Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer's disease compared to neurological disease controls: a retrospective study on 276 patients.
Saved in:
| Title: | Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer's disease compared to neurological disease controls: a retrospective study on 276 patients. |
|---|---|
| Authors: | Giacopuzzi Grigoli, Eleonora (AUTHOR), Solca, Federica (AUTHOR), Milone, Ilaria (AUTHOR), Aiello, Edoardo Nicolò (AUTHOR), Dubini, Antonella (AUTHOR), Ratti, Antonia (AUTHOR), Torresani, Erminio (AUTHOR), Poletti, Barbara (AUTHOR), Ticozzi, Nicola (AUTHOR), Ciusani, Emilio (AUTHOR), Silani, Vincenzo (AUTHOR), Verde, Federico (AUTHOR) |
| Source: | Neurological Sciences. Feb2023, Vol. 44 Issue 2, p709-713. 5p. 1 Chart, 1 Graph. |
| Subjects: | Alzheimer's disease, Cerebrospinal fluid, Serum albumin, Neurological disorders, Preventive medicine |
| Abstract: | Background : The cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) is a marker of the blood-CSF barrier (BCSFB) and possibly of the blood–brain barrier (BBB). The latter is known to be altered in Alzheimer's disease (AD) based on neuropathological and neuroimaging studies. Following investigations performed on clinically diagnosed cohorts, we aimed at comparing Q-Alb in cognitively impaired patients with neurochemical demonstration of AD pathophysiology and neurological disease controls (NDCs). Methods: We evaluated N = 144 AD patients (MCI, N = 43; AD dementia — ADD, N = 101) and N = 132 NDCs. AD patients were all A + according to the A/T/N framework and were neurochemically classified based on T and N parameters. Results: Q-Alb did not significantly differ between AD patients and NDCs. Moreover, it was not associated with disease stage (MCI vs. ADD), MMSE score, or CSF AD biomarkers. Discussion: Our study indicates that BCSFB dysfunction is not a specific feature of AD. When interpreting Q-Alb as a marker of the BBB, the lack of difference from NDCs might be due to BBB dysfunction widely occurring in other neurological, non-degenerative, conditions or — more probably — to low sensitivity of this biochemical parameter towards subtle BBB alterations causing leakage of molecules smaller than albumin. Furthermore, Q-Alb is not associated with the degree of global cognitive deterioration in AD, nor with CSF AD neurochemical biomarkers. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 161327413 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer's disease compared to neurological disease controls: a retrospective study on 276 patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Giacopuzzi+Grigoli%2C+Eleonora%22">Giacopuzzi Grigoli, Eleonora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solca%2C+Federica%22">Solca, Federica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Milone%2C+Ilaria%22">Milone, Ilaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aiello%2C+Edoardo+Nicolò%22">Aiello, Edoardo Nicolò</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dubini%2C+Antonella%22">Dubini, Antonella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ratti%2C+Antonia%22">Ratti, Antonia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torresani%2C+Erminio%22">Torresani, Erminio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poletti%2C+Barbara%22">Poletti, Barbara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ticozzi%2C+Nicola%22">Ticozzi, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ciusani%2C+Emilio%22">Ciusani, Emilio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silani%2C+Vincenzo%22">Silani, Vincenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verde%2C+Federico%22">Verde, Federico</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Feb2023, Vol. 44 Issue 2, p709-713. 5p. 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrospinal+fluid%22">Cerebrospinal fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Serum+albumin%22">Serum albumin</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Preventive+medicine%22">Preventive medicine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background : The cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) is a marker of the blood-CSF barrier (BCSFB) and possibly of the blood–brain barrier (BBB). The latter is known to be altered in Alzheimer's disease (AD) based on neuropathological and neuroimaging studies. Following investigations performed on clinically diagnosed cohorts, we aimed at comparing Q-Alb in cognitively impaired patients with neurochemical demonstration of AD pathophysiology and neurological disease controls (NDCs). Methods: We evaluated N = 144 AD patients (MCI, N = 43; AD dementia — ADD, N = 101) and N = 132 NDCs. AD patients were all A + according to the A/T/N framework and were neurochemically classified based on T and N parameters. Results: Q-Alb did not significantly differ between AD patients and NDCs. Moreover, it was not associated with disease stage (MCI vs. ADD), MMSE score, or CSF AD biomarkers. Discussion: Our study indicates that BCSFB dysfunction is not a specific feature of AD. When interpreting Q-Alb as a marker of the BBB, the lack of difference from NDCs might be due to BBB dysfunction widely occurring in other neurological, non-degenerative, conditions or — more probably — to low sensitivity of this biochemical parameter towards subtle BBB alterations causing leakage of molecules smaller than albumin. Furthermore, Q-Alb is not associated with the degree of global cognitive deterioration in AD, nor with CSF AD neurochemical biomarkers. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=161327413 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-022-06530-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 709 Subjects: – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Cerebrospinal fluid Type: general – SubjectFull: Serum albumin Type: general – SubjectFull: Neurological disorders Type: general – SubjectFull: Preventive medicine Type: general Titles: – TitleFull: Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer's disease compared to neurological disease controls: a retrospective study on 276 patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Giacopuzzi Grigoli, Eleonora – PersonEntity: Name: NameFull: Solca, Federica – PersonEntity: Name: NameFull: Milone, Ilaria – PersonEntity: Name: NameFull: Aiello, Edoardo Nicolò – PersonEntity: Name: NameFull: Dubini, Antonella – PersonEntity: Name: NameFull: Ratti, Antonia – PersonEntity: Name: NameFull: Torresani, Erminio – PersonEntity: Name: NameFull: Poletti, Barbara – PersonEntity: Name: NameFull: Ticozzi, Nicola – PersonEntity: Name: NameFull: Ciusani, Emilio – PersonEntity: Name: NameFull: Silani, Vincenzo – PersonEntity: Name: NameFull: Verde, Federico IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 44 – Type: issue Value: 2 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
