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An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.

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Title: An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.
Authors: Jung, Kanghoon (AUTHOR), Chang, Minhyeok (AUTHOR), Steinecke, André (AUTHOR), Burke, Benjamin (AUTHOR), Choi, Youngjin (AUTHOR), Oisi, Yasuhiro (AUTHOR), Fitzpatrick, David (AUTHOR), Taniguchi, Hiroki (AUTHOR), Kwon, Hyung-Bae (AUTHOR)
Source: Nature Neuroscience. Aug2023, Vol. 26 Issue 8, p1379-1393. 15p.
Abstract: Genetically defined subgroups of inhibitory interneurons are thought to play distinct roles in learning, but heterogeneity within these subgroups has limited our understanding of the scope and nature of their specific contributions. Here we reveal that the chandelier cell (ChC), an interneuron type that specializes in inhibiting the axon-initial segment (AIS) of pyramidal neurons, establishes cortical microcircuits for organizing neural coding through selective axo-axonic synaptic plasticity. We found that organized motor control is mediated by enhanced population coding of direction-tuned premotor neurons, with tuning refined through suppression of irrelevant neuronal activity. ChCs contribute to learning-dependent refinements by providing selective inhibitory control over individual pyramidal neurons rather than global suppression. Quantitative analysis of structural plasticity across axo-axonic synapses revealed that ChCs redistributed inhibitory weights to individual pyramidal neurons during learning. These results demonstrate an adaptive logic of the inhibitory circuit motif responsible for organizing distributed neural representations. Thus, ChCs permit efficient cortical computation in a targeted cell-specific manner. Chandelier cells organize neural coding and mediate learning by establishing inhibitory circuit motifs over individual pyramidal neurons and suppressing irrelevant activity via adaptive axo-axonic synaptic plasticity, subserving efficient computation. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: An adaptive behavioral control motif mediated by cortical axo-axonic inhibition.
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  Data: <searchLink fieldCode="AR" term="%22Jung%2C+Kanghoon%22">Jung, Kanghoon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Minhyeok%22">Chang, Minhyeok</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Steinecke%2C+André%22">Steinecke, André</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burke%2C+Benjamin%22">Burke, Benjamin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Youngjin%22">Choi, Youngjin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oisi%2C+Yasuhiro%22">Oisi, Yasuhiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fitzpatrick%2C+David%22">Fitzpatrick, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taniguchi%2C+Hiroki%22">Taniguchi, Hiroki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon%2C+Hyung-Bae%22">Kwon, Hyung-Bae</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Aug2023, Vol. 26 Issue 8, p1379-1393. 15p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Genetically defined subgroups of inhibitory interneurons are thought to play distinct roles in learning, but heterogeneity within these subgroups has limited our understanding of the scope and nature of their specific contributions. Here we reveal that the chandelier cell (ChC), an interneuron type that specializes in inhibiting the axon-initial segment (AIS) of pyramidal neurons, establishes cortical microcircuits for organizing neural coding through selective axo-axonic synaptic plasticity. We found that organized motor control is mediated by enhanced population coding of direction-tuned premotor neurons, with tuning refined through suppression of irrelevant neuronal activity. ChCs contribute to learning-dependent refinements by providing selective inhibitory control over individual pyramidal neurons rather than global suppression. Quantitative analysis of structural plasticity across axo-axonic synapses revealed that ChCs redistributed inhibitory weights to individual pyramidal neurons during learning. These results demonstrate an adaptive logic of the inhibitory circuit motif responsible for organizing distributed neural representations. Thus, ChCs permit efficient cortical computation in a targeted cell-specific manner. Chandelier cells organize neural coding and mediate learning by establishing inhibitory circuit motifs over individual pyramidal neurons and suppressing irrelevant activity via adaptive axo-axonic synaptic plasticity, subserving efficient computation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Aug2023
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