiety sensitivity (Children's Anxiety Sensitivity Index), environmental sensitivity (Highly Sensitive Child Scale) and reported their experience of 20 recent life events. Using multivariate Cholesky decomposition models, we investigated the shared genetic and environmental influences on the associations between these measures of sensitivity and the number of reported life events, as well as both negative and positive ratings of life events. Results: The majority of the associations between anxiety sensitivity, environmental sensitivity and reported life events were explained by shared genetic influences (60%–75%), with the remainder explained by nonshared environmental influences (25%–40%). Environmental sensitivity showed comparable genetic correlations with both negative and positive ratings of life events (rA =.21 and.15), anxiety sensitivity only showed a significant genetic correlation with negative ratings of life events (rA =.33). Approximately 10% of the genetic influences on reported life events were accounted for by influences shared with anxiety sensitivity and environmental sensitivity. Conclusion: Differences in how individuals process the contextual aspects of the environment or interpret their own physical and emotional response to environmental stimuli may be one mechanism through which genetic liability influences the subjective experience of life events. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/jcpp.13725
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        Text: English
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      – SubjectFull: Anxiety
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      – SubjectFull: Adolescence
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              Text: Feb2023
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