Missing forms and dropout in the TME quality of life substudy.

Saved in:
Bibliographic Details
Title: Missing forms and dropout in the TME quality of life substudy.
Authors: Putter, H., Marijnen, C. A. M., Kranenbarg, E. Klein, van de Velde, C. J. H., Stiggelbout, A. M.
Source: Quality of Life Research. Apr2005, Vol. 14 Issue 3, p857-865. 9p.
Subjects: Quality of life, Health status indicators, Cancer patients, Rectal cancer, Medical electronics
Abstract: Objective: Missing forms may pose problems in health related quality of life (QOL) studies, because the absence of a QOL measure may be related to the patient's health and hence to the patient's QOL itself. Studying patterns of missingness, dropout, and the possible impact of missing data on QOL measures is an important step in reporting outcomes of QOL studies. We study patterns of dropout and evaluate the impact of missing forms in the TME QOL substudy.Methods: Patients with rectal cancer, randomized to receive either radiotherapy plus total mesorectal excision (TME) or TME only were included in the TME trial. QOL was evaluated in 1302 Dutch patients, before treatment, and 3, 6, 12, 18 and 24 months after surgery. Here only the visual analogue score (VAS) was studied.Results: At baseline, differences between VAS scores were found with respect to whether the QOL forms were dated before or after radiotherapy and surgery. Differences were small between different statistical methods accounting for dropout; only a cross-sectional analysis gave biased results.Conclusion: The results of the sensitivity analysis indicated that a linear mixed model analysis is a reliable and attractive approach for this study. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 16731230
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Missing forms and dropout in the TME quality of life substudy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Putter%2C+H%2E%22">Putter, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Marijnen%2C+C%2E+A%2E+M%2E%22">Marijnen, C. A. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kranenbarg%2C+E%2E+Klein%22">Kranenbarg, E. Klein</searchLink><br /><searchLink fieldCode="AR" term="%22van+de+Velde%2C+C%2E+J%2E+H%2E%22">van de Velde, C. J. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Stiggelbout%2C+A%2E+M%2E%22">Stiggelbout, A. M.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Apr2005, Vol. 14 Issue 3, p857-865. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Health+status+indicators%22">Health status indicators</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Rectal+cancer%22">Rectal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+electronics%22">Medical electronics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Objective: </bold>Missing forms may pose problems in health related quality of life (QOL) studies, because the absence of a QOL measure may be related to the patient's health and hence to the patient's QOL itself. Studying patterns of missingness, dropout, and the possible impact of missing data on QOL measures is an important step in reporting outcomes of QOL studies. We study patterns of dropout and evaluate the impact of missing forms in the TME QOL substudy.<bold>Methods: </bold>Patients with rectal cancer, randomized to receive either radiotherapy plus total mesorectal excision (TME) or TME only were included in the TME trial. QOL was evaluated in 1302 Dutch patients, before treatment, and 3, 6, 12, 18 and 24 months after surgery. Here only the visual analogue score (VAS) was studied.<bold>Results: </bold>At baseline, differences between VAS scores were found with respect to whether the QOL forms were dated before or after radiotherapy and surgery. Differences were small between different statistical methods accounting for dropout; only a cross-sectional analysis gave biased results.<bold>Conclusion: </bold>The results of the sensitivity analysis indicated that a linear mixed model analysis is a reliable and attractive approach for this study. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=16731230
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s11136-004-0834-7
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 857
    Subjects:
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Cancer patients
        Type: general
      – SubjectFull: Rectal cancer
        Type: general
      – SubjectFull: Medical electronics
        Type: general
    Titles:
      – TitleFull: Missing forms and dropout in the TME quality of life substudy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Putter, H.
      – PersonEntity:
          Name:
            NameFull: Marijnen, C. A. M.
      – PersonEntity:
          Name:
            NameFull: Kranenbarg, E. Klein
      – PersonEntity:
          Name:
            NameFull: van de Velde, C. J. H.
      – PersonEntity:
          Name:
            NameFull: Stiggelbout, A. M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2005
              Type: published
              Y: 2005
          Identifiers:
            – Type: issn-print
              Value: 09629343
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Quality of Life Research
              Type: main
ResultId 1