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Neuromedin-U is regulated by the circadian clock in the SCN of the mouse.

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Title: Neuromedin-U is regulated by the circadian clock in the SCN of the mouse.
Authors: Graham, E. Scott (AUTHOR), Littlewood, Pauline (AUTHOR), Turnbull, Yvonne (AUTHOR), Mercer, Julian G. (AUTHOR), Morgan, Peter J. (AUTHOR), Barrett, Perry (AUTHOR)
Source: European Journal of Neuroscience. Feb2005, Vol. 21 Issue 3, p814-819. 6p.
Subjects: Gene expression, Biological rhythms, Hypothalamo-hypophyseal system, Human behavior, Brain research, Psychological research
Abstract: Neuromedin-U (NMU) has been reported to drive several physiological or behavioural responses following i.c.v. injection of the peptide into the third ventricle of rodent brains. Many of these responses are mediated through a change in corticotrophin-releasing factor (CRF) output from the paraventricular nucleus (PVN). A number of the physiological or behavioural responses are regulated in a circadian manner, e.g. feeding. We have previously reported NMU gene expression in the suprachiasmatci nucleus (SCN) and NMU-2 receptor expression in the PVN, dorsal medial hypothalamus (DMH) and other regions of the mouse brain. We therefore hypothesized that NMU would be regulated by the circadian clock and may consequently drive a circadian rhythm of CRF expression in the PVN. Here we report that NMU is regulated in a circadian manner with peak expression during the light phase of a light–dark cycle. In C3H mice held in constant darkness, the NMU rhythm free runs with a period predicted by the free running period of locomotor activity in this mouse. The NMU mRNA transcript colocalizes with cells expressing AVP in the SCN and shows a coincident rhythm of expression with AVP. On the other hand, CRF did not express a circadian rhythm of expression in a light–dark cycle, although a rhythm was evident in constant darkness with a peak of expression prior to the rise of NMU in the same conditions. This would suggest that the circadian rhythm in NMU expression in the SCN does not drive a circadian rhythm in CRF in the PVN to be translated into physiological and behavioural responses mediated by NMU. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Neuromedin-U is regulated by the circadian clock in the SCN of the mouse.
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  Data: <searchLink fieldCode="AR" term="%22Graham%2C+E%2E+Scott%22">Graham, E. Scott</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Littlewood%2C+Pauline%22">Littlewood, Pauline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Turnbull%2C+Yvonne%22">Turnbull, Yvonne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mercer%2C+Julian+G%2E%22">Mercer, Julian G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morgan%2C+Peter+J%2E%22">Morgan, Peter J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barrett%2C+Perry%22">Barrett, Perry</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Feb2005, Vol. 21 Issue 3, p814-819. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+rhythms%22">Biological rhythms</searchLink><br /><searchLink fieldCode="DE" term="%22Hypothalamo-hypophyseal+system%22">Hypothalamo-hypophyseal system</searchLink><br /><searchLink fieldCode="DE" term="%22Human+behavior%22">Human behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+research%22">Brain research</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+research%22">Psychological research</searchLink>
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  Data: Neuromedin-U (NMU) has been reported to drive several physiological or behavioural responses following i.c.v. injection of the peptide into the third ventricle of rodent brains. Many of these responses are mediated through a change in corticotrophin-releasing factor (CRF) output from the paraventricular nucleus (PVN). A number of the physiological or behavioural responses are regulated in a circadian manner, e.g. feeding. We have previously reported NMU gene expression in the suprachiasmatci nucleus (SCN) and NMU-2 receptor expression in the PVN, dorsal medial hypothalamus (DMH) and other regions of the mouse brain. We therefore hypothesized that NMU would be regulated by the circadian clock and may consequently drive a circadian rhythm of CRF expression in the PVN. Here we report that NMU is regulated in a circadian manner with peak expression during the light phase of a light–dark cycle. In C3H mice held in constant darkness, the NMU rhythm free runs with a period predicted by the free running period of locomotor activity in this mouse. The NMU mRNA transcript colocalizes with cells expressing AVP in the SCN and shows a coincident rhythm of expression with AVP. On the other hand, CRF did not express a circadian rhythm of expression in a light–dark cycle, although a rhythm was evident in constant darkness with a peak of expression prior to the rise of NMU in the same conditions. This would suggest that the circadian rhythm in NMU expression in the SCN does not drive a circadian rhythm in CRF in the PVN to be translated into physiological and behavioural responses mediated by NMU. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Feb2005
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