Risk of autism spectrum disorder in offspring with parental schizophrenia: a systematic review and meta-analysis.
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| Title: | Risk of autism spectrum disorder in offspring with parental schizophrenia: a systematic review and meta-analysis. |
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| Authors: | Shayestehfar, Monir (AUTHOR), Nakhostin-Ansari, Amin (AUTHOR), Memari, Amirhossein (AUTHOR), Hosseini Asl, Seyed Hossein (AUTHOR), Faghihi, Faezeh (AUTHOR) |
| Source: | Nordic Journal of Psychiatry. Feb2023, Vol. 77 Issue 2, p127-136. 10p. |
| Subjects: | Autism spectrum disorders, Schizophrenia, Publication bias |
| Abstract: | The effect of parental schizophrenia on the risk of Autism Spectrum Disorders (ASD) in offspring has been evaluated in previous studies. However, to our knowledge, no systematic review and meta-analysis have assessed this association. In this study, we aimed to evaluate the risk of ASD in offspring with parental schizophrenia. The electronic databases EMBASE, PubMed, and Scopus were systematically searched. We administered the Newcastle Ottawa quality assessment scale (NOS) to assess the quality of all selected studies. Combined effect values, as well as their 95% confidence intervals (CI), were calculated. We evaluated heterogeneity using Q and I2 statistics. The publication bias was evaluated by funnel plot and Egger's regression test. In addition, a leave-one-out sensitivity analysis was performed to assess the robustness of the finding. A total of 12 observational studies (10 cohorts and two case-control) were included. Our study found a high risk of ASD in offspring exposed to parental schizophrenia [RR = 2.38 (CI%95 2.0–2.83)]. Subgroup and sensitivity analysis confirmed the robustness of our main analysis. The risk of ASD is considerably higher in offspring with parental schizophrenia. Our findings may suggest a shared pathologic pathway between schizophrenia and ASD. [ABSTRACT FROM AUTHOR] |
| Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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