View in EDS HTML Full Text PDF Full Text

High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience.

Saved in:
Bibliographic Details
Title: High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience.
Authors: Derome, Mélodie (AUTHOR), Machon, Sandra (AUTHOR), Barker, Holly (AUTHOR), Kozhuharova, Petya (AUTHOR), Orlov, Natasza (AUTHOR), Morgenroth, Elenor (AUTHOR), Hugdahl, Kenneth (AUTHOR), Allen, Paul (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Aug2023, Vol. 273 Issue 5, p1061-1072. 12p. 1 Color Photograph, 2 Charts, 1 Graph.
Subjects: Adverse childhood experiences, Young adults, Temporal lobe, Functional magnetic resonance imaging, Hippocampus (Brain)
Abstract: Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel sensory stimuli. Our objective was to investigate if CT was associated with changes in hippocampal and superior temporal gyrus functional activation and connectivity during a novelty detection task. Fifty-eight young adults were assigned to High-CT (n = 28) and Low-CT (n = 24) groups based on their scores on the childhood trauma questionnaire (CTQ) and underwent functional Magnetic Resonance Imaging during an auditory oddball task (AOT). Relative to the Low CT group, High CT participants showed reduced functional activation in the left hippocampus during the unpredictable tone condition of the AOT. Furthermore, in the High CT group, psychophysiological interaction analysis revealed hypoconnectivity between the hippocampus and temporal and medial regions. The present study indicates both altered hippocampal activation and hippocampal-temporal-prefrontal connectivity during novelty detection in individuals that experienced CT, similarly to that reported in psychosis risk populations. Early stressful experiences and environments may alter hippocampal function during salient events, mediating the relationship between childhood trauma and psychosis risk. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 165112327
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Derome%2C+Mélodie%22">Derome, Mélodie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Machon%2C+Sandra%22">Machon, Sandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barker%2C+Holly%22">Barker, Holly</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kozhuharova%2C+Petya%22">Kozhuharova, Petya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Orlov%2C+Natasza%22">Orlov, Natasza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morgenroth%2C+Elenor%22">Morgenroth, Elenor</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hugdahl%2C+Kenneth%22">Hugdahl, Kenneth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Allen%2C+Paul%22">Allen, Paul</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Aug2023, Vol. 273 Issue 5, p1061-1072. 12p. 1 Color Photograph, 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Adverse+childhood+experiences%22">Adverse childhood experiences</searchLink><br /><searchLink fieldCode="DE" term="%22Young+adults%22">Young adults</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobe%22">Temporal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel sensory stimuli. Our objective was to investigate if CT was associated with changes in hippocampal and superior temporal gyrus functional activation and connectivity during a novelty detection task. Fifty-eight young adults were assigned to High-CT (n = 28) and Low-CT (n = 24) groups based on their scores on the childhood trauma questionnaire (CTQ) and underwent functional Magnetic Resonance Imaging during an auditory oddball task (AOT). Relative to the Low CT group, High CT participants showed reduced functional activation in the left hippocampus during the unpredictable tone condition of the AOT. Furthermore, in the High CT group, psychophysiological interaction analysis revealed hypoconnectivity between the hippocampus and temporal and medial regions. The present study indicates both altered hippocampal activation and hippocampal-temporal-prefrontal connectivity during novelty detection in individuals that experienced CT, similarly to that reported in psychosis risk populations. Early stressful experiences and environments may alter hippocampal function during salient events, mediating the relationship between childhood trauma and psychosis risk. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=165112327
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-023-01564-3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 1061
    Subjects:
      – SubjectFull: Adverse childhood experiences
        Type: general
      – SubjectFull: Young adults
        Type: general
      – SubjectFull: Temporal lobe
        Type: general
      – SubjectFull: Functional magnetic resonance imaging
        Type: general
      – SubjectFull: Hippocampus (Brain)
        Type: general
    Titles:
      – TitleFull: High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Derome, Mélodie
      – PersonEntity:
          Name:
            NameFull: Machon, Sandra
      – PersonEntity:
          Name:
            NameFull: Barker, Holly
      – PersonEntity:
          Name:
            NameFull: Kozhuharova, Petya
      – PersonEntity:
          Name:
            NameFull: Orlov, Natasza
      – PersonEntity:
          Name:
            NameFull: Morgenroth, Elenor
      – PersonEntity:
          Name:
            NameFull: Hugdahl, Kenneth
      – PersonEntity:
          Name:
            NameFull: Allen, Paul
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 273
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1