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Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent.

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Title: Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent.
Authors: Autio, Timo J. (AUTHOR), Atula, Timo (AUTHOR), Jouhi, Lauri (AUTHOR), Irjala, Heikki (AUTHOR), Halme, Elina (AUTHOR), Jouppila-Mättö, Anna (AUTHOR), Mäkitie, Antti (AUTHOR), Koivunen, Petri (AUTHOR)
Source: Acta Oto-Laryngologica. Apr2023, Vol. 143 Issue 4, p328-333. 6p.
Subjects: Head & neck cancer treatment, Evaluation of medical care, Patient aftercare, Time, Oropharyngeal cancer, Cancer relapse, Cancer patients, Papillomavirus diseases, Descriptive statistics, Research funding, Intention, Squamous cell carcinoma
Geographic Terms: Finland
Abstract (English): The increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers. The aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences. We analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated. Out of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months. Routine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences. [ABSTRACT FROM AUTHOR]
Abstract (Chinese): 背景：人乳头瘤病毒相关口咽鳞状细胞癌 (OPSCC) 治疗后接受监测的患者数量不断增加, 给医疗保健提供者带来了沉重负担。 目的：本研究的目的是探讨 OPSCC 在长期随访期间的复发：初级治疗后的部位、频率和时间点、治疗和结果。第二个目的是调查是否在常规随访中诊断出复发, 以及 p16 状态是否会对复发模式产生影响。 材料和方法：我们分析了 2000 年至 2009 年间接受治疗的芬兰 OPSCC 患者完成根治性治疗后 10 年随访期内的复发情况。调查了患者、肿瘤、治疗和随访等相关的参数。 结果：在前六个月内没有残留肿瘤的 495 名患者中, 有 71 名 (14%) 被诊断为复发, 其中 47 名是局部区域性的, 28 名接受了根治性治疗。 在复发病例中, 86% 是在初次治疗后的前 36 个月内诊断出来的。 36 个月后仅出现 10 例复发。 复发后的中位 OS 为 10.9 个月。 结论和意义：就检测 OPSCC 复发而言, 治疗后三年以上的常规随访似乎不起作用。 [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Timing and frequency of oropharyngeal squamous cell carcinoma recurrences after treatment with curative intent.
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  Data: <searchLink fieldCode="AR" term="%22Autio%2C+Timo+J%2E%22">Autio, Timo J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Atula%2C+Timo%22">Atula, Timo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jouhi%2C+Lauri%22">Jouhi, Lauri</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Irjala%2C+Heikki%22">Irjala, Heikki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Halme%2C+Elina%22">Halme, Elina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jouppila-Mättö%2C+Anna%22">Jouppila-Mättö, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mäkitie%2C+Antti%22">Mäkitie, Antti</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koivunen%2C+Petri%22">Koivunen, Petri</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Apr2023, Vol. 143 Issue 4, p328-333. 6p.
– Name: Subject
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  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Head+%26+neck+cancer+treatment%22">Head & neck cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+of+medical+care%22">Evaluation of medical care</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+aftercare%22">Patient aftercare</searchLink><br /><searchLink fieldCode="DE" term="%22Time%22">Time</searchLink><br /><searchLink fieldCode="DE" term="%22Oropharyngeal+cancer%22">Oropharyngeal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Papillomavirus+diseases%22">Papillomavirus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Intention%22">Intention</searchLink><br /><searchLink fieldCode="DE" term="%22Squamous+cell+carcinoma%22">Squamous cell carcinoma</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Finland%22">Finland</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: The increasing number of patients under surveillance after treatment of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) places a great burden on healthcare providers. The aim of this study was to explore OPSCC recurrences in a long follow-up period: their site, frequency and timepoint after primary treatment, treatment and outcome. The secondary aim was to investigate if the recurrences are diagnosed on routine follow-up visits, and if the p16 status will have an effect on the pattern of recurrences. We analyzed recurrences within a 10-year follow-up period after completed curatively intended treatment among OPSCC patients in Finland treated between 2000 and 2009. Patient-, tumor-, treatment- and follow-up -related parameters were investigated. Out of 495 patients with no residual tumor during the first six months, 71 (14%) were diagnosed with a recurrence, of which 47 were locoregional and 28 were treated with curative intent. Of the recurrences, 86% were diagnosed during the first 36 months after primary treatment. Only ten recurrences appeared after 36 months. The median OS after recurrence was 10.9 months. Routine follow-up longer than three years after treatment seems not to be effective in terms of detecting OPSCC recurrences. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Chinese)
  Group: Ab
  Data: 背景：人乳头瘤病毒相关口咽鳞状细胞癌 (OPSCC) 治疗后接受监测的患者数量不断增加, 给医疗保健提供者带来了沉重负担。 目的：本研究的目的是探讨 OPSCC 在长期随访期间的复发：初级治疗后的部位、频率和时间点、治疗和结果。第二个目的是调查是否在常规随访中诊断出复发, 以及 p16 状态是否会对复发模式产生影响。 材料和方法：我们分析了 2000 年至 2009 年间接受治疗的芬兰 OPSCC 患者完成根治性治疗后 10 年随访期内的复发情况。调查了患者、肿瘤、治疗和随访等相关的参数。 结果：在前六个月内没有残留肿瘤的 495 名患者中, 有 71 名 (14%) 被诊断为复发, 其中 47 名是局部区域性的, 28 名接受了根治性治疗。 在复发病例中, 86% 是在初次治疗后的前 36 个月内诊断出来的。 36 个月后仅出现 10 例复发。 复发后的中位 OS 为 10.9 个月。 结论和意义：就检测 OPSCC 复发而言, 治疗后三年以上的常规随访似乎不起作用。 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00016489.2023.2188892
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 6
        StartPage: 328
    Subjects:
      – SubjectFull: Head & neck cancer treatment
        Type: general
      – SubjectFull: Evaluation of medical care
        Type: general
      – SubjectFull: Patient aftercare
        Type: general
      – SubjectFull: Time
        Type: general
      – SubjectFull: Oropharyngeal cancer
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      – SubjectFull: Intention
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      – SubjectFull: Squamous cell carcinoma
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      – SubjectFull: Finland
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              Text: Apr2023
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