View in EDS HTML Full Text PDF Full Text

Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.

Saved in:
Bibliographic Details
Title: Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.
Authors: Wang, Siming (AUTHOR), Cai, Qihan (AUTHOR), Xu, Lu (AUTHOR), Sun, Yanan (AUTHOR), Wang, Mengmeng (AUTHOR), Wang, Yu (AUTHOR), Zhang, Lili (AUTHOR), Li, Keqing (AUTHOR), Ni, Zhiyu (AUTHOR)
Source: Psychopharmacology. Aug2023, Vol. 240 Issue 8, p1775-1787. 13p. 1 Diagram, 5 Graphs.
Subjects: Social defeat, Brain-derived neurotrophic factor, Serotonin uptake inhibitors, Postsynaptic density protein, Animal social behavior, Butyric acid, Glutamate receptors
Abstract: Rationale: The management of depression continues to be challenging despite the variety of available antidepressants. Herbal medicines are used in many cultures but lack stringent testing to understand their efficacy and mechanism of action. Isoalantolactone (LAT) from Elecampane (Inula helenium) improved the chronic social defeat stress (CSDS)-induced anhedonia-like phenotype in mice comparable to fluoxetine, a selective serotonin reuptake inhibitor (SSRI). Objectives: Compare the effects of LAT and fluoxetine on depression-like behaviors in mice exposed to CSDS. Result: The CSDS-induced decrease in protein expression of postsynaptic density (PSD95), brain derived neurotrophic factor (BDNF), and glutamate receptor subunit-1 (GluA1) in the prefrontal cortex was restored by LAT. LAT showed robust anti-inflammatory activity and can lessen the increase in IL-6 and TNF-α caused by CSDS. CSDS altered the gut microbiota at the taxonomic level, resulting in significant changes in α- and β-diversity. LAT treatment reestablished the bacterial abundance and diversity and increased the production of butyric acid in the gut that was inhibited by CSDS. The levels of butyric acid were negatively correlated with the abundance of Bacteroidetes, and positively correlated with those of Proteobacteria and Firmicutes across all treatment groups. Conclusions: The current data suggest that, similar to fluoxetine, LAT show antidepressant-like effects in mice exposed to CSDS through the modulation of the gut-brain axis. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 164947282
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Siming%22">Wang, Siming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cai%2C+Qihan%22">Cai, Qihan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Lu%22">Xu, Lu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Yanan%22">Sun, Yanan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Mengmeng%22">Wang, Mengmeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Yu%22">Wang, Yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Lili%22">Zhang, Lili</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Keqing%22">Li, Keqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ni%2C+Zhiyu%22">Ni, Zhiyu</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Aug2023, Vol. 240 Issue 8, p1775-1787. 13p. 1 Diagram, 5 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Social+defeat%22">Social defeat</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Postsynaptic+density+protein%22">Postsynaptic density protein</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+social+behavior%22">Animal social behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Butyric+acid%22">Butyric acid</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamate+receptors%22">Glutamate receptors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Rationale: The management of depression continues to be challenging despite the variety of available antidepressants. Herbal medicines are used in many cultures but lack stringent testing to understand their efficacy and mechanism of action. Isoalantolactone (LAT) from Elecampane (Inula helenium) improved the chronic social defeat stress (CSDS)-induced anhedonia-like phenotype in mice comparable to fluoxetine, a selective serotonin reuptake inhibitor (SSRI). Objectives: Compare the effects of LAT and fluoxetine on depression-like behaviors in mice exposed to CSDS. Result: The CSDS-induced decrease in protein expression of postsynaptic density (PSD95), brain derived neurotrophic factor (BDNF), and glutamate receptor subunit-1 (GluA1) in the prefrontal cortex was restored by LAT. LAT showed robust anti-inflammatory activity and can lessen the increase in IL-6 and TNF-α caused by CSDS. CSDS altered the gut microbiota at the taxonomic level, resulting in significant changes in α- and β-diversity. LAT treatment reestablished the bacterial abundance and diversity and increased the production of butyric acid in the gut that was inhibited by CSDS. The levels of butyric acid were negatively correlated with the abundance of Bacteroidetes, and positively correlated with those of Proteobacteria and Firmicutes across all treatment groups. Conclusions: The current data suggest that, similar to fluoxetine, LAT show antidepressant-like effects in mice exposed to CSDS through the modulation of the gut-brain axis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=164947282
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00213-023-06413-8
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 1775
    Subjects:
      – SubjectFull: Social defeat
        Type: general
      – SubjectFull: Brain-derived neurotrophic factor
        Type: general
      – SubjectFull: Serotonin uptake inhibitors
        Type: general
      – SubjectFull: Postsynaptic density protein
        Type: general
      – SubjectFull: Animal social behavior
        Type: general
      – SubjectFull: Butyric acid
        Type: general
      – SubjectFull: Glutamate receptors
        Type: general
    Titles:
      – TitleFull: Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wang, Siming
      – PersonEntity:
          Name:
            NameFull: Cai, Qihan
      – PersonEntity:
          Name:
            NameFull: Xu, Lu
      – PersonEntity:
          Name:
            NameFull: Sun, Yanan
      – PersonEntity:
          Name:
            NameFull: Wang, Mengmeng
      – PersonEntity:
          Name:
            NameFull: Wang, Yu
      – PersonEntity:
          Name:
            NameFull: Zhang, Lili
      – PersonEntity:
          Name:
            NameFull: Li, Keqing
      – PersonEntity:
          Name:
            NameFull: Ni, Zhiyu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 00333158
          Numbering:
            – Type: volume
              Value: 240
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Psychopharmacology
              Type: main
ResultId 1