Can flat-detector CT after successful endovascular treatment predict long-term outcome in patients with large vessel occlusion? An Alberta Stroke Programme Early CT Score–based study.
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| Title: | Can flat-detector CT after successful endovascular treatment predict long-term outcome in patients with large vessel occlusion? An Alberta Stroke Programme Early CT Score–based study. |
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| Authors: | Knott, Michael (AUTHOR), Hoelter, Philip (AUTHOR), Hock, Stefan (AUTHOR), Mühlen, Iris (AUTHOR), Gerner, Stefan T. (AUTHOR), Sprügel, Maximilian I. (AUTHOR), Huttner, Hagen B. (AUTHOR), Schwab, Stefan (AUTHOR), Engelhorn, Tobias (AUTHOR), Doerfler, Arnd (AUTHOR) |
| Source: | Neurological Sciences. Apr2023, Vol. 44 Issue 4, p1193-1200. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 3 Graphs. |
| Subjects: | Endovascular surgery, Stroke, Ischemic stroke, Cerebral infarction, Prognosis |
| Geographic Terms: | Bavaria (Germany) |
| Abstract: | Purpose: Recent studies postulate a high prognostic value of the Alberta Stroke Programme Early CT Score (ASPECTS) applied on non-contrast whole-brain flat-detector CT (FDCT) after successful endovascular treatment (EVT). The aim of this study was the evaluation of long-term patient outcome after endovascular treatment using postinterventional FDCT. Methods: Using a local database (Stroke Research Consortium in Northern Bavaria, STAMINA), 517 patients with successful endovascular treatment (modified Thrombolysis in Cerebral Infarction (mTICI) ≥ 2B) due to acute ischaemic stroke (AIS) and large vessel occlusion (LVO) of the anterior circulation were recruited retrospectively. In all cases, non-contrast FDCT after EVT was analysed with special focus at ASPECTS. These results were correlated with the functional outcome in long-term (modified Rankin Scale (mRS) shift from pre-stroke to 90 days after discharge). Results: A significant difference in FDCT-ASPECTS compared to the subgroup of favourable vs. unfavourable outcome (Δ mRS) (median ASPECTS 10 (10–9) vs. median ASPECTS 9 (10–7); p = 0,001) could be demonstrated. Multivariable regression analysis revealed FDCT-ASPECTS (OR 0.234, 95% CI − 0.102–0.008, p = 0.022) along with the NHISS at admission (OR 0.169, 95% CI 0.003–0.018, p = 0.008) as independent factors for a favourable outcome. Cut-off point for a favourable outcome (Δ mRS) was identified at an ASPECTS ≥ 8 (sensitivity 90.6%, specificity 35%). Conclusion: For patients with LVO and successful EVT, FDCT-ASPECTS was found to be highly reliable in predicting long-term outcome. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 162507848 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Can flat-detector CT after successful endovascular treatment predict long-term outcome in patients with large vessel occlusion? An Alberta Stroke Programme Early CT Score–based study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Knott%2C+Michael%22">Knott, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoelter%2C+Philip%22">Hoelter, Philip</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hock%2C+Stefan%22">Hock, Stefan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mühlen%2C+Iris%22">Mühlen, Iris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gerner%2C+Stefan+T%2E%22">Gerner, Stefan T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sprügel%2C+Maximilian+I%2E%22">Sprügel, Maximilian I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huttner%2C+Hagen+B%2E%22">Huttner, Hagen B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schwab%2C+Stefan%22">Schwab, Stefan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Engelhorn%2C+Tobias%22">Engelhorn, Tobias</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doerfler%2C+Arnd%22">Doerfler, Arnd</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Apr2023, Vol. 44 Issue 4, p1193-1200. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Endovascular+surgery%22">Endovascular surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+infarction%22">Cerebral infarction</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Bavaria+%28Germany%29%22">Bavaria (Germany)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Recent studies postulate a high prognostic value of the Alberta Stroke Programme Early CT Score (ASPECTS) applied on non-contrast whole-brain flat-detector CT (FDCT) after successful endovascular treatment (EVT). The aim of this study was the evaluation of long-term patient outcome after endovascular treatment using postinterventional FDCT. Methods: Using a local database (Stroke Research Consortium in Northern Bavaria, STAMINA), 517 patients with successful endovascular treatment (modified Thrombolysis in Cerebral Infarction (mTICI) ≥ 2B) due to acute ischaemic stroke (AIS) and large vessel occlusion (LVO) of the anterior circulation were recruited retrospectively. In all cases, non-contrast FDCT after EVT was analysed with special focus at ASPECTS. These results were correlated with the functional outcome in long-term (modified Rankin Scale (mRS) shift from pre-stroke to 90 days after discharge). Results: A significant difference in FDCT-ASPECTS compared to the subgroup of favourable vs. unfavourable outcome (Δ mRS) (median ASPECTS 10 (10–9) vs. median ASPECTS 9 (10–7); p = 0,001) could be demonstrated. Multivariable regression analysis revealed FDCT-ASPECTS (OR 0.234, 95% CI − 0.102–0.008, p = 0.022) along with the NHISS at admission (OR 0.169, 95% CI 0.003–0.018, p = 0.008) as independent factors for a favourable outcome. Cut-off point for a favourable outcome (Δ mRS) was identified at an ASPECTS ≥ 8 (sensitivity 90.6%, specificity 35%). Conclusion: For patients with LVO and successful EVT, FDCT-ASPECTS was found to be highly reliable in predicting long-term outcome. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-022-06511-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1193 Subjects: – SubjectFull: Endovascular surgery Type: general – SubjectFull: Stroke Type: general – SubjectFull: Ischemic stroke Type: general – SubjectFull: Cerebral infarction Type: general – SubjectFull: Prognosis Type: general – SubjectFull: Bavaria (Germany) Type: general Titles: – TitleFull: Can flat-detector CT after successful endovascular treatment predict long-term outcome in patients with large vessel occlusion? An Alberta Stroke Programme Early CT Score–based study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Knott, Michael – PersonEntity: Name: NameFull: Hoelter, Philip – PersonEntity: Name: NameFull: Hock, Stefan – PersonEntity: Name: NameFull: Mühlen, Iris – PersonEntity: Name: NameFull: Gerner, Stefan T. – PersonEntity: Name: NameFull: Sprügel, Maximilian I. – PersonEntity: Name: NameFull: Huttner, Hagen B. – PersonEntity: Name: NameFull: Schwab, Stefan – PersonEntity: Name: NameFull: Engelhorn, Tobias – PersonEntity: Name: NameFull: Doerfler, Arnd IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 44 – Type: issue Value: 4 Titles: – TitleFull: Neurological Sciences Type: main |
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