View in EDS HTML Full Text PDF Full Text

First-line tuberculosis therapy and drug-resistant Mycobacterium tuberculosis in prisons.

Saved in:
Bibliographic Details
Title: First-line tuberculosis therapy and drug-resistant Mycobacterium tuberculosis in prisons.
Authors: Coninx, R., Mathieu, C., Debacker, M., Mirzoev, F., Ismaelov, A., De Haller, R., Meddings, D.R.
Source: Lancet. 3/20/1999, Vol. 353 Issue 9157, p969-973. 5p. 4 Charts.
Subjects: Medical care of tuberculosis patients, Prisons, Drug resistance in microorganisms, Mycobacterial disease treatment
Geographic Terms: Azerbaijan, Baku (Azerbaijan)
Abstract: Background: We assessed a programme of tuberculosis control in a prison setting in Baku, Azerbaijan. The programme used first-line therapy and DOTS (directly observed treatment, short course).Methods: 467 patients had sputum-positive tuberculosis. Their treatment regimens followed WHO guidelines, and they had regular clinical examinations and dietary supplements. Isolates were tested by standard methods for resistance to isoniazid, rifampicin, ethambutol, and streptomycin in three laboratories. Treatment success was defined as three consecutive negative sputum smears at end of treatment. Factors independently associated with treatment failure were estimated by logistic regression.Findings: Drug-resistance data on admission were available for 131 patients. 55% of patients had strains of Mycobacterium tuberculosis resistant to two or more antibiotics. Mortality during treatment was 11%, and 13% of patients defaulted. Overall, treatment was successful in 54% of patients, and in 71% of those completing treatment. 104 patients completed a full treatment regimen and remained sputum-positive. Resistance to two or more antibiotics, a positive sputum result at the end of initial treatment, cavitary disease, and poor compliance were independently associated with treatment failure.Interpretation: The effectiveness of a DOTS programme with first-line therapy fell short of the 85% target set by WHO. First-line therapy may not be sufficient in settings with a high degree of resistance to antibiotics. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 1686430
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: First-line tuberculosis therapy and drug-resistant Mycobacterium tuberculosis in prisons.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Coninx%2C+R%2E%22">Coninx, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathieu%2C+C%2E%22">Mathieu, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Debacker%2C+M%2E%22">Debacker, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mirzoev%2C+F%2E%22">Mirzoev, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Ismaelov%2C+A%2E%22">Ismaelov, A.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Haller%2C+R%2E%22">De Haller, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Meddings%2C+D%2ER%2E%22">Meddings, D.R.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 3/20/1999, Vol. 353 Issue 9157, p969-973. 5p. 4 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medical+care+of+tuberculosis+patients%22">Medical care of tuberculosis patients</searchLink><br /><searchLink fieldCode="DE" term="%22Prisons%22">Prisons</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+microorganisms%22">Drug resistance in microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Mycobacterial+disease+treatment%22">Mycobacterial disease treatment</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Azerbaijan%22">Azerbaijan</searchLink><br /><searchLink fieldCode="DE" term="%22Baku+%28Azerbaijan%29%22">Baku (Azerbaijan)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Background: </bold>We assessed a programme of tuberculosis control in a prison setting in Baku, Azerbaijan. The programme used first-line therapy and DOTS (directly observed treatment, short course).<bold>Methods: </bold>467 patients had sputum-positive tuberculosis. Their treatment regimens followed WHO guidelines, and they had regular clinical examinations and dietary supplements. Isolates were tested by standard methods for resistance to isoniazid, rifampicin, ethambutol, and streptomycin in three laboratories. Treatment success was defined as three consecutive negative sputum smears at end of treatment. Factors independently associated with treatment failure were estimated by logistic regression.<bold>Findings: </bold>Drug-resistance data on admission were available for 131 patients. 55% of patients had strains of Mycobacterium tuberculosis resistant to two or more antibiotics. Mortality during treatment was 11%, and 13% of patients defaulted. Overall, treatment was successful in 54% of patients, and in 71% of those completing treatment. 104 patients completed a full treatment regimen and remained sputum-positive. Resistance to two or more antibiotics, a positive sputum result at the end of initial treatment, cavitary disease, and poor compliance were independently associated with treatment failure.<bold>Interpretation: </bold>The effectiveness of a DOTS programme with first-line therapy fell short of the 85% target set by WHO. First-line therapy may not be sufficient in settings with a high degree of resistance to antibiotics. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=1686430
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0140-6736(98)08341-X
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 969
    Subjects:
      – SubjectFull: Medical care of tuberculosis patients
        Type: general
      – SubjectFull: Prisons
        Type: general
      – SubjectFull: Drug resistance in microorganisms
        Type: general
      – SubjectFull: Mycobacterial disease treatment
        Type: general
      – SubjectFull: Azerbaijan
        Type: general
      – SubjectFull: Baku (Azerbaijan)
        Type: general
    Titles:
      – TitleFull: First-line tuberculosis therapy and drug-resistant Mycobacterium tuberculosis in prisons.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Coninx, R.
      – PersonEntity:
          Name:
            NameFull: Mathieu, C.
      – PersonEntity:
          Name:
            NameFull: Debacker, M.
      – PersonEntity:
          Name:
            NameFull: Mirzoev, F.
      – PersonEntity:
          Name:
            NameFull: Ismaelov, A.
      – PersonEntity:
          Name:
            NameFull: De Haller, R.
      – PersonEntity:
          Name:
            NameFull: Meddings, D.R.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 20
              M: 03
              Text: 3/20/1999
              Type: published
              Y: 1999
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 353
            – Type: issue
              Value: 9157
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1