View in EDS HTML Full Text PDF Full Text

Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study.

Saved in:
Bibliographic Details
Title: Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study.
Authors: Cerulli Irelli, Emanuele (AUTHOR), Cocchi, Enrico (AUTHOR), Ramantani, Georgia (AUTHOR), Riva, Antonella (AUTHOR), Caraballo, Roberto Horacio (AUTHOR), Morano, Alessandra (AUTHOR), Giuliano, Loretta (AUTHOR), Yilmaz, Tülay (AUTHOR), Panagiotakaki, Eleni (AUTHOR), Operto, Francesca F. (AUTHOR), Giraldez, Beatriz Gonzalez (AUTHOR), Balestrini, Simona (AUTHOR), Silvennoinen, Katri (AUTHOR), Casciato, Sara (AUTHOR), Comajuan, Marion (AUTHOR), Fortunato, Francesco (AUTHOR), Giallonardo, Anna Teresa (AUTHOR), Gamirova, Rimma (AUTHOR), Coppola, Antonietta (AUTHOR), Di Gennaro, Giancarlo (AUTHOR)
Source: Epilepsia (Series 4). Jan2023, Vol. 64 Issue 1, p196-207. 12p.
Subjects: Epilepsy, Probability density function, Eyelids, Seizures (Medicine), Migraine aura, Age of onset
Abstract: Objective: Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable neuropsychiatric outcome. However, much work is still needed to better delineate this epilepsy syndrome. Methods: In this multicenter retrospective cohort study, we included 267 EEM patients from nine countries. Data on electroclinical and demographic features, intellectual functioning, migraine with or without aura, family history of epilepsy, and epilepsy syndromes in relatives were collected in each patient. The impact of age at epilepsy onset (AEO) on EEM clinical features was investigated, along with the distinctive clinical characteristics of patients showing sporadic myoclonia involving body regions other than eyelids (body‐MYO). Results: Kernel density estimation revealed a trimodal distribution of AEO, and Fisher–Jenks optimization disclosed three EEM subgroups: early onset (EO‐EEM), intermediate onset (IO‐EEM), and late onset (LO‐EEM). EO‐EEM was associated with the highest rate of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities and with the lowest rate of family history of epilepsy. LO‐EEM was associated with the highest proportion of body‐MYO and generalized tonic–clonic seizures (GTCS), whereas IO‐EEM had the lowest observed rate of additional findings. A family history of EEM was significantly more frequent in IO‐EEM and LO‐EEM compared with EO‐EEM. In the subset of patients with body‐MYO (58/267), we observed a significantly higher rate of migraine and GTCS but no relevant differences in other electroclinical features and seizure outcome. Significance: Based on AEO, we identified consistent EEM subtypes characterized by distinct electroclinical and familial features. Our observations shed new light on the spectrum of clinical features of this generalized epilepsy syndrome and may help clinicians toward a more accurate classification and prognostic profiling of EEM patients. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 161365661
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Cerulli+Irelli%2C+Emanuele%22">Cerulli Irelli, Emanuele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cocchi%2C+Enrico%22">Cocchi, Enrico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramantani%2C+Georgia%22">Ramantani, Georgia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riva%2C+Antonella%22">Riva, Antonella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caraballo%2C+Roberto+Horacio%22">Caraballo, Roberto Horacio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morano%2C+Alessandra%22">Morano, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giuliano%2C+Loretta%22">Giuliano, Loretta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yilmaz%2C+Tülay%22">Yilmaz, Tülay</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Panagiotakaki%2C+Eleni%22">Panagiotakaki, Eleni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Operto%2C+Francesca+F%2E%22">Operto, Francesca F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giraldez%2C+Beatriz+Gonzalez%22">Giraldez, Beatriz Gonzalez</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balestrini%2C+Simona%22">Balestrini, Simona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silvennoinen%2C+Katri%22">Silvennoinen, Katri</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Casciato%2C+Sara%22">Casciato, Sara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Comajuan%2C+Marion%22">Comajuan, Marion</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fortunato%2C+Francesco%22">Fortunato, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giallonardo%2C+Anna+Teresa%22">Giallonardo, Anna Teresa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gamirova%2C+Rimma%22">Gamirova, Rimma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coppola%2C+Antonietta%22">Coppola, Antonietta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Di+Gennaro%2C+Giancarlo%22">Di Gennaro, Giancarlo</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jan2023, Vol. 64 Issue 1, p196-207. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+density+function%22">Probability density function</searchLink><br /><searchLink fieldCode="DE" term="%22Eyelids%22">Eyelids</searchLink><br /><searchLink fieldCode="DE" term="%22Seizures+%28Medicine%29%22">Seizures (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine+aura%22">Migraine aura</searchLink><br /><searchLink fieldCode="DE" term="%22Age+of+onset%22">Age of onset</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Epilepsy with eyelid myoclonia (EEM) has been associated with marked clinical heterogeneity. Early epilepsy onset has been recently linked to lower chances of achieving sustained remission and to a less favorable neuropsychiatric outcome. However, much work is still needed to better delineate this epilepsy syndrome. Methods: In this multicenter retrospective cohort study, we included 267 EEM patients from nine countries. Data on electroclinical and demographic features, intellectual functioning, migraine with or without aura, family history of epilepsy, and epilepsy syndromes in relatives were collected in each patient. The impact of age at epilepsy onset (AEO) on EEM clinical features was investigated, along with the distinctive clinical characteristics of patients showing sporadic myoclonia involving body regions other than eyelids (body‐MYO). Results: Kernel density estimation revealed a trimodal distribution of AEO, and Fisher–Jenks optimization disclosed three EEM subgroups: early onset (EO‐EEM), intermediate onset (IO‐EEM), and late onset (LO‐EEM). EO‐EEM was associated with the highest rate of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities and with the lowest rate of family history of epilepsy. LO‐EEM was associated with the highest proportion of body‐MYO and generalized tonic–clonic seizures (GTCS), whereas IO‐EEM had the lowest observed rate of additional findings. A family history of EEM was significantly more frequent in IO‐EEM and LO‐EEM compared with EO‐EEM. In the subset of patients with body‐MYO (58/267), we observed a significantly higher rate of migraine and GTCS but no relevant differences in other electroclinical features and seizure outcome. Significance: Based on AEO, we identified consistent EEM subtypes characterized by distinct electroclinical and familial features. Our observations shed new light on the spectrum of clinical features of this generalized epilepsy syndrome and may help clinicians toward a more accurate classification and prognostic profiling of EEM patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=161365661
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/epi.17450
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 196
    Subjects:
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Probability density function
        Type: general
      – SubjectFull: Eyelids
        Type: general
      – SubjectFull: Seizures (Medicine)
        Type: general
      – SubjectFull: Migraine aura
        Type: general
      – SubjectFull: Age of onset
        Type: general
    Titles:
      – TitleFull: Spectrum of epilepsy with eyelid myoclonia: Delineation of disease subtypes from a large multicenter study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Cerulli Irelli, Emanuele
      – PersonEntity:
          Name:
            NameFull: Cocchi, Enrico
      – PersonEntity:
          Name:
            NameFull: Ramantani, Georgia
      – PersonEntity:
          Name:
            NameFull: Riva, Antonella
      – PersonEntity:
          Name:
            NameFull: Caraballo, Roberto Horacio
      – PersonEntity:
          Name:
            NameFull: Morano, Alessandra
      – PersonEntity:
          Name:
            NameFull: Giuliano, Loretta
      – PersonEntity:
          Name:
            NameFull: Yilmaz, Tülay
      – PersonEntity:
          Name:
            NameFull: Panagiotakaki, Eleni
      – PersonEntity:
          Name:
            NameFull: Operto, Francesca F.
      – PersonEntity:
          Name:
            NameFull: Giraldez, Beatriz Gonzalez
      – PersonEntity:
          Name:
            NameFull: Balestrini, Simona
      – PersonEntity:
          Name:
            NameFull: Silvennoinen, Katri
      – PersonEntity:
          Name:
            NameFull: Casciato, Sara
      – PersonEntity:
          Name:
            NameFull: Comajuan, Marion
      – PersonEntity:
          Name:
            NameFull: Fortunato, Francesco
      – PersonEntity:
          Name:
            NameFull: Giallonardo, Anna Teresa
      – PersonEntity:
          Name:
            NameFull: Gamirova, Rimma
      – PersonEntity:
          Name:
            NameFull: Coppola, Antonietta
      – PersonEntity:
          Name:
            NameFull: Di Gennaro, Giancarlo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 00139580
          Numbering:
            – Type: volume
              Value: 64
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Epilepsia (Series 4)
              Type: main
ResultId 1