View in EDS HTML Full Text PDF Full Text

Discovery of eQTL Alleles Associated with Autism Spectrum Disorder: A Case–Control Study.

Saved in:
Bibliographic Details
Title: Discovery of eQTL Alleles Associated with Autism Spectrum Disorder: A Case–Control Study.
Authors: Hickman, Allison R., Selee, Bradley, Pauly, Rini, Husain, Benafsh, Hang, Yuqing, Feltus, Frank Alex
Source: Journal of Autism & Developmental Disorders. Sep2023, Vol. 53 Issue 9, p3595-3612. 18p. 2 Diagrams, 4 Charts, 4 Graphs.
Subjects: Genetics of autism, Brain, Alleles, Case-control method, Race, Fisher exact test, Gene expression, Sex distribution, Genotypes, Genetic markers, Descriptive statistics, Artificial neural networks, Secondary analysis
Abstract: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by challenges in social communication as well as repetitive or restrictive behaviors. Many genetic associations with ASD have been identified, but most associations occur in a fraction of the ASD population. Here, we searched for eQTL-associated DNA variants with significantly different allele distributions between ASD-affected and control. Thirty significant DNA variants associated with 174 tissue-specific eQTLs from ASD individuals in the SPARK project were identified. Several significant variants fell within brain-specific regulatory regions or had been associated with a significant change in gene expression in the brain. These eQTLs are a new class of biomarkers that could control the myriad of brain and non-brain phenotypic traits seen in ASD-affected individuals. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 170899323
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of eQTL Alleles Associated with Autism Spectrum Disorder: A Case–Control Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hickman%2C+Allison+R%2E%22">Hickman, Allison R.</searchLink><br /><searchLink fieldCode="AR" term="%22Selee%2C+Bradley%22">Selee, Bradley</searchLink><br /><searchLink fieldCode="AR" term="%22Pauly%2C+Rini%22">Pauly, Rini</searchLink><br /><searchLink fieldCode="AR" term="%22Husain%2C+Benafsh%22">Husain, Benafsh</searchLink><br /><searchLink fieldCode="AR" term="%22Hang%2C+Yuqing%22">Hang, Yuqing</searchLink><br /><searchLink fieldCode="AR" term="%22Feltus%2C+Frank+Alex%22">Feltus, Frank Alex</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Sep2023, Vol. 53 Issue 9, p3595-3612. 18p. 2 Diagrams, 4 Charts, 4 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Genetics+of+autism%22">Genetics of autism</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Alleles%22">Alleles</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Race%22">Race</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+markers%22">Genetic markers</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+neural+networks%22">Artificial neural networks</searchLink><br /><searchLink fieldCode="DE" term="%22Secondary+analysis%22">Secondary analysis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by challenges in social communication as well as repetitive or restrictive behaviors. Many genetic associations with ASD have been identified, but most associations occur in a fraction of the ASD population. Here, we searched for eQTL-associated DNA variants with significantly different allele distributions between ASD-affected and control. Thirty significant DNA variants associated with 174 tissue-specific eQTLs from ASD individuals in the SPARK project were identified. Several significant variants fell within brain-specific regulatory regions or had been associated with a significant change in gene expression in the brain. These eQTLs are a new class of biomarkers that could control the myriad of brain and non-brain phenotypic traits seen in ASD-affected individuals. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=170899323
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-022-05631-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 3595
    Subjects:
      – SubjectFull: Genetics of autism
        Type: general
      – SubjectFull: Brain
        Type: general
      – SubjectFull: Alleles
        Type: general
      – SubjectFull: Case-control method
        Type: general
      – SubjectFull: Race
        Type: general
      – SubjectFull: Fisher exact test
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Genotypes
        Type: general
      – SubjectFull: Genetic markers
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Artificial neural networks
        Type: general
      – SubjectFull: Secondary analysis
        Type: general
    Titles:
      – TitleFull: Discovery of eQTL Alleles Associated with Autism Spectrum Disorder: A Case–Control Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hickman, Allison R.
      – PersonEntity:
          Name:
            NameFull: Selee, Bradley
      – PersonEntity:
          Name:
            NameFull: Pauly, Rini
      – PersonEntity:
          Name:
            NameFull: Husain, Benafsh
      – PersonEntity:
          Name:
            NameFull: Hang, Yuqing
      – PersonEntity:
          Name:
            NameFull: Feltus, Frank Alex
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2023
              Type: published
              Y: 2023
          Identifiers:
            – Type: issn-print
              Value: 01623257
          Numbering:
            – Type: volume
              Value: 53
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Journal of Autism & Developmental Disorders
              Type: main
ResultId 1