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Sex‐based electroclinical differences and prognostic factors in epilepsy with eyelid myoclonia.

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Title: Sex‐based electroclinical differences and prognostic factors in epilepsy with eyelid myoclonia.
Authors: Cerulli Irelli, Emanuele (AUTHOR), Cocchi, Enrico (AUTHOR), Ramantani, Georgia (AUTHOR), Morano, Alessandra (AUTHOR), Riva, Antonella (AUTHOR), Caraballo, Roberto H. (AUTHOR), Giuliano, Loretta (AUTHOR), Yilmaz, Tülay (AUTHOR), Panagiotakaki, Eleni (AUTHOR), Operto, Francesca F. (AUTHOR), Giraldez, Beatriz Gonzalez (AUTHOR), Balestrini, Simona (AUTHOR), Silvennoinen, Katri (AUTHOR), Casciato, Sara (AUTHOR), Comajuan, Marion (AUTHOR), Fortunato, Francesco (AUTHOR), Giallonardo, Anna T. (AUTHOR), Gamirova, Rimma (AUTHOR), Coppola, Antonietta (AUTHOR), Di Gennaro, Giancarlo (AUTHOR)
Source: Epilepsia (Series 4). Jun2023, Vol. 64 Issue 6, pe105-e111. 7p.
Subjects: Epilepsy, Prognosis, Logistic regression analysis, Eyelids, Febrile seizures, Symptoms
Abstract: Although a striking female preponderance has been consistently reported in epilepsy with eyelid myoclonia (EEM), no study has specifically explored the variability of clinical presentation according to sex in this syndrome. Here, we aimed to investigate sex‐specific electroclinical differences and prognostic determinants in EEM. Data from 267 EEM patients were retrospectively analyzed by the EEM Study Group, and a dedicated multivariable logistic regression analysis was developed separately for each sex. We found that females with EEM showed a significantly higher rate of persistence of photosensitivity and eye closure sensitivity at the last visit, along with a higher prevalence of migraine with/without aura, whereas males with EEM presented a higher rate of borderline intellectual functioning/intellectual disability. In female patients, multivariable logistic regression analysis revealed age at epilepsy onset, eyelid myoclonia status epilepticus, psychiatric comorbidities, and catamenial seizures as significant predictors of drug resistance. In male patients, a history of febrile seizures was the only predictor of drug resistance. Hence, our study reveals sex‐specific differences in terms of both electroclinical features and prognostic factors. Our findings support the importance of a sex‐based personalized approach in epilepsy care and research, especially in genetic generalized epilepsies. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sex‐based electroclinical differences and prognostic factors in epilepsy with eyelid myoclonia.
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jun2023, Vol. 64 Issue 6, pe105-e111. 7p.
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– Name: Abstract
  Label: Abstract
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  Data: Although a striking female preponderance has been consistently reported in epilepsy with eyelid myoclonia (EEM), no study has specifically explored the variability of clinical presentation according to sex in this syndrome. Here, we aimed to investigate sex‐specific electroclinical differences and prognostic determinants in EEM. Data from 267 EEM patients were retrospectively analyzed by the EEM Study Group, and a dedicated multivariable logistic regression analysis was developed separately for each sex. We found that females with EEM showed a significantly higher rate of persistence of photosensitivity and eye closure sensitivity at the last visit, along with a higher prevalence of migraine with/without aura, whereas males with EEM presented a higher rate of borderline intellectual functioning/intellectual disability. In female patients, multivariable logistic regression analysis revealed age at epilepsy onset, eyelid myoclonia status epilepticus, psychiatric comorbidities, and catamenial seizures as significant predictors of drug resistance. In male patients, a history of febrile seizures was the only predictor of drug resistance. Hence, our study reveals sex‐specific differences in terms of both electroclinical features and prognostic factors. Our findings support the importance of a sex‐based personalized approach in epilepsy care and research, especially in genetic generalized epilepsies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/epi.17609
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: e105
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              Text: Jun2023
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