Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau181 levels in Aβ + patients within the Alzheimer's disease clinical spectrum.
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| Title: | Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau |
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| Authors: | Aiello, Edoardo Nicolò (AUTHOR), Verde, Federico (AUTHOR), Solca, Federica (AUTHOR), Milone, Ilaria (AUTHOR), Giacopuzzi Grigoli, Eleonora (AUTHOR), Dubini, Antonella (AUTHOR), Ratti, Antonia (AUTHOR), Ferrucci, Roberta (AUTHOR), Torresani, Erminio (AUTHOR), Priori, Alberto (AUTHOR), Ticozzi, Nicola (AUTHOR), Silani, Vincenzo (AUTHOR), Poletti, Barbara (AUTHOR) |
| Source: | Neurological Sciences. Jun2023, Vol. 44 Issue 6, p1979-1985. 7p. 1 Chart, 1 Graph. |
| Subjects: | Alzheimer's patients, Alzheimer's disease, Tau proteins, Tauopathies, Mild cognitive impairment |
| Abstract: | Background: The present study aimed to determine whether patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD), semantic verbal fluency (SVF), and the semantic-phonemic discrepancy (SPD) could predict abnormal cerebrospinal fluid (CSF) phosphorylated tau (P-tau181) and total tau (T-tau) levels. Methods: Phonemic verbal fluency (PVF) and SVF scores of N = 116 Aβ-positive patients with either MCI due to AD (N = 39) or probable AD dementia (ADD; N = 77) were retrospectively collected. The SPD was computed by subtracting PVF scores from SVF ones (positive and negative values corresponding to a semantic and phonemic advantage, respectively). Patients were cognitively phenotyped via a thorough test battery and profiled according to the amyloidosis/tauopathy/neurodegeneration (ATN) framework via CSF analyses. Two separate sets of logistic regressions were run to predict normal vs. abnormal P-tau181 and T-tau levels by encompassing as predictors SVF + PVF and SPD and covarying for demographic, disease-related features, and cognitive profile. Results: Lower SVF, but not PVF, scores, as well as a greater phonemic advantage (i.e., negative SPD values), predicted abnormal CSF P-tau181 levels (p ≤.01). Moreover, lower SVF scores were selectively predictive of abnormal CSF T-tau levels too (p =.016), while the SPD was not. Discussion: SVF and the SPD are able to predict tauopathy across the AD spectrum, thus supporting their status of valid, and sufficiently specific, cognitive markers of AD. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 163727418 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau<subscript>181</subscript> levels in Aβ + patients within the Alzheimer's disease clinical spectrum. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Aiello%2C+Edoardo+Nicolò%22">Aiello, Edoardo Nicolò</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verde%2C+Federico%22">Verde, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solca%2C+Federica%22">Solca, Federica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Milone%2C+Ilaria%22">Milone, Ilaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giacopuzzi+Grigoli%2C+Eleonora%22">Giacopuzzi Grigoli, Eleonora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dubini%2C+Antonella%22">Dubini, Antonella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ratti%2C+Antonia%22">Ratti, Antonia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferrucci%2C+Roberta%22">Ferrucci, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torresani%2C+Erminio%22">Torresani, Erminio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Priori%2C+Alberto%22">Priori, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ticozzi%2C+Nicola%22">Ticozzi, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silani%2C+Vincenzo%22">Silani, Vincenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poletti%2C+Barbara%22">Poletti, Barbara</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jun2023, Vol. 44 Issue 6, p1979-1985. 7p. 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Tau+proteins%22">Tau proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Tauopathies%22">Tauopathies</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The present study aimed to determine whether patients with mild cognitive impairment (MCI) and dementia due to Alzheimer's disease (AD), semantic verbal fluency (SVF), and the semantic-phonemic discrepancy (SPD) could predict abnormal cerebrospinal fluid (CSF) phosphorylated tau (P-tau181) and total tau (T-tau) levels. Methods: Phonemic verbal fluency (PVF) and SVF scores of N = 116 Aβ-positive patients with either MCI due to AD (N = 39) or probable AD dementia (ADD; N = 77) were retrospectively collected. The SPD was computed by subtracting PVF scores from SVF ones (positive and negative values corresponding to a semantic and phonemic advantage, respectively). Patients were cognitively phenotyped via a thorough test battery and profiled according to the amyloidosis/tauopathy/neurodegeneration (ATN) framework via CSF analyses. Two separate sets of logistic regressions were run to predict normal vs. abnormal P-tau181 and T-tau levels by encompassing as predictors SVF + PVF and SPD and covarying for demographic, disease-related features, and cognitive profile. Results: Lower SVF, but not PVF, scores, as well as a greater phonemic advantage (i.e., negative SPD values), predicted abnormal CSF P-tau181 levels (p ≤.01). Moreover, lower SVF scores were selectively predictive of abnormal CSF T-tau levels too (p =.016), while the SPD was not. Discussion: SVF and the SPD are able to predict tauopathy across the AD spectrum, thus supporting their status of valid, and sufficiently specific, cognitive markers of AD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=163727418 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-023-06643-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1979 Subjects: – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Tau proteins Type: general – SubjectFull: Tauopathies Type: general – SubjectFull: Mild cognitive impairment Type: general Titles: – TitleFull: Lower semantic fluency scores and a phonemic-over-semantic advantage predict abnormal CSF P-tau181 levels in Aβ + patients within the Alzheimer's disease clinical spectrum. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Aiello, Edoardo Nicolò – PersonEntity: Name: NameFull: Verde, Federico – PersonEntity: Name: NameFull: Solca, Federica – PersonEntity: Name: NameFull: Milone, Ilaria – PersonEntity: Name: NameFull: Giacopuzzi Grigoli, Eleonora – PersonEntity: Name: NameFull: Dubini, Antonella – PersonEntity: Name: NameFull: Ratti, Antonia – PersonEntity: Name: NameFull: Ferrucci, Roberta – PersonEntity: Name: NameFull: Torresani, Erminio – PersonEntity: Name: NameFull: Priori, Alberto – PersonEntity: Name: NameFull: Ticozzi, Nicola – PersonEntity: Name: NameFull: Silani, Vincenzo – PersonEntity: Name: NameFull: Poletti, Barbara IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 44 – Type: issue Value: 6 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
