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Sestrin-2 and hypoxia-ınducible factor-1 alpha levels in major depressive disorder and its subtypes.

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Title: Sestrin-2 and hypoxia-ınducible factor-1 alpha levels in major depressive disorder and its subtypes.
Authors: Aslan, Esra (AUTHOR), Demir, Bahadır (AUTHOR), Ulusal, Hasan (AUTHOR), Şahin, Şengül (AUTHOR), Taysi, Seyithan (AUTHOR), Elboğa, Gülçin (AUTHOR), Altındağ, Abdurrahman (AUTHOR)
Source: Psychopharmacology. Aug2023, Vol. 240 Issue 8, p1691-1704. 14p. 1 Diagram, 8 Charts, 4 Graphs.
Subjects: Diagnostic & Statistical Manual of Mental Disorders (Book), Mental depression, Enzyme-linked immunosorbent assay, Beck Depression Inventory, Hyperbaric oxygenation, Anxiety
Abstract: Background: The objective of this study is to measure the levels of sestrin-2 (SESN2) and hypoxia-inducible factor-1 alpha (HIF-1α), which can be determinants in the relevant physiopathology and etiology, assessment of the clinical severity, and identification of new treatment targets in major depressive disorder (MDD) and its subtypes. Methods: A total of 230 volunteers, including 153 patients diagnosed with MDD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and 77 healthy controls, were included in the study. Of the MDD patients included in the study, 40 had melancholic features, 40 had anxious distress features, 38 had atypical features, and the remaining 35 had psychotic features. All participants were administered the Beck's Depression Inventory (BDI) and Clinical Global Impressions-Severity (CGI-S) scale. Serum SESN2 and HIF-1α levels of the participants were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: The HIF-1α and SESN2 values of the patient group were found to be significantly lower than those of the control group (p < 0.05). The HIF-1α and SESN2 values were significantly lower in patients with melancholic, anxious distress, and atypical features compared to the control group (p < 0.05). The HIF-1α and SESN2 levels did not differ significantly between patients with psychotic features and the control group (p > 0.05). Conclusion: The findings of the study suggested that knowledge of SESN2 and HIF-1α levels may contribute to the explanation of the etiology of MDD, objective assessment of the severity of the disease, and identification of new treatment targets. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Sestrin-2 and hypoxia-ınducible factor-1 alpha levels in major depressive disorder and its subtypes.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aslan%2C+Esra%22&quot;&gt;Aslan, Esra&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Demir%2C+Bahadır%22&quot;&gt;Demir, Bahadır&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ulusal%2C+Hasan%22&quot;&gt;Ulusal, Hasan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Şahin%2C+Şeng&#252;l%22&quot;&gt;Şahin, Şeng&#252;l&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Taysi%2C+Seyithan%22&quot;&gt;Taysi, Seyithan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Elboğa%2C+G&#252;l&#231;in%22&quot;&gt;Elboğa, G&#252;l&#231;in&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Altındağ%2C+Abdurrahman%22&quot;&gt;Altındağ, Abdurrahman&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychopharmacology%22&quot;&gt;Psychopharmacology&lt;/searchLink&gt;. Aug2023, Vol. 240 Issue 8, p1691-1704. 14p. 1 Diagram, 8 Charts, 4 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diagnostic+%26+Statistical+Manual+of+Mental+Disorders+%28Book%29%22&quot;&gt;Diagnostic &amp; Statistical Manual of Mental Disorders (Book)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Enzyme-linked+immunosorbent+assay%22&quot;&gt;Enzyme-linked immunosorbent assay&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Beck+Depression+Inventory%22&quot;&gt;Beck Depression Inventory&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hyperbaric+oxygenation%22&quot;&gt;Hyperbaric oxygenation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Anxiety%22&quot;&gt;Anxiety&lt;/searchLink&gt;
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  Data: Background: The objective of this study is to measure the levels of sestrin-2 (SESN2) and hypoxia-inducible factor-1 alpha (HIF-1α), which can be determinants in the relevant physiopathology and etiology, assessment of the clinical severity, and identification of new treatment targets in major depressive disorder (MDD) and its subtypes. Methods: A total of 230 volunteers, including 153 patients diagnosed with MDD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), and 77 healthy controls, were included in the study. Of the MDD patients included in the study, 40 had melancholic features, 40 had anxious distress features, 38 had atypical features, and the remaining 35 had psychotic features. All participants were administered the Beck&#39;s Depression Inventory (BDI) and Clinical Global Impressions-Severity (CGI-S) scale. Serum SESN2 and HIF-1α levels of the participants were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results: The HIF-1α and SESN2 values of the patient group were found to be significantly lower than those of the control group (p &lt; 0.05). The HIF-1α and SESN2 values were significantly lower in patients with melancholic, anxious distress, and atypical features compared to the control group (p &lt; 0.05). The HIF-1α and SESN2 levels did not differ significantly between patients with psychotic features and the control group (p &gt; 0.05). Conclusion: The findings of the study suggested that knowledge of SESN2 and HIF-1α levels may contribute to the explanation of the etiology of MDD, objective assessment of the severity of the disease, and identification of new treatment targets. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00213-023-06402-x
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        Text: English
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      – SubjectFull: Mental depression
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              Text: Aug2023
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