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Shaping the course of early-onset Parkinson's disease: insights from a longitudinal cohort.

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Title: Shaping the course of early-onset Parkinson's disease: insights from a longitudinal cohort.
Authors: Bovenzi, Roberta (AUTHOR), Conti, Matteo (AUTHOR), Degoli, Giulia Rebecca (AUTHOR), Cerroni, Rocco (AUTHOR), Simonetta, Clara (AUTHOR), Liguori, Claudio (AUTHOR), Salimei, Chiara (AUTHOR), Pisani, Antonio (AUTHOR), Pierantozzi, Mariangela (AUTHOR), Stefani, Alessandro (AUTHOR), Mercuri, Nicola Biagio (AUTHOR), Schirinzi, Tommaso (AUTHOR)
Source: Neurological Sciences. Sep2023, Vol. 44 Issue 9, p3151-3159. 9p. 1 Diagram, 1 Chart, 2 Graphs.
Subjects: Parkinson's disease, Movement disorders, Longitudinal method, Disease progression
Abstract: Introduction: Early -onset Parkinson's disease (EOPD) labels those cases with onset earlier than fifty. Although peculiarities emerged either in clinical or pathological features, EOPD is managed alike typical, late-onset PD. A customized approach would be, instead, better appropriate. Accordingly, a deeper characterization of the clinical course, with an estimation of the disease progression rate, the therapy flow, and the main motor and non-motor complications occurrence, is needed. Methods: A longitudinal cohort of 193 EOPD patients (selected on a single-centre population of 2000 PD cases) was retrospectively analysed, providing descriptive statics on a series of clinical parameters (genetics, phenotype, comorbidities, therapies, motor and non-motor complications, marital and gender issues) and modelling the trajectories from diagnosis to 10 years later of both Hoehn and Yahr (H&Y) stage and levodopa equivalent daily dose (LEDD). Results: EOPD had a prevalence of 9.7%, including few monogenic cases. It mostly appeared as a motor syndrome, with asymmetric, rigid-akinetic presentation. H&Y linearly progressed with an increment of 0.92 points/10 years; LEDD flow had a non-linear trend, increasing of 526.90 mg/day in 0–5 years, and 166.83 mg/day in 5–10 years. Motor fluctuations started 6.5 ± 3.2 years from onset, affecting up to 80% of the cohort. Neuropsychiatric troubles interested the 50%, sexual complaints the 12%. Gender-specific motor disturbances emerged. Conclusion: We shaped EOPD course, modelling a "brain-first" PD subtype, slowly progressive, with non-linear dopaminergic requirement. Major burden mostly resulted from motor fluctuations, neuropsychiatric complications, sexual and marital complaints, with a considerable gender-effect. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Shaping the course of early-onset Parkinson's disease: insights from a longitudinal cohort.
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  Data: <searchLink fieldCode="AR" term="%22Bovenzi%2C+Roberta%22">Bovenzi, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conti%2C+Matteo%22">Conti, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Degoli%2C+Giulia+Rebecca%22">Degoli, Giulia Rebecca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cerroni%2C+Rocco%22">Cerroni, Rocco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Simonetta%2C+Clara%22">Simonetta, Clara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liguori%2C+Claudio%22">Liguori, Claudio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salimei%2C+Chiara%22">Salimei, Chiara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pisani%2C+Antonio%22">Pisani, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pierantozzi%2C+Mariangela%22">Pierantozzi, Mariangela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stefani%2C+Alessandro%22">Stefani, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mercuri%2C+Nicola+Biagio%22">Mercuri, Nicola Biagio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schirinzi%2C+Tommaso%22">Schirinzi, Tommaso</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Sep2023, Vol. 44 Issue 9, p3151-3159. 9p. 1 Diagram, 1 Chart, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Introduction: Early -onset Parkinson's disease (EOPD) labels those cases with onset earlier than fifty. Although peculiarities emerged either in clinical or pathological features, EOPD is managed alike typical, late-onset PD. A customized approach would be, instead, better appropriate. Accordingly, a deeper characterization of the clinical course, with an estimation of the disease progression rate, the therapy flow, and the main motor and non-motor complications occurrence, is needed. Methods: A longitudinal cohort of 193 EOPD patients (selected on a single-centre population of 2000 PD cases) was retrospectively analysed, providing descriptive statics on a series of clinical parameters (genetics, phenotype, comorbidities, therapies, motor and non-motor complications, marital and gender issues) and modelling the trajectories from diagnosis to 10 years later of both Hoehn and Yahr (H&Y) stage and levodopa equivalent daily dose (LEDD). Results: EOPD had a prevalence of 9.7%, including few monogenic cases. It mostly appeared as a motor syndrome, with asymmetric, rigid-akinetic presentation. H&Y linearly progressed with an increment of 0.92 points/10 years; LEDD flow had a non-linear trend, increasing of 526.90 mg/day in 0–5 years, and 166.83 mg/day in 5–10 years. Motor fluctuations started 6.5 ± 3.2 years from onset, affecting up to 80% of the cohort. Neuropsychiatric troubles interested the 50%, sexual complaints the 12%. Gender-specific motor disturbances emerged. Conclusion: We shaped EOPD course, modelling a "brain-first" PD subtype, slowly progressive, with non-linear dopaminergic requirement. Major burden mostly resulted from motor fluctuations, neuropsychiatric complications, sexual and marital complaints, with a considerable gender-effect. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-023-06826-5
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              Text: Sep2023
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