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Obstetric complications and clinical presentation in first episode of psychosis.

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Title: Obstetric complications and clinical presentation in first episode of psychosis.
Authors: Verdolini, Norma (AUTHOR), Mezquida, Gisela (AUTHOR), Valli, Isabel (AUTHOR), Garcia-Rizo, Clemente (AUTHOR), Cuesta, Manuel (AUTHOR), Vieta, Eduard (AUTHOR), Bioque, Miquel (AUTHOR), Lobo, Antonio (AUTHOR), González-Pinto, Ana (AUTHOR), Pina-Camacho, Laura (AUTHOR), Corripio, Iluminada (AUTHOR), Garriga, Marina (AUTHOR), Baeza, Inmaculada (AUTHOR), Martínez-Sadurní, Laura (AUTHOR), Bitanihirwe, Byron (AUTHOR), Cannon, Mary (AUTHOR), Bernardo, Miquel (AUTHOR)
Source: Acta Neuropsychiatrica. Jun2023, Vol. 35 Issue 3, p156-164. 9p.
Subjects: Symptoms, Psychoses, Pregnancy complications, Fetal development, Etiology of diseases
Abstract: Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods: Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis–Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results: Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions: Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Obstetric complications and clinical presentation in first episode of psychosis.
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  Data: <searchLink fieldCode="AR" term="%22Verdolini%2C+Norma%22">Verdolini, Norma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mezquida%2C+Gisela%22">Mezquida, Gisela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valli%2C+Isabel%22">Valli, Isabel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garcia-Rizo%2C+Clemente%22">Garcia-Rizo, Clemente</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cuesta%2C+Manuel%22">Cuesta, Manuel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vieta%2C+Eduard%22">Vieta, Eduard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bioque%2C+Miquel%22">Bioque, Miquel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lobo%2C+Antonio%22">Lobo, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22González-Pinto%2C+Ana%22">González-Pinto, Ana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pina-Camacho%2C+Laura%22">Pina-Camacho, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Corripio%2C+Iluminada%22">Corripio, Iluminada</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garriga%2C+Marina%22">Garriga, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baeza%2C+Inmaculada%22">Baeza, Inmaculada</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martínez-Sadurní%2C+Laura%22">Martínez-Sadurní, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bitanihirwe%2C+Byron%22">Bitanihirwe, Byron</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cannon%2C+Mary%22">Cannon, Mary</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bernardo%2C+Miquel%22">Bernardo, Miquel</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neuropsychiatrica%22">Acta Neuropsychiatrica</searchLink>. Jun2023, Vol. 35 Issue 3, p156-164. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+complications%22">Pregnancy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Fetal+development%22">Fetal development</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink>
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  Data: Objective: Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Methods: Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis–Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Results: Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Conclusions: Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neuropsychiatrica is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/neu.2023.9
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        Text: English
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