Influence of kidney function and CSF/serum albumin ratio on plasma Aβ42 and Aβ40 levels measured on a fully automated platform in patients with Alzheimer's disease.
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| Title: | Influence of kidney function and CSF/serum albumin ratio on plasma Aβ42 and Aβ40 levels measured on a fully automated platform in patients with Alzheimer's disease. |
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| Authors: | Verde, Federico (AUTHOR), Milone, Ilaria (AUTHOR), Dubini, Antonella (AUTHOR), Colombrita, Claudia (AUTHOR), Perego, Alberto (AUTHOR), Solca, Federica (AUTHOR), Maranzano, Alessio (AUTHOR), Ciusani, Emilio (AUTHOR), Poletti, Barbara (AUTHOR), Ratti, Antonia (AUTHOR), Torresani, Erminio (AUTHOR), Silani, Vincenzo (AUTHOR), Ticozzi, Nicola (AUTHOR) |
| Source: | Neurological Sciences. Sep2023, Vol. 44 Issue 9, p3287-3290. 4p. 1 Chart, 1 Graph. |
| Subjects: | Alzheimer's patients, Kidney physiology, Serum albumin, Alzheimer's disease, Glomerular filtration rate |
| Abstract: | Introduction: Alzheimer's disease (AD) is characterized by decreased cerebrospinal fluid (CSF) Aβ42 and Aβ42/Aβ40 ratio. Aβ peptides can now be measured also in plasma and are promising peripheral biomarkers for AD. We evaluated the relationships of plasma Aβ species with their CSF counterparts, kidney function, and serum/CSF albumin ratio (Q-Alb) in AD patients. Materials and methods: We measured plasma Aβ42 and Aβ40, as well as CSF AD biomarkers, with the fully automated Lumipulse platform in a cohort of N = 30 patients with clinical and neurochemical diagnosis of AD. Results: The two plasma Aβ peptides correlated strongly with each other (r = 0.7449), as did the corresponding CSF biomarkers (r = 0.7670). On the contrary, the positive correlations of plasma Aβ42, Aβ40, and Aβ42/Aβ40 ratio with their CSF counterparts and the negative correlation of plasma Aβ42/Aβ40 ratio with CSF P-tau181 were not statistically significant. Plasma levels of both Aβ species negatively correlated with estimated glomerular filtration rate (eGFR) (Aβ42: r = -0.4138; Aβ40: r = -0.6015), but plasma Aβ42/Aβ40 ratio did not. Q-Alb did not correlate with any plasma Aβ parameter. Discussion: Plasma Aβ42 and Aβ40 are critically influenced by kidney function; however, their ratio is advantageously spared from this effect. The lack of significant correlations between plasma Aβ species and their CSF counterparts is probably mainly due to small sample size and inclusion of only Aβ + individuals. Q-Alb is not a major determinant of plasma Aβ concentrations, highlighting the uncertainties about mechanisms of Aβ transfer between CNS and periphery. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 169871266 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Influence of kidney function and CSF/serum albumin ratio on plasma Aβ42 and Aβ40 levels measured on a fully automated platform in patients with Alzheimer's disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Verde%2C+Federico%22">Verde, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Milone%2C+Ilaria%22">Milone, Ilaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dubini%2C+Antonella%22">Dubini, Antonella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Colombrita%2C+Claudia%22">Colombrita, Claudia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perego%2C+Alberto%22">Perego, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solca%2C+Federica%22">Solca, Federica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maranzano%2C+Alessio%22">Maranzano, Alessio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ciusani%2C+Emilio%22">Ciusani, Emilio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poletti%2C+Barbara%22">Poletti, Barbara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ratti%2C+Antonia%22">Ratti, Antonia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torresani%2C+Erminio%22">Torresani, Erminio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silani%2C+Vincenzo%22">Silani, Vincenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ticozzi%2C+Nicola%22">Ticozzi, Nicola</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Sep2023, Vol. 44 Issue 9, p3287-3290. 4p. 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+physiology%22">Kidney physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Serum+albumin%22">Serum albumin</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Glomerular+filtration+rate%22">Glomerular filtration rate</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: Alzheimer's disease (AD) is characterized by decreased cerebrospinal fluid (CSF) Aβ42 and Aβ42/Aβ40 ratio. Aβ peptides can now be measured also in plasma and are promising peripheral biomarkers for AD. We evaluated the relationships of plasma Aβ species with their CSF counterparts, kidney function, and serum/CSF albumin ratio (Q-Alb) in AD patients. Materials and methods: We measured plasma Aβ42 and Aβ40, as well as CSF AD biomarkers, with the fully automated Lumipulse platform in a cohort of N = 30 patients with clinical and neurochemical diagnosis of AD. Results: The two plasma Aβ peptides correlated strongly with each other (r = 0.7449), as did the corresponding CSF biomarkers (r = 0.7670). On the contrary, the positive correlations of plasma Aβ42, Aβ40, and Aβ42/Aβ40 ratio with their CSF counterparts and the negative correlation of plasma Aβ42/Aβ40 ratio with CSF P-tau181 were not statistically significant. Plasma levels of both Aβ species negatively correlated with estimated glomerular filtration rate (eGFR) (Aβ42: r = -0.4138; Aβ40: r = -0.6015), but plasma Aβ42/Aβ40 ratio did not. Q-Alb did not correlate with any plasma Aβ parameter. Discussion: Plasma Aβ42 and Aβ40 are critically influenced by kidney function; however, their ratio is advantageously spared from this effect. The lack of significant correlations between plasma Aβ species and their CSF counterparts is probably mainly due to small sample size and inclusion of only Aβ + individuals. Q-Alb is not a major determinant of plasma Aβ concentrations, highlighting the uncertainties about mechanisms of Aβ transfer between CNS and periphery. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=169871266 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-023-06882-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 3287 Subjects: – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Kidney physiology Type: general – SubjectFull: Serum albumin Type: general – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Glomerular filtration rate Type: general Titles: – TitleFull: Influence of kidney function and CSF/serum albumin ratio on plasma Aβ42 and Aβ40 levels measured on a fully automated platform in patients with Alzheimer's disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Verde, Federico – PersonEntity: Name: NameFull: Milone, Ilaria – PersonEntity: Name: NameFull: Dubini, Antonella – PersonEntity: Name: NameFull: Colombrita, Claudia – PersonEntity: Name: NameFull: Perego, Alberto – PersonEntity: Name: NameFull: Solca, Federica – PersonEntity: Name: NameFull: Maranzano, Alessio – PersonEntity: Name: NameFull: Ciusani, Emilio – PersonEntity: Name: NameFull: Poletti, Barbara – PersonEntity: Name: NameFull: Ratti, Antonia – PersonEntity: Name: NameFull: Torresani, Erminio – PersonEntity: Name: NameFull: Silani, Vincenzo – PersonEntity: Name: NameFull: Ticozzi, Nicola IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 44 – Type: issue Value: 9 Titles: – TitleFull: Neurological Sciences Type: main |
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