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The predictive utility of atherosclerosis-related risk factors as predictors of the prognosis of idiopathic sudden sensorineural hearing loss in older adults.

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Title: The predictive utility of atherosclerosis-related risk factors as predictors of the prognosis of idiopathic sudden sensorineural hearing loss in older adults.
Authors: Chen, Zhi-Ting (AUTHOR), Guo, Yichen (AUTHOR), Zhang, Jing (AUTHOR), Huang, Xiaobing (AUTHOR), Wang, Jianhong (AUTHOR)
Source: Acta Oto-Laryngologica. Apr2023, Vol. 143 Issue 4, p296-300. 5p.
Subjects: Atherosclerosis complications, Hypertension epidemiology, Statistics, Predictive tests, Confidence intervals, Multiple regression analysis, Sensorineural hearing loss, Acquisition of data, Retrospective studies, Blood coagulation, Disease incidence, Comparative studies, Medical records, Descriptive statistics, Sensitivity & specificity (Statistics), Fibrin fibrinogen degradation products, Old age
Abstract (English): There have been few studies to date exploring prognostic outcomes associated with idiopathic sudden sensorineural hearing loss (ISSNHL) in order adults. This investigation was designed to explore the relationship between atherosclerosis-related risk factors and ISSNHL outcomes among older individuals. In total, 172 older adults diagnosed ISSNHL from 2016 to 2021 were retrospectively evaluated to compare demographic and clinical test results. Relative to healthy controls, ISSNHL patients exhibited significant differences in hypertension incidence and factors related to coagulation. With respect to prognosis, age, onset days, hypertension, the degree of hearing loss, type of hearing curve, fibrinogen and D-dimer levels were significant univariate prognostic factors, whereas multivariate logistic analysis showed that hypertension (p =.005) and D-dimer concentration (p =.000) were related to the treatment outcome of older ISSNHL patients. The area under the curve (AUC) for D-dimer levels was 0.795 (95% CI: 0.724–0.866). When using a D-dimer cut-off threshold value of 107.5 ng/mL, the sensitivity and specificity values of 77.0% and 76.7%. The present results indicate that hypertension incidence and D-dimer levels may be presented as an important prognostic indicator in older affected ISSNHL individuals. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 背景：迄今为止, 很少有研究探索老年人特发性突发性感音神经性听力损失 (ISSNHL)的预后结果。 目的：本研究旨在探讨老年人动脉粥样硬化相关危险因素与ISSNHL结果之间的关系。 材料和方法：对 2016 年至 2021 年诊断为 ISSNHL 的共 172 名老年人进行了回顾性评估, 以比较人口统计和临床测试结果。 结果：相对于健康对照组, ISSNHL 患者在高血压发生率和凝血相关因素方面表现出显著差异。 关于预后, 年龄、发病天数、高血压、听力损失程度、听力曲线类型、纤维蛋白原和 D-二聚体水平是显着的单变量预后因素, 而多变量逻辑分析显示高血压 (p =.005)和 D-二聚体浓度 (p =.000) 与老年 ISSNHL 患者的治疗结果相关。D-二聚体水平的曲线下面积 (AUC) 为 0.795（95% CI：0.724–0.866）。 当使用D-二聚体截止阈值107.5 ng/mL, 灵敏度和特异性值为 77.0%和 76.7%。 结论：目前的结果表明, 高血压发病率和 D-二聚体水平可能是老年 ISSNHL 患者的重要预后指标。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: The predictive utility of atherosclerosis-related risk factors as predictors of the prognosis of idiopathic sudden sensorineural hearing loss in older adults.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Zhi-Ting%22">Chen, Zhi-Ting</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Yichen%22">Guo, Yichen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing%22">Zhang, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Xiaobing%22">Huang, Xiaobing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jianhong%22">Wang, Jianhong</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Apr2023, Vol. 143 Issue 4, p296-300. 5p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Atherosclerosis+complications%22">Atherosclerosis complications</searchLink><br /><searchLink fieldCode="DE" term="%22Hypertension+epidemiology%22">Hypertension epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Predictive+tests%22">Predictive tests</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Sensorineural+hearing+loss%22">Sensorineural hearing loss</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data%22">Acquisition of data</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation%22">Blood coagulation</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+incidence%22">Disease incidence</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Fibrin+fibrinogen+degradation+products%22">Fibrin fibrinogen degradation products</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: There have been few studies to date exploring prognostic outcomes associated with idiopathic sudden sensorineural hearing loss (ISSNHL) in order adults. This investigation was designed to explore the relationship between atherosclerosis-related risk factors and ISSNHL outcomes among older individuals. In total, 172 older adults diagnosed ISSNHL from 2016 to 2021 were retrospectively evaluated to compare demographic and clinical test results. Relative to healthy controls, ISSNHL patients exhibited significant differences in hypertension incidence and factors related to coagulation. With respect to prognosis, age, onset days, hypertension, the degree of hearing loss, type of hearing curve, fibrinogen and D-dimer levels were significant univariate prognostic factors, whereas multivariate logistic analysis showed that hypertension (p =.005) and D-dimer concentration (p =.000) were related to the treatment outcome of older ISSNHL patients. The area under the curve (AUC) for D-dimer levels was 0.795 (95% CI: 0.724–0.866). When using a D-dimer cut-off threshold value of 107.5 ng/mL, the sensitivity and specificity values of 77.0% and 76.7%. The present results indicate that hypertension incidence and D-dimer levels may be presented as an important prognostic indicator in older affected ISSNHL individuals. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 背景：迄今为止, 很少有研究探索老年人特发性突发性感音神经性听力损失 (ISSNHL)的预后结果。 目的：本研究旨在探讨老年人动脉粥样硬化相关危险因素与ISSNHL结果之间的关系。 材料和方法：对 2016 年至 2021 年诊断为 ISSNHL 的共 172 名老年人进行了回顾性评估, 以比较人口统计和临床测试结果。 结果：相对于健康对照组, ISSNHL 患者在高血压发生率和凝血相关因素方面表现出显著差异。 关于预后, 年龄、发病天数、高血压、听力损失程度、听力曲线类型、纤维蛋白原和 D-二聚体水平是显着的单变量预后因素, 而多变量逻辑分析显示高血压 (p =.005)和 D-二聚体浓度 (p =.000) 与老年 ISSNHL 患者的治疗结果相关。D-二聚体水平的曲线下面积 (AUC) 为 0.795（95% CI：0.724–0.866）。 当使用D-二聚体截止阈值107.5 ng/mL, 灵敏度和特异性值为 77.0%和 76.7%。 结论：目前的结果表明, 高血压发病率和 D-二聚体水平可能是老年 ISSNHL 患者的重要预后指标。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=163520539
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2023.2185290
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 296
    Subjects:
      – SubjectFull: Atherosclerosis complications
        Type: general
      – SubjectFull: Hypertension epidemiology
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Predictive tests
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Sensorineural hearing loss
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Blood coagulation
        Type: general
      – SubjectFull: Disease incidence
        Type: general
      – SubjectFull: Comparative studies
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      – SubjectFull: Medical records
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Sensitivity & specificity (Statistics)
        Type: general
      – SubjectFull: Fibrin fibrinogen degradation products
        Type: general
      – SubjectFull: Old age
        Type: general
    Titles:
      – TitleFull: The predictive utility of atherosclerosis-related risk factors as predictors of the prognosis of idiopathic sudden sensorineural hearing loss in older adults.
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              Text: Apr2023
              Type: published
              Y: 2023
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