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Disclosure of HIV-serodiscordant relationships and association with viral suppression: results from the Positive Plus One study.

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Title: Disclosure of HIV-serodiscordant relationships and association with viral suppression: results from the Positive Plus One study.
Authors: Mendelsohn, Joshua B., Calzavara, Liviana, Bullock, Sandra, Iveniuk, James, Tan, Darrell H. S., Burchell, Ann N., Bourne, Adam, Lebouché, Bertrand, Daftary, Amrita, Moravan, Veronika, Loutfy, Mona, Conway, Brian
Source: AIDS Care. Jul2023, Vol. 35 Issue 7, p1037-1044. 8p. 5 Charts.
Subjects: Confidence intervals, Viral load, Cross-sectional method, HIV seroconversion, Self-disclosure, Treatment effectiveness, Research funding, Descriptive statistics, Chi-squared test, Sexual partners, Sociodemographic factors
Geographic Terms: Canada
Abstract: Background. Little is known about the effects of disclosure of HIV-serodiscordant relationships on clinical outcomes. We aimed to evaluate the effect of relationship disclosure on HIV viral suppression, and hypothesized that disclosure by HIV-positive and HIV-negative partners would be associated with viral suppression in the HIV-positive partner. Methods. We conducted a Canadian national online and telephone-administered survey of HIV-positive and HIV-negative partners in serodiscordant relationships. The primary outcome was self-reported viral suppression. Multivariable analyses were undertaken using Firth logistic regression. Results. We recruited 540 participants in current serodiscordant relationships (n = 228 HIV-negative; n = 312 HIV-positive). Similar proportions of HIV-positive and HIV-negative partners disclosed their relationship to healthcare professionals (82% v. 76%, p = 0.13). Among HIV-positive partners, disclosure of the relationship to healthcare professionals increased the odds of viral suppression (aOR = 4.7; CI: 2.13, 10.51) after adjusting for age, education, and relationship turmoil due to HIV. Increasing age (aOR = 1.28; 95% CI = 1.07, 1.55) and education (aOR = 2.43; 95% CI = 1.15, 5.26) were also associated with viral suppression. Among HIV-negative partners, relationship disclosure was not associated with viral suppression and HIV-negative heterosexual men were less likely to report that their HIV-positive partners were virally suppressed (aOR = 0.24; CI: 0.09, 0.61). Conclusions. Disclosure of HIV-serodiscordant status by HIV-positive participants to healthcare professionals was associated with increased odds of viral suppression. Similar effects were not evident among HIV-negative participants. Future work should explore factors that empower relationship disclosure and incorporate them into supportive services for HIV-serodiscordant relationships. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Disclosure of HIV-serodiscordant relationships and association with viral suppression: results from the Positive Plus One study.
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  Data: <searchLink fieldCode="AR" term="%22Mendelsohn%2C+Joshua+B%2E%22">Mendelsohn, Joshua B.</searchLink><br /><searchLink fieldCode="AR" term="%22Calzavara%2C+Liviana%22">Calzavara, Liviana</searchLink><br /><searchLink fieldCode="AR" term="%22Bullock%2C+Sandra%22">Bullock, Sandra</searchLink><br /><searchLink fieldCode="AR" term="%22Iveniuk%2C+James%22">Iveniuk, James</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+Darrell+H%2E+S%2E%22">Tan, Darrell H. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Burchell%2C+Ann+N%2E%22">Burchell, Ann N.</searchLink><br /><searchLink fieldCode="AR" term="%22Bourne%2C+Adam%22">Bourne, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Lebouché%2C+Bertrand%22">Lebouché, Bertrand</searchLink><br /><searchLink fieldCode="AR" term="%22Daftary%2C+Amrita%22">Daftary, Amrita</searchLink><br /><searchLink fieldCode="AR" term="%22Moravan%2C+Veronika%22">Moravan, Veronika</searchLink><br /><searchLink fieldCode="AR" term="%22Loutfy%2C+Mona%22">Loutfy, Mona</searchLink><br /><searchLink fieldCode="AR" term="%22Conway%2C+Brian%22">Conway, Brian</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Jul2023, Vol. 35 Issue 7, p1037-1044. 8p. 5 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+load%22">Viral load</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+seroconversion%22">HIV seroconversion</searchLink><br /><searchLink fieldCode="DE" term="%22Self-disclosure%22">Self-disclosure</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Sexual+partners%22">Sexual partners</searchLink><br /><searchLink fieldCode="DE" term="%22Sociodemographic+factors%22">Sociodemographic factors</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Canada%22">Canada</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background. Little is known about the effects of disclosure of HIV-serodiscordant relationships on clinical outcomes. We aimed to evaluate the effect of relationship disclosure on HIV viral suppression, and hypothesized that disclosure by HIV-positive and HIV-negative partners would be associated with viral suppression in the HIV-positive partner. Methods. We conducted a Canadian national online and telephone-administered survey of HIV-positive and HIV-negative partners in serodiscordant relationships. The primary outcome was self-reported viral suppression. Multivariable analyses were undertaken using Firth logistic regression. Results. We recruited 540 participants in current serodiscordant relationships (n = 228 HIV-negative; n = 312 HIV-positive). Similar proportions of HIV-positive and HIV-negative partners disclosed their relationship to healthcare professionals (82% v. 76%, p = 0.13). Among HIV-positive partners, disclosure of the relationship to healthcare professionals increased the odds of viral suppression (aOR = 4.7; CI: 2.13, 10.51) after adjusting for age, education, and relationship turmoil due to HIV. Increasing age (aOR = 1.28; 95% CI = 1.07, 1.55) and education (aOR = 2.43; 95% CI = 1.15, 5.26) were also associated with viral suppression. Among HIV-negative partners, relationship disclosure was not associated with viral suppression and HIV-negative heterosexual men were less likely to report that their HIV-positive partners were virally suppressed (aOR = 0.24; CI: 0.09, 0.61). Conclusions. Disclosure of HIV-serodiscordant status by HIV-positive participants to healthcare professionals was associated with increased odds of viral suppression. Similar effects were not evident among HIV-negative participants. Future work should explore factors that empower relationship disclosure and incorporate them into supportive services for HIV-serodiscordant relationships. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/09540121.2021.2019669
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 1037
    Subjects:
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Viral load
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      – SubjectFull: Cross-sectional method
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      – SubjectFull: HIV seroconversion
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      – SubjectFull: Self-disclosure
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Research funding
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      – SubjectFull: Canada
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              Text: Jul2023
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