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Pregnancy and birth outcomes among young women living with perinatally acquired HIV in Thailand and Vietnam.

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Title: Pregnancy and birth outcomes among young women living with perinatally acquired HIV in Thailand and Vietnam.
Authors: Lumbiganon, Pagakrong, Kariminia, Azar, Anugulruengkitt, Suvaporn, Ounchanum, Pradthana, Denjanta, Sukanda, Puthanakit, Thanyawee, Kosalaraksa, Pope, Sudjaritruk, Tavitiya, Detsakunathiwatchara, Chanidapa, Do, Viet Chau, Vu, An Thien, Nguyen, Lam Van, Thuy, Giang Thi Thanh, Suwanlerk, Tulathip, Sohn, Annette H., on behalf of IeDEA Asia-Pacific
Source: AIDS Care. Jun2023, Vol. 35 Issue 6, p818-823. 6p. 1 Diagram, 3 Charts.
Subjects: HIV infection transmission, HIV prevention, Childbirth, HIV-positive persons, Anti-HIV agents, Contraception, Infant formulas, Nevirapine, HIV infections, Confidence intervals, Social support, Transition to adulthood, Oral drug administration, Retrospective studies, RNA, Gestational age, Pregnancy outcomes, Low birth weight, Sex education, Descriptive statistics, CD4 lymphocyte count, Research funding, Vertical transmission (Communicable diseases), Longitudinal method, Adults, Children, Adolescence
Geographic Terms: Vietnam, Thailand
Abstract: We conducted a retrospective cohort study of pregnancy and infant outcomes in 670 adolescents and young adult women with perinatally acquired HIV (AYAPHIV), aged 15–24 years, in Thailand and Vietnam. Between January 2013 and December 2018, there were 52 pregnancies, for an incidence of 2.49 (95% CI 1.90-3.27) per 100 person-years. The median age at pregnancy was 17.7 years (IQR 16.8-18.9). Pregnant AYAPHIV had been on cART for a lifetime median of 9.8 years (IQR 7.3-12.4). At the time of conception, the median CD4 was 521 cells/mm3 (IQR 213-760), and 76% had HIV RNA ≤400 copies/ml. Of the 51 pregnancies with available outcomes, 90% resulted in live singleton births at a median gestational age of 38 weeks (IQR 37-39); 77% of mothers (n = 27/35) had HIV RNA ≤400 copies/ml at delivery. Among infants with available data, 50% (n = 21/42) were male and 29% (n = 12/42) were reported to be low birthweight (<2,500gm); none (n = 0/41) were breastfed. One infant was diagnosed with HIV. Our findings emphasize that efforts to strengthen reproductive health education, including contraception, pregnancy-related psychosocial support services, and prevention of vertical HIV transmission interventions, in our region are needed for adolescents with perinatally acquired HIV as they transition to young adults. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Pregnancy and birth outcomes among young women living with perinatally acquired HIV in Thailand and Vietnam.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22AIDS+Care%22&quot;&gt;AIDS Care&lt;/searchLink&gt;. Jun2023, Vol. 35 Issue 6, p818-823. 6p. 1 Diagram, 3 Charts.
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  Data: We conducted a retrospective cohort study of pregnancy and infant outcomes in 670 adolescents and young adult women with perinatally acquired HIV (AYAPHIV), aged 15–24 years, in Thailand and Vietnam. Between January 2013 and December 2018, there were 52 pregnancies, for an incidence of 2.49 (95% CI 1.90-3.27) per 100 person-years. The median age at pregnancy was 17.7 years (IQR 16.8-18.9). Pregnant AYAPHIV had been on cART for a lifetime median of 9.8 years (IQR 7.3-12.4). At the time of conception, the median CD4 was 521 cells/mm3 (IQR 213-760), and 76% had HIV RNA ≤400 copies/ml. Of the 51 pregnancies with available outcomes, 90% resulted in live singleton births at a median gestational age of 38 weeks (IQR 37-39); 77% of mothers (n = 27/35) had HIV RNA ≤400 copies/ml at delivery. Among infants with available data, 50% (n = 21/42) were male and 29% (n = 12/42) were reported to be low birthweight (&lt;2,500gm); none (n = 0/41) were breastfed. One infant was diagnosed with HIV. Our findings emphasize that efforts to strengthen reproductive health education, including contraception, pregnancy-related psychosocial support services, and prevention of vertical HIV transmission interventions, in our region are needed for adolescents with perinatally acquired HIV as they transition to young adults. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of AIDS Care is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=163763656
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09540121.2022.2132371
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 818
    Subjects:
      – SubjectFull: HIV infection transmission
        Type: general
      – SubjectFull: HIV prevention
        Type: general
      – SubjectFull: Childbirth
        Type: general
      – SubjectFull: HIV-positive persons
        Type: general
      – SubjectFull: Anti-HIV agents
        Type: general
      – SubjectFull: Contraception
        Type: general
      – SubjectFull: Infant formulas
        Type: general
      – SubjectFull: Nevirapine
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Social support
        Type: general
      – SubjectFull: Transition to adulthood
        Type: general
      – SubjectFull: Oral drug administration
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: RNA
        Type: general
      – SubjectFull: Gestational age
        Type: general
      – SubjectFull: Pregnancy outcomes
        Type: general
      – SubjectFull: Low birth weight
        Type: general
      – SubjectFull: Sex education
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: CD4 lymphocyte count
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Vertical transmission (Communicable diseases)
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Adults
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Vietnam
        Type: general
      – SubjectFull: Thailand
        Type: general
    Titles:
      – TitleFull: Pregnancy and birth outcomes among young women living with perinatally acquired HIV in Thailand and Vietnam.
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              M: 06
              Text: Jun2023
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