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The imbalance between Bregs, Tfh, and Tregs in patients with anti-N-methyl-D-aspartate receptor encephalitis.

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Title: The imbalance between Bregs, Tfh, and Tregs in patients with anti-N-methyl-D-aspartate receptor encephalitis.
Authors: Li, Yatong (AUTHOR), Zhang, Jing (AUTHOR), Liu, Lei (AUTHOR), Cui, Shilei (AUTHOR), Sun, Houliang (AUTHOR), Jiang, Hanqiu (AUTHOR), Guo, Yanjun (AUTHOR), Zhang, Jingxiao (AUTHOR), Xie, Zhuxiao (AUTHOR), Wang, Jiawei (AUTHOR)
Source: Neurological Sciences. Jul2023, Vol. 44 Issue 7, p2465-2474. 10p. 1 Chart, 5 Graphs.
Subjects: Anti-NMDA receptor encephalitis, Regulatory B cells, T helper cells, Neuromyelitis optica, Regulatory T cells, B cells
Abstract: Objective: To detect the alteration of regulatory B cells (Bregs), follicular helper T cells (Tfh), and regulatory T cells (Tregs) frequencies in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Analyze their association with clinical severity and activity, and explore the effects of different immunotherapies on those immune cell subsets. Methods: We enrolled 21 patients with anti-NMDAR encephalitis, 22 patients with neuromyelitis optica spectrum disorder (NMOSD), 14 patients with idiopathic intracranial hypertension (IIH), and 20 healthy controls (HC) in our study. The frequencies of various immune cell subsets were determined using flow cytometry. Results: Compared to patients with IIH and HC, the frequencies of CD24hiCD38hi transitional B cells as well as Tregs were significantly lower while the frequency of Tfh was significantly higher in patients with anti-NMDAR encephalitis. The frequency of CD24hiCD38hi transitional B cells was significantly lower in the acute stage than in the recovery stage, and was negatively correlated with the modified Rankin scale (mRS) and the clinical assessment scale for autoimmune encephalitis (CASE). The frequency of CD24hiCD38hi transitional B cells at the last follow-up after rituximab (RTX) treatment was significantly higher than those treated with oral immunosuppressants or untreated. There was no clear difference between anti-NMDAR encephalitis and NMOSD in the above immune cell subsets. Conclusion: We suggested that the frequencies of CD24hiCD38hi transitional B cells and Tregs were decreased while the frequency of Tfh was increased in patients with anti-NMDAR encephalitis. CD24hiCD38hi transitional B cells frequency may be a potential indicator to estimate the disease activity and severity. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The imbalance between Bregs, Tfh, and Tregs in patients with anti-N-methyl-D-aspartate receptor encephalitis.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Yatong%22">Li, Yatong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing%22">Zhang, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Lei%22">Liu, Lei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Shilei%22">Cui, Shilei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Houliang%22">Sun, Houliang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Hanqiu%22">Jiang, Hanqiu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Yanjun%22">Guo, Yanjun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jingxiao%22">Zhang, Jingxiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Zhuxiao%22">Xie, Zhuxiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jiawei%22">Wang, Jiawei</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jul2023, Vol. 44 Issue 7, p2465-2474. 10p. 1 Chart, 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Anti-NMDA+receptor+encephalitis%22">Anti-NMDA receptor encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Regulatory+B+cells%22">Regulatory B cells</searchLink><br /><searchLink fieldCode="DE" term="%22T+helper+cells%22">T helper cells</searchLink><br /><searchLink fieldCode="DE" term="%22Neuromyelitis+optica%22">Neuromyelitis optica</searchLink><br /><searchLink fieldCode="DE" term="%22Regulatory+T+cells%22">Regulatory T cells</searchLink><br /><searchLink fieldCode="DE" term="%22B+cells%22">B cells</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective: To detect the alteration of regulatory B cells (Bregs), follicular helper T cells (Tfh), and regulatory T cells (Tregs) frequencies in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. Analyze their association with clinical severity and activity, and explore the effects of different immunotherapies on those immune cell subsets. Methods: We enrolled 21 patients with anti-NMDAR encephalitis, 22 patients with neuromyelitis optica spectrum disorder (NMOSD), 14 patients with idiopathic intracranial hypertension (IIH), and 20 healthy controls (HC) in our study. The frequencies of various immune cell subsets were determined using flow cytometry. Results: Compared to patients with IIH and HC, the frequencies of CD24hiCD38hi transitional B cells as well as Tregs were significantly lower while the frequency of Tfh was significantly higher in patients with anti-NMDAR encephalitis. The frequency of CD24hiCD38hi transitional B cells was significantly lower in the acute stage than in the recovery stage, and was negatively correlated with the modified Rankin scale (mRS) and the clinical assessment scale for autoimmune encephalitis (CASE). The frequency of CD24hiCD38hi transitional B cells at the last follow-up after rituximab (RTX) treatment was significantly higher than those treated with oral immunosuppressants or untreated. There was no clear difference between anti-NMDAR encephalitis and NMOSD in the above immune cell subsets. Conclusion: We suggested that the frequencies of CD24hiCD38hi transitional B cells and Tregs were decreased while the frequency of Tfh was increased in patients with anti-NMDAR encephalitis. CD24hiCD38hi transitional B cells frequency may be a potential indicator to estimate the disease activity and severity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jul2023
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