Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.
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| Title: | Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. |
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| Authors: | You, Li-Ru, Lin, Fu-Jung, Lee, Christopher T., DeMayo, Francesco J., Tsai, Ming-Jer, Tsai, Sophia Y. |
| Source: | Nature. 5/5/2005, Vol. 435 Issue 7038, p98-104. 7p. |
| Subjects: | Growth factors, Peptides, Cytokines, Physical & theoretical chemistry, Endothelium, Transgenic animals |
| Abstract: | Arteries and veins are anatomically, functionally and molecularly distinct. The current model of arterial-venous identity proposes that binding of vascular endothelial growth factor to its heterodimeric receptor-Flk1 and neuropilin 1 (NP-1; also called Nrp1)-activates the Notch signalling pathway in the endothelium, causing induction of ephrin B2 expression and suppression of ephrin receptor B4 expression to establish arterial identity. Little is known about vein identity except that it involves ephrin receptor B4 expression, because Notch signalling is not activated in veins; an unresolved question is how vein identity is regulated. Here, we show that COUP-TFII (also known as Nr2f2), a member of the orphan nuclear receptor superfamily, is specifically expressed in venous but not arterial endothelium. Ablation of COUP-TFII in endothelial cells enables veins to acquire arterial characteristics, including the expression of arterial markers NP-1 and Notch signalling molecules, and the generation of haematopoietic cell clusters. Furthermore, ectopic expression of COUP-TFII in endothelial cells results in the fusion of veins and arteries in transgenic mouse embryos. Thus, COUP-TFII has a critical role in repressing Notch signalling to maintain vein identity, which suggests that vein identity is under genetic control and is not derived by a default pathway. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 16953748 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22You%2C+Li-Ru%22">You, Li-Ru</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Fu-Jung%22">Lin, Fu-Jung</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Christopher+T%2E%22">Lee, Christopher T.</searchLink><br /><searchLink fieldCode="AR" term="%22DeMayo%2C+Francesco+J%2E%22">DeMayo, Francesco J.</searchLink><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Ming-Jer%22">Tsai, Ming-Jer</searchLink><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Sophia+Y%2E%22">Tsai, Sophia Y.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 5/5/2005, Vol. 435 Issue 7038, p98-104. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Growth+factors%22">Growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Peptides%22">Peptides</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+%26+theoretical+chemistry%22">Physical & theoretical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelium%22">Endothelium</searchLink><br /><searchLink fieldCode="DE" term="%22Transgenic+animals%22">Transgenic animals</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Arteries and veins are anatomically, functionally and molecularly distinct. The current model of arterial-venous identity proposes that binding of vascular endothelial growth factor to its heterodimeric receptor-Flk1 and neuropilin 1 (NP-1; also called Nrp1)-activates the Notch signalling pathway in the endothelium, causing induction of ephrin B2 expression and suppression of ephrin receptor B4 expression to establish arterial identity. Little is known about vein identity except that it involves ephrin receptor B4 expression, because Notch signalling is not activated in veins; an unresolved question is how vein identity is regulated. Here, we show that COUP-TFII (also known as Nr2f2), a member of the orphan nuclear receptor superfamily, is specifically expressed in venous but not arterial endothelium. Ablation of COUP-TFII in endothelial cells enables veins to acquire arterial characteristics, including the expression of arterial markers NP-1 and Notch signalling molecules, and the generation of haematopoietic cell clusters. Furthermore, ectopic expression of COUP-TFII in endothelial cells results in the fusion of veins and arteries in transgenic mouse embryos. Thus, COUP-TFII has a critical role in repressing Notch signalling to maintain vein identity, which suggests that vein identity is under genetic control and is not derived by a default pathway. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature03511 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 98 Subjects: – SubjectFull: Growth factors Type: general – SubjectFull: Peptides Type: general – SubjectFull: Cytokines Type: general – SubjectFull: Physical & theoretical chemistry Type: general – SubjectFull: Endothelium Type: general – SubjectFull: Transgenic animals Type: general Titles: – TitleFull: Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: You, Li-Ru – PersonEntity: Name: NameFull: Lin, Fu-Jung – PersonEntity: Name: NameFull: Lee, Christopher T. – PersonEntity: Name: NameFull: DeMayo, Francesco J. – PersonEntity: Name: NameFull: Tsai, Ming-Jer – PersonEntity: Name: NameFull: Tsai, Sophia Y. IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 05 Text: 5/5/2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 435 – Type: issue Value: 7038 Titles: – TitleFull: Nature Type: main |
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