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Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review.

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Title: Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review.
Authors: Alblooshi, Salama (AUTHOR), Taylor, Mark (AUTHOR), Gill, Neeraj (AUTHOR)
Source: Australasian Psychiatry. Apr2023, Vol. 31 Issue 2, p165-173. 9p.
Subjects: Life change events, Anxiety, Menopause, Mental depression, Hot flashes
Abstract: Objective: To determine whether menopause elevates the risk for developing diagnostic depression and anxiety. Menopause-associated vasomotor symptoms such as insomnia and hot flushes are well recognized, but no systematic review of the psychological consequences of menopause has been undertaken. Menopause can be a time of social change for women, confounding any correlation. Methods: Using PRISMA methodology, we conducted a systematic review of all published (in English) original data examining a relationship between menopause and depression and anxiety. We ranked the quality of all included studies using Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria. Results: Twenty-two selected studies were summarized and compared, being eight cross-sectional surveys; one retrospective cohort, and 13 prospective cohort studies. Depression and anxiety are common during menopause and the post-menopause, with vasomotor symptoms and a prior history of major depression elevating risk of menopausal associated depression. Psychosocial factors also may increase risk of depression during menopause. Conclusions: Menopause increases vulnerability to depression and anxiety, perhaps via estrogen fluctuations affecting serotonin and GABA. Underlying neuroticism and contemporaneous adverse life events are also risk factors for menopausal decompensation with depression. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Does menopause elevate the risk for developing depression and anxiety? Results from a systematic review.
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  Data: <searchLink fieldCode="AR" term="%22Alblooshi%2C+Salama%22">Alblooshi, Salama</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taylor%2C+Mark%22">Taylor, Mark</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gill%2C+Neeraj%22">Gill, Neeraj</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Apr2023, Vol. 31 Issue 2, p165-173. 9p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Life+change+events%22">Life change events</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Menopause%22">Menopause</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Hot+flashes%22">Hot flashes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To determine whether menopause elevates the risk for developing diagnostic depression and anxiety. Menopause-associated vasomotor symptoms such as insomnia and hot flushes are well recognized, but no systematic review of the psychological consequences of menopause has been undertaken. Menopause can be a time of social change for women, confounding any correlation. Methods: Using PRISMA methodology, we conducted a systematic review of all published (in English) original data examining a relationship between menopause and depression and anxiety. We ranked the quality of all included studies using Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria. Results: Twenty-two selected studies were summarized and compared, being eight cross-sectional surveys; one retrospective cohort, and 13 prospective cohort studies. Depression and anxiety are common during menopause and the post-menopause, with vasomotor symptoms and a prior history of major depression elevating risk of menopausal associated depression. Psychosocial factors also may increase risk of depression during menopause. Conclusions: Menopause increases vulnerability to depression and anxiety, perhaps via estrogen fluctuations affecting serotonin and GABA. Underlying neuroticism and contemporaneous adverse life events are also risk factors for menopausal decompensation with depression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1177/10398562231165439
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        Text: English
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      – SubjectFull: Life change events
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Menopause
        Type: general
      – SubjectFull: Mental depression
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      – SubjectFull: Hot flashes
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              Text: Apr2023
              Type: published
              Y: 2023
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