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Swelling of Multilayered Calcium Alginate Microspheres for Drug-Loaded Dressing Induced Rapid Lidocaine Release for Better Pain Control.

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Title: Swelling of Multilayered Calcium Alginate Microspheres for Drug-Loaded Dressing Induced Rapid Lidocaine Release for Better Pain Control.
Authors: Ma, Rong-Rong (AUTHOR), Xu, Hui-Xian (AUTHOR), Ni, Li (AUTHOR), Xiong, Jia-Min (AUTHOR), Chen, Yi-Lin (AUTHOR), He, Jia-Yuan (AUTHOR), Li, Qin (AUTHOR), Yang, Li-Li (AUTHOR), Zhou, Lian-Di (AUTHOR), Zhang, Qi-Hui (AUTHOR), Luo, Ling (AUTHOR)
Source: American Journal of Chinese Medicine. 2022, Vol. 50 Issue 8, p2085-2102. 18p.
Subjects: Therapeutic use of proteins, Polysaccharides, Lidocaine, Drug delivery systems, In vitro studies, Pain, Animal experimentation, Permeability, Blood coagulation, Rats, Alginates, Adsorption (Chemistry), Calcium, Infrared spectroscopy, Surgical dressings, Bandages & bandaging, Nanoparticles
Abstract: The development of effective drug-loaded dressings has been considered a hot research topic for biomedical therapeutics, including the use of botanical compounds. For wound healing, adequate dressings can provide a good microenvironment for drug release, such as lidocaine. Biological macromolecular materials such as alginate show excellent properties in wound management. This study involves the preparation and evaluation of biocompatible multilayered-structure microspheres composed of chitosan, porous gelatin, and calcium alginate microspheres. The multilayered structure microspheres were named chitosan@ porous gelatin@ calcium alginate microspheres (CPAMs) and the drugs were rapidly released by the volume expansion of the calcium alginate microspheres. The in vitro release curve revealed that the peak release of lidocaine from CPAMs was reached within 18 min. After 21 min, the remaining lidocaine was then slowly released, and the active drug release was converted to a passive drug release phase. The initial release effect of lidocaine was much better than that reported in the published studies. Additionally, blood coagulation experiments showed that CPAMs coagulated blood in 60 s, and the blood liquidity of the CPAMs group was worse than that of the woundplast group. Therefore, the coagulation characteristics of CPAMs were superior to the commonly used woundplast containing lidocaine healing gel. These study outcomes indicated that the CPAMs acted as fast-release dressings for faster pain control and better coagulation properties. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Swelling of Multilayered Calcium Alginate Microspheres for Drug-Loaded Dressing Induced Rapid Lidocaine Release for Better Pain Control.
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  Data: <searchLink fieldCode="AR" term="%22Ma%2C+Rong-Rong%22">Ma, Rong-Rong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Hui-Xian%22">Xu, Hui-Xian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ni%2C+Li%22">Ni, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xiong%2C+Jia-Min%22">Xiong, Jia-Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Yi-Lin%22">Chen, Yi-Lin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+Jia-Yuan%22">He, Jia-Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Qin%22">Li, Qin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Li-Li%22">Yang, Li-Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Lian-Di%22">Zhou, Lian-Di</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Qi-Hui%22">Zhang, Qi-Hui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luo%2C+Ling%22">Luo, Ling</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Chinese+Medicine%22">American Journal of Chinese Medicine</searchLink>. 2022, Vol. 50 Issue 8, p2085-2102. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Therapeutic+use+of+proteins%22">Therapeutic use of proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Lidocaine%22">Lidocaine</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22In+vitro+studies%22">In vitro studies</searchLink><br /><searchLink fieldCode="DE" term="%22Pain%22">Pain</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Permeability%22">Permeability</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation%22">Blood coagulation</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Alginates%22">Alginates</searchLink><br /><searchLink fieldCode="DE" term="%22Adsorption+%28Chemistry%29%22">Adsorption (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium%22">Calcium</searchLink><br /><searchLink fieldCode="DE" term="%22Infrared+spectroscopy%22">Infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+dressings%22">Surgical dressings</searchLink><br /><searchLink fieldCode="DE" term="%22Bandages+%26+bandaging%22">Bandages & bandaging</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The development of effective drug-loaded dressings has been considered a hot research topic for biomedical therapeutics, including the use of botanical compounds. For wound healing, adequate dressings can provide a good microenvironment for drug release, such as lidocaine. Biological macromolecular materials such as alginate show excellent properties in wound management. This study involves the preparation and evaluation of biocompatible multilayered-structure microspheres composed of chitosan, porous gelatin, and calcium alginate microspheres. The multilayered structure microspheres were named chitosan@ porous gelatin@ calcium alginate microspheres (CPAMs) and the drugs were rapidly released by the volume expansion of the calcium alginate microspheres. The in vitro release curve revealed that the peak release of lidocaine from CPAMs was reached within 18 min. After 21 min, the remaining lidocaine was then slowly released, and the active drug release was converted to a passive drug release phase. The initial release effect of lidocaine was much better than that reported in the published studies. Additionally, blood coagulation experiments showed that CPAMs coagulated blood in 60 s, and the blood liquidity of the CPAMs group was worse than that of the woundplast group. Therefore, the coagulation characteristics of CPAMs were superior to the commonly used woundplast containing lidocaine healing gel. These study outcomes indicated that the CPAMs acted as fast-release dressings for faster pain control and better coagulation properties. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1142/S0192415X22500896
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 2085
    Subjects:
      – SubjectFull: Therapeutic use of proteins
        Type: general
      – SubjectFull: Polysaccharides
        Type: general
      – SubjectFull: Lidocaine
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: In vitro studies
        Type: general
      – SubjectFull: Pain
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Permeability
        Type: general
      – SubjectFull: Blood coagulation
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Alginates
        Type: general
      – SubjectFull: Adsorption (Chemistry)
        Type: general
      – SubjectFull: Calcium
        Type: general
      – SubjectFull: Infrared spectroscopy
        Type: general
      – SubjectFull: Surgical dressings
        Type: general
      – SubjectFull: Bandages & bandaging
        Type: general
      – SubjectFull: Nanoparticles
        Type: general
    Titles:
      – TitleFull: Swelling of Multilayered Calcium Alginate Microspheres for Drug-Loaded Dressing Induced Rapid Lidocaine Release for Better Pain Control.
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            NameFull: Ma, Rong-Rong
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            – D: 01
              M: 11
              Text: 2022
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              Y: 2022
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            – TitleFull: American Journal of Chinese Medicine
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