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A case of severe increase of liver enzymes in a ATTRv patient after one year of inotersen treatment.

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Title: A case of severe increase of liver enzymes in a ATTRv patient after one year of inotersen treatment.
Authors: Severi, Daniele (AUTHOR), Palumbo, Giovanni (AUTHOR), Spina, Emanuele (AUTHOR), Iovino, Aniello (AUTHOR), Nolano, Maria (AUTHOR), Manganelli, Fiore (AUTHOR), Tozza, Stefano (AUTHOR)
Source: Neurological Sciences. Apr2023, Vol. 44 Issue 4, p1419-1422. 4p. 1 Graph.
Subjects: Liver enzymes, Hepatotoxicology, Transthyretin, IgA glomerulonephritis, Aminotransferases, Amyloidosis
Abstract: Background : Inotersen is an antisense oligonucleotide used to treat hereditary transthyretin amyloidosis (ATTRv). The most common drug-related adverse effects (AEs) include thrombocytopenia and glomerulonephritis. Hepatic damage is rare, but liver enzyme monitoring is mandatory. Case report: A 70-year-old man with ATTRv (Val30Met) treated with inotersen developed a severe increase of transaminases, with normal bilirubin and cholinesterase levels, that forced us to stop therapy. At the same time, other causes of acquired hepatitis were excluded, and the hypothesis of an inotersen-related hepatic toxicity was supported by the normalization of liver enzymes after 40 days from the drug interruption. Discussion: Our case showed that 1-year inotersen treatment can stabilize neurological impairment and even improve quality of life and suggests to carefully monitor liver enzymes in order to avoid an inotersen-related hepatic dysfunction. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A case of severe increase of liver enzymes in a ATTRv patient after one year of inotersen treatment.
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  Data: <searchLink fieldCode="AR" term="%22Severi%2C+Daniele%22">Severi, Daniele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palumbo%2C+Giovanni%22">Palumbo, Giovanni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spina%2C+Emanuele%22">Spina, Emanuele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iovino%2C+Aniello%22">Iovino, Aniello</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nolano%2C+Maria%22">Nolano, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manganelli%2C+Fiore%22">Manganelli, Fiore</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tozza%2C+Stefano%22">Tozza, Stefano</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Apr2023, Vol. 44 Issue 4, p1419-1422. 4p. 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Liver+enzymes%22">Liver enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatotoxicology%22">Hepatotoxicology</searchLink><br /><searchLink fieldCode="DE" term="%22Transthyretin%22">Transthyretin</searchLink><br /><searchLink fieldCode="DE" term="%22IgA+glomerulonephritis%22">IgA glomerulonephritis</searchLink><br /><searchLink fieldCode="DE" term="%22Aminotransferases%22">Aminotransferases</searchLink><br /><searchLink fieldCode="DE" term="%22Amyloidosis%22">Amyloidosis</searchLink>
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  Data: Background : Inotersen is an antisense oligonucleotide used to treat hereditary transthyretin amyloidosis (ATTRv). The most common drug-related adverse effects (AEs) include thrombocytopenia and glomerulonephritis. Hepatic damage is rare, but liver enzyme monitoring is mandatory. Case report: A 70-year-old man with ATTRv (Val30Met) treated with inotersen developed a severe increase of transaminases, with normal bilirubin and cholinesterase levels, that forced us to stop therapy. At the same time, other causes of acquired hepatitis were excluded, and the hypothesis of an inotersen-related hepatic toxicity was supported by the normalization of liver enzymes after 40 days from the drug interruption. Discussion: Our case showed that 1-year inotersen treatment can stabilize neurological impairment and even improve quality of life and suggests to carefully monitor liver enzymes in order to avoid an inotersen-related hepatic dysfunction. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-022-06568-w
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              Text: Apr2023
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