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Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder.

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Title: Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder.
Authors: Propper, L., Sandstrom, A., Rempel, S., Howes Vallis, E., Abidi, S., Bagnell, A., Lovas, D., Alda, M., Pavlova, B., Uher, R.
Source: Psychological Medicine. Jan2023, Vol. 53 Issue 2, p559-566. 8p.
Subjects: Diagnosis of autism, Diagnosis of learning disabilities, Confidence intervals, Attention-deficit hyperactivity disorder, Communicative disorders, Child psychopathology, Mental depression, Children of people with mental illness, Pathological psychology, Affective disorders, Research funding, Odds ratio, Bipolar disorder, Parents, Intellectual disabilities, Early diagnosis, Early medical intervention, Disease complications
Abstract: Background: Offspring of parents with major mood disorders (MDDs) are at increased risk for early psychopathology. We aim to compare the rates of neurodevelopmental disorders in offspring of parents with bipolar disorder, major depressive disorder, and controls. Method: We established a lifetime diagnosis of neurodevelopmental disorders [attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disabilities, specific learning disorders, and motor disorders] using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version in 400 participants (mean age 11.3 + s.d. 3.9 years), including 93 offspring of parents with bipolar disorder, 182 offspring of parents with major depressive disorder, and 125 control offspring of parents with no mood disorder. Results: Neurodevelopmental disorders were elevated in offspring of parents with bipolar disorder [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.23–4.47, p = 0.010] and major depressive disorder (OR 1.87, 95% CI 1.03–3.39, p = 0.035) compared to controls. This difference was driven by the rates of ADHD, which were highest among offspring of parents with bipolar disorder (30.1%), intermediate in offspring of parents with major depressive disorder (24.2%), and lowest in controls (14.4%). There were no significant differences in frequencies of other neurodevelopmental disorders between the three groups. Chronic course of mood disorder in parents was associated with higher rates of any neurodevelopmental disorder and higher rates of ADHD in offspring. Conclusions: Our findings suggest monitoring for ADHD and other neurodevelopmental disorders in offspring of parents with MDDs may be indicated to improve early diagnosis and treatment. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder.
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  Data: <searchLink fieldCode="AR" term="%22Propper%2C+L%2E%22">Propper, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Sandstrom%2C+A%2E%22">Sandstrom, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Rempel%2C+S%2E%22">Rempel, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes+Vallis%2C+E%2E%22">Howes Vallis, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Abidi%2C+S%2E%22">Abidi, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Bagnell%2C+A%2E%22">Bagnell, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lovas%2C+D%2E%22">Lovas, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Alda%2C+M%2E%22">Alda, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Pavlova%2C+B%2E%22">Pavlova, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Uher%2C+R%2E%22">Uher, R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jan2023, Vol. 53 Issue 2, p559-566. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+autism%22">Diagnosis of autism</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis+of+learning+disabilities%22">Diagnosis of learning disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Communicative+disorders%22">Communicative disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Child+psychopathology%22">Child psychopathology</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Children+of+people+with+mental+illness%22">Children of people with mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Parents%22">Parents</searchLink><br /><searchLink fieldCode="DE" term="%22Intellectual+disabilities%22">Intellectual disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Early+diagnosis%22">Early diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Early+medical+intervention%22">Early medical intervention</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Offspring of parents with major mood disorders (MDDs) are at increased risk for early psychopathology. We aim to compare the rates of neurodevelopmental disorders in offspring of parents with bipolar disorder, major depressive disorder, and controls. Method: We established a lifetime diagnosis of neurodevelopmental disorders [attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disabilities, specific learning disorders, and motor disorders] using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version in 400 participants (mean age 11.3 + s.d. 3.9 years), including 93 offspring of parents with bipolar disorder, 182 offspring of parents with major depressive disorder, and 125 control offspring of parents with no mood disorder. Results: Neurodevelopmental disorders were elevated in offspring of parents with bipolar disorder [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.23–4.47, p = 0.010] and major depressive disorder (OR 1.87, 95% CI 1.03–3.39, p = 0.035) compared to controls. This difference was driven by the rates of ADHD, which were highest among offspring of parents with bipolar disorder (30.1%), intermediate in offspring of parents with major depressive disorder (24.2%), and lowest in controls (14.4%). There were no significant differences in frequencies of other neurodevelopmental disorders between the three groups. Chronic course of mood disorder in parents was associated with higher rates of any neurodevelopmental disorder and higher rates of ADHD in offspring. Conclusions: Our findings suggest monitoring for ADHD and other neurodevelopmental disorders in offspring of parents with MDDs may be indicated to improve early diagnosis and treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291721001951
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      – Code: eng
        Text: English
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        StartPage: 559
    Subjects:
      – SubjectFull: Diagnosis of autism
        Type: general
      – SubjectFull: Diagnosis of learning disabilities
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Attention-deficit hyperactivity disorder
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      – SubjectFull: Communicative disorders
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      – SubjectFull: Child psychopathology
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      – SubjectFull: Mental depression
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      – SubjectFull: Children of people with mental illness
        Type: general
      – SubjectFull: Pathological psychology
        Type: general
      – SubjectFull: Affective disorders
        Type: general
      – SubjectFull: Research funding
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      – SubjectFull: Odds ratio
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      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Parents
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      – SubjectFull: Intellectual disabilities
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      – SubjectFull: Early diagnosis
        Type: general
      – SubjectFull: Early medical intervention
        Type: general
      – SubjectFull: Disease complications
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    Titles:
      – TitleFull: Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder.
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              Text: Jan2023
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