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The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual‐participant data from 15 international studies.

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Title: The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual‐participant data from 15 international studies.
Authors: Mewton, Louise, Visontay, Rachel, Hoy, Nicholas, Lipnicki, Darren M., Sunderland, Matthew, Lipton, Richard B., Guerchet, Maëlenn, Ritchie, Karen, Najar, Jenna, Scarmeas, Nikolaos, Kim, Ki‐Woong, Riedel Heller, Steffi, van Boxtel, Martin, Jacobsen, Erin, Brodaty, Henry, Anstey, Kaarin J., Haan, Mary, Scazufca, Marcia, Lobo, Elena, Sachdev, Perminder S.
Source: Addiction. Mar2023, Vol. 118 Issue 3, p412-424. 13p. 3 Charts, 2 Graphs.
Subjects: Dementia risk factors, Complications of alcoholism, Middle-income countries, Confidence intervals, Age distribution, Population geography, Disease incidence, Risk assessment, Sex distribution, Comparative studies, Alcohol drinking, Attribution (Social psychology), Low-income countries, Dementia, Disease prevalence, Descriptive statistics, Dose-response relationship in biochemistry, Middle age
Abstract: Aim: To synthesize international findings on the alcohol–dementia relationship, including representation from low‐ and middle‐income countries. Methods: Individual participant data meta‐analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. Additional analyses assessed the alcohol–dementia relationship in the sample stratified by sex and by continent. Participants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow‐up dementia assessment. The main outcome measure was all‐cause dementia as determined by clinical interview. Results: At baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60–102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. During 151 636 person‐years of follow‐up, there were 2124 incident cases of dementia (14.0 per 1000 person‐years). When compared with abstainers, the risk for dementia was lower in occasional [hazard ratio (HR) = 0.78; 95% confidence interval (CI) = 0.68–0.89], light–moderate (HR = 0.78; 95% CI = 0.70–0.87) and moderate–heavy drinkers (HR = 0.62; 95% CI = 0.51–0.77). There was no evidence of differences between life‐time abstainers and former drinkers in terms of dementia risk (HR = 0.98; 95% CI = 0.81–1.18). In dose–response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lif‐time abstaining. Among current drinkers, there was no consistent evidence for differences in terms of dementia risk. Results were similar when the sample was stratified by sex. When analysed at the continent level, there was considerable heterogeneity in the alcohol–dementia relationship. Conclusions: Abstinence from alcohol appears to be associated with an increased risk for all‐cause dementia. Among current drinkers, there appears to be no consistent evidence to suggest that the amount of alcohol consumed in later life is associated with dementia risk. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The relationship between alcohol use and dementia in adults aged more than 60 years: a combined analysis of prospective, individual‐participant data from 15 international studies.
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  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Mar2023, Vol. 118 Issue 3, p412-424. 13p. 3 Charts, 2 Graphs.
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– Name: Abstract
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  Data: Aim: To synthesize international findings on the alcohol–dementia relationship, including representation from low‐ and middle‐income countries. Methods: Individual participant data meta‐analysis of 15 prospective epidemiological cohort studies from countries situated in six continents. Cox regression investigated the dementia risk associated with alcohol use in older adults aged over 60 years. Additional analyses assessed the alcohol–dementia relationship in the sample stratified by sex and by continent. Participants included 24 478 community dwelling individuals without a history of dementia at baseline and at least one follow‐up dementia assessment. The main outcome measure was all‐cause dementia as determined by clinical interview. Results: At baseline, the mean age across studies was 71.8 (standard deviation = 7.5, range = 60–102 years), 14 260 (58.3%) were female and 13 269 (54.2%) were current drinkers. During 151 636 person‐years of follow‐up, there were 2124 incident cases of dementia (14.0 per 1000 person‐years). When compared with abstainers, the risk for dementia was lower in occasional [hazard ratio (HR) = 0.78; 95% confidence interval (CI) = 0.68–0.89], light–moderate (HR = 0.78; 95% CI = 0.70–0.87) and moderate–heavy drinkers (HR = 0.62; 95% CI = 0.51–0.77). There was no evidence of differences between life‐time abstainers and former drinkers in terms of dementia risk (HR = 0.98; 95% CI = 0.81–1.18). In dose–response analyses, moderate drinking up to 40 g/day was associated with a lower risk of dementia when compared with lif‐time abstaining. Among current drinkers, there was no consistent evidence for differences in terms of dementia risk. Results were similar when the sample was stratified by sex. When analysed at the continent level, there was considerable heterogeneity in the alcohol–dementia relationship. Conclusions: Abstinence from alcohol appears to be associated with an increased risk for all‐cause dementia. Among current drinkers, there appears to be no consistent evidence to suggest that the amount of alcohol consumed in later life is associated with dementia risk. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/add.16035
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      – SubjectFull: Dementia risk factors
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      – SubjectFull: Complications of alcoholism
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