A pilot randomized controlled trial of transdiagnostic network‐informed personalized treatment for eating disorders versus enhanced cognitive behavioral therapy.
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| Title: | A pilot randomized controlled trial of transdiagnostic network‐informed personalized treatment for eating disorders versus enhanced cognitive behavioral therapy. |
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| Authors: | Butler, Rachel M., Ortiz, Anna Marie L., Pennesi, Jamie‐Lee, Crumby, Emma K., Cusack, Claire E., Levinson, Cheri A. |
| Source: | International Journal of Eating Disorders. Aug2023, Vol. 56 Issue 8, p1674-1680. 7p. 1 Chart. |
| Subjects: | Treatment of eating disorders, Pilot projects, Individualized medicine, Treatment effectiveness, Randomized controlled trials, Cognitive therapy |
| Abstract: | Objective: Eating disorders (EDs) are serious mental illnesses with high mortality and relapse rates and carry significant societal and personal costs. Nevertheless, there are few evidence‐based treatments available. One aspect that makes treatment difficult is the high heterogeneity in symptom presentation. This heterogeneity makes it challenging for clinicians to identify pertinent treatment targets. Personalized treatment based on idiographic models may be well‐suited to address this heterogeneity, and, in turn, presumably improve treatment outcomes. Methods: In the current randomized controlled trial, participants will be randomly assigned to either 20 sessions of enhanced cognitive behavioral therapy (CBT‐E) or transdiagnostic network‐informed personalized treatment for EDs (T‐NIPT‐ED). Assessment of ED symptoms, clinical impairment, and quality of life will occur at pre‐, mid‐, posttreatment, and 1‐month follow‐up. Results: We will examine the acceptability and feasibility of T‐NIPT‐ED compared to CBT‐E. We also will test the initial clinical efficacy of T‐NIPT‐ED versus CBT‐E on clinical outcomes (i.e., ED symptoms and quality of life). Finally, we will test if the network‐identified precision targets are the mechanisms of change. Discussion: Ultimately, this research may inform the development and dissemination of evidence‐based personalized treatments for EDs and serve as an exemplar for personalized treatment development across the broader field of psychiatry. Public Significance: Current evidence‐based treatments for eating disorders result in low rates of recovery, especially for adults with AN. Our study aims to test the feasibility, acceptability, and clinical efficacy of a data‐driven, individualized approach to ED treatment, network‐informed personalized treatment, compared to the current evidence‐based treatment for EDs, Enhanced CBT. Findings have the potential to improve treatment outcomes for EDs by identifying and targeting core symptoms maintaining EDs. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 169914889 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A pilot randomized controlled trial of transdiagnostic network‐informed personalized treatment for eating disorders versus enhanced cognitive behavioral therapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Butler%2C+Rachel+M%2E%22">Butler, Rachel M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ortiz%2C+Anna+Marie+L%2E%22">Ortiz, Anna Marie L.</searchLink><br /><searchLink fieldCode="AR" term="%22Pennesi%2C+Jamie‐Lee%22">Pennesi, Jamie‐Lee</searchLink><br /><searchLink fieldCode="AR" term="%22Crumby%2C+Emma+K%2E%22">Crumby, Emma K.</searchLink><br /><searchLink fieldCode="AR" term="%22Cusack%2C+Claire+E%2E%22">Cusack, Claire E.</searchLink><br /><searchLink fieldCode="AR" term="%22Levinson%2C+Cheri+A%2E%22">Levinson, Cheri A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Eating+Disorders%22">International Journal of Eating Disorders</searchLink>. Aug2023, Vol. 56 Issue 8, p1674-1680. 7p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Treatment+of+eating+disorders%22">Treatment of eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+medicine%22">Individualized medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: Eating disorders (EDs) are serious mental illnesses with high mortality and relapse rates and carry significant societal and personal costs. Nevertheless, there are few evidence‐based treatments available. One aspect that makes treatment difficult is the high heterogeneity in symptom presentation. This heterogeneity makes it challenging for clinicians to identify pertinent treatment targets. Personalized treatment based on idiographic models may be well‐suited to address this heterogeneity, and, in turn, presumably improve treatment outcomes. Methods: In the current randomized controlled trial, participants will be randomly assigned to either 20 sessions of enhanced cognitive behavioral therapy (CBT‐E) or transdiagnostic network‐informed personalized treatment for EDs (T‐NIPT‐ED). Assessment of ED symptoms, clinical impairment, and quality of life will occur at pre‐, mid‐, posttreatment, and 1‐month follow‐up. Results: We will examine the acceptability and feasibility of T‐NIPT‐ED compared to CBT‐E. We also will test the initial clinical efficacy of T‐NIPT‐ED versus CBT‐E on clinical outcomes (i.e., ED symptoms and quality of life). Finally, we will test if the network‐identified precision targets are the mechanisms of change. Discussion: Ultimately, this research may inform the development and dissemination of evidence‐based personalized treatments for EDs and serve as an exemplar for personalized treatment development across the broader field of psychiatry. Public Significance: Current evidence‐based treatments for eating disorders result in low rates of recovery, especially for adults with AN. Our study aims to test the feasibility, acceptability, and clinical efficacy of a data‐driven, individualized approach to ED treatment, network‐informed personalized treatment, compared to the current evidence‐based treatment for EDs, Enhanced CBT. Findings have the potential to improve treatment outcomes for EDs by identifying and targeting core symptoms maintaining EDs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=169914889 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/eat.23982 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1674 Subjects: – SubjectFull: Treatment of eating disorders Type: general – SubjectFull: Pilot projects Type: general – SubjectFull: Individualized medicine Type: general – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Randomized controlled trials Type: general – SubjectFull: Cognitive therapy Type: general Titles: – TitleFull: A pilot randomized controlled trial of transdiagnostic network‐informed personalized treatment for eating disorders versus enhanced cognitive behavioral therapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Butler, Rachel M. – PersonEntity: Name: NameFull: Ortiz, Anna Marie L. – PersonEntity: Name: NameFull: Pennesi, Jamie‐Lee – PersonEntity: Name: NameFull: Crumby, Emma K. – PersonEntity: Name: NameFull: Cusack, Claire E. – PersonEntity: Name: NameFull: Levinson, Cheri A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 02763478 Numbering: – Type: volume Value: 56 – Type: issue Value: 8 Titles: – TitleFull: International Journal of Eating Disorders Type: main |
| ResultId | 1 |
