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Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study.

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Title: Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study.
Authors: Oh, Dae Jong (AUTHOR), Bae, Jong Bin (AUTHOR), Lipnicki, Darren M. (AUTHOR), Han, Ji Won (AUTHOR), Sachdev, Perminder S. (AUTHOR), Kim, Tae Hui (AUTHOR), Kwak, Kyung Phil (AUTHOR), Kim, Bong Jo (AUTHOR), Kim, Shin Gyeom (AUTHOR), Kim, Jeong Lan (AUTHOR), Moon, Seok Woo (AUTHOR), Park, Joon Hyuk (AUTHOR), Ryu, Seung‐Ho (AUTHOR), Youn, Jong Chul (AUTHOR), Lee, Dong Young (AUTHOR), Lee, Dong Woo (AUTHOR), Lee, Seok Bum (AUTHOR), Lee, Jung Jae (AUTHOR), Jhoo, Jin Hyeong (AUTHOR), Skoog, Ingmar (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Aug2023, Vol. 77 Issue 8, p449-456. 8p. 4 Charts.
Subjects: Disease risk factors, Alzheimer's disease, Cross-sectional method, Neuropsychological tests, Older people
Abstract: Background: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring. Methods: For this cross‐sectional study, we harmonized and pooled data for 17,194 older adults from nine population‐based cohorts of eight countries. These studies conducted face‐to‐face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring. Results: The mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15–1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31–2.26), but not with the risk of non‐AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15–1.97) and AD (OR = 1.80, 95% CI = 1.33–2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28–3.55 in males; OR = 1.68, 95% CI = 1.16–2.44 for females). Conclusions: Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study.
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  Data: <searchLink fieldCode="AR" term="%22Oh%2C+Dae+Jong%22">Oh, Dae Jong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bae%2C+Jong+Bin%22">Bae, Jong Bin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lipnicki%2C+Darren+M%2E%22">Lipnicki, Darren M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Ji+Won%22">Han, Ji Won</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sachdev%2C+Perminder+S%2E%22">Sachdev, Perminder S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Tae+Hui%22">Kim, Tae Hui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwak%2C+Kyung+Phil%22">Kwak, Kyung Phil</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Bong+Jo%22">Kim, Bong Jo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Shin+Gyeom%22">Kim, Shin Gyeom</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Jeong+Lan%22">Kim, Jeong Lan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moon%2C+Seok+Woo%22">Moon, Seok Woo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Joon+Hyuk%22">Park, Joon Hyuk</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ryu%2C+Seung‐Ho%22">Ryu, Seung‐Ho</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Youn%2C+Jong+Chul%22">Youn, Jong Chul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Dong+Young%22">Lee, Dong Young</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Dong+Woo%22">Lee, Dong Woo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Seok+Bum%22">Lee, Seok Bum</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Jung+Jae%22">Lee, Jung Jae</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jhoo%2C+Jin+Hyeong%22">Jhoo, Jin Hyeong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Skoog%2C+Ingmar%22">Skoog, Ingmar</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Aug2023, Vol. 77 Issue 8, p449-456. 8p. 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring. Methods: For this cross‐sectional study, we harmonized and pooled data for 17,194 older adults from nine population‐based cohorts of eight countries. These studies conducted face‐to‐face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring. Results: The mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15–1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31–2.26), but not with the risk of non‐AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15–1.97) and AD (OR = 1.80, 95% CI = 1.33–2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28–3.55 in males; OR = 1.68, 95% CI = 1.16–2.44 for females). Conclusions: Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/pcn.13561
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