The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study.
Saved in:
| Title: | The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study. |
|---|---|
| Authors: | Sideli, Lucia (AUTHOR), Aas, Monica (AUTHOR), Quattrone, Diego (AUTHOR), La Barbera, Daniele (AUTHOR), La Cascia, Caterina (AUTHOR), Ferraro, Laura (AUTHOR), Alameda, Luis (AUTHOR), Velthorst, Eva (AUTHOR), Trotta, Giulia (AUTHOR), Tripoli, Giada (AUTHOR), Schimmenti, Adriano (AUTHOR), Fontana, Andrea (AUTHOR), Gayer-Anderson, Charlotte (AUTHOR), Stilo, Simona (AUTHOR), Seminerio, Fabio (AUTHOR), Sartorio, Crocettarachele (AUTHOR), Marrazzo, Giovanna (AUTHOR), Lasalvia, Antonio (AUTHOR), Tosato, Sarah (AUTHOR), Tarricone, Ilaria (AUTHOR) |
| Source: | Social Psychiatry & Psychiatric Epidemiology. Oct2023, Vol. 58 Issue 10, p1573-1580. 8p. |
| Subjects: | Child abuse, Disease risk factors, Monogenic & polygenic inheritance (Genetics), Intelligence levels, Gene expression |
| Abstract: | This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood. [ABSTRACT FROM AUTHOR] |
| Copyright of Social Psychiatry & Psychiatric Epidemiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
Be the first to leave a comment!
