Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression.
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| Title: | Examining associations between prenatal biomarkers of oxidative stress and ASD-related outcomes using quantile regression. |
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| Authors: | Carey, Meghan E., Rando, Juliette, Melnyk, Stepan, James, S Jill, Snyder, Nathaniel, Salafia, Carolyn, Croen, Lisa A., Fallin, M Daniele, Hertz-Picciotto, Irva, Volk, Heather, Newschaffer, Craig, Lyall, Kristen |
| Source: | Journal of Autism & Developmental Disorders. Aug2023, Vol. 53 Issue 8, p2975-2985. 11p. 2 Charts, 2 Graphs. |
| Subjects: | Autism risk factors, Biomarkers, Glutathione, Confidence intervals, Regression analysis, Oxidative stress, Risk assessment, Research funding, Descriptive statistics, Prenatal care, Tyrosine, Children, Pregnancy |
| Abstract: | We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling Social Responsiveness Scale (SRS) scores were examined using quantile regression. Increasing GSH:GSSG (suggesting decreasing OS) was associated with minor increases in SRS scores (50th percentile β: 1.78, 95% CI: 0.67, 3.06); no other associations were observed. Results from this cohort with increased risk for autism do not support a strong relationship between OS in late pregnancy and autism-related outcomes. Results may be specific to those with enriched autism risk; future work should consider other timepoints and biomarkers. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01623257 |
| DOI: | 10.1007/s10803-022-05625-9 |
