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Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: an explorative analysis on symptom dimensions.

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Title: Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: an explorative analysis on symptom dimensions.
Authors: Tuncturk, Mustafa, Ermis, Cagatay, Buyuktaskin, Dicle, Turan, Serkan, Saglam, Yesim, Alarslan, Sezen, Guler, Duru, Sut, Ekin, Unutmaz, Guldal, Guzel, Ayse Beste, Atay Canbek, Ozge, Inal, Neslihan, Karacetin, Gul, Hazell, Philip
Source: International Journal of Psychiatry in Clinical Practice. Sep2023, Vol. 27 Issue 3, p257-263. 7p.
Subjects: Schizophrenia treatment, Academic medical centers, Affect (Psychology), Schizophrenia, Electroconvulsive therapy, Retrospective studies, Acquisition of data, Treatment effectiveness, Comparative studies, Severity of illness index, Clozapine, Medical records, Aggression (Psychology), Smoking, Adolescence
Abstract: This study sought to compare pre-intervention patient characteristics and post-intervention outcomes in a naturalistic sample of adolescent inpatients with treatment-resistant psychotic symptoms who received either electroconvulsive therapy (ECT) or clozapine. Data of adolescents with schizophrenia/schizoaffective disorder receiving ECT or clozapine were retrospectively collected from two tertiary-care psychiatry-teaching university hospitals. Subscale scores of the Positive and Negative Symptom Scale (PANSS) factors were calculated according to the five-factor solution. Baseline demographics, illness characteristics, and post-intervention outcomes were compared. There was no significant difference between patients receiving ECT (n = 13) and clozapine (n = 66) in terms of age, sex, and the duration of hospital stay. The ECT group more commonly had higher overall illness and aggression severity. Smoking was less frequent in the clozapine group. Baseline resistance/excitement symptom severity was significantly higher in the ECT group, while positive, negative, affect, disorganisation, and total symptom scores were not. Both interventions provided a significant reduction in PANSS scores with large effect sizes. Both ECT and clozapine yielded high effectiveness rates in adolescents with treatment-resistant schizophrenia/schizoaffective disorder. Youth receiving ECT were generally more activated than those who received clozapine. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: an explorative analysis on symptom dimensions.
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  Data: <searchLink fieldCode="AR" term="%22Tuncturk%2C+Mustafa%22">Tuncturk, Mustafa</searchLink><br /><searchLink fieldCode="AR" term="%22Ermis%2C+Cagatay%22">Ermis, Cagatay</searchLink><br /><searchLink fieldCode="AR" term="%22Buyuktaskin%2C+Dicle%22">Buyuktaskin, Dicle</searchLink><br /><searchLink fieldCode="AR" term="%22Turan%2C+Serkan%22">Turan, Serkan</searchLink><br /><searchLink fieldCode="AR" term="%22Saglam%2C+Yesim%22">Saglam, Yesim</searchLink><br /><searchLink fieldCode="AR" term="%22Alarslan%2C+Sezen%22">Alarslan, Sezen</searchLink><br /><searchLink fieldCode="AR" term="%22Guler%2C+Duru%22">Guler, Duru</searchLink><br /><searchLink fieldCode="AR" term="%22Sut%2C+Ekin%22">Sut, Ekin</searchLink><br /><searchLink fieldCode="AR" term="%22Unutmaz%2C+Guldal%22">Unutmaz, Guldal</searchLink><br /><searchLink fieldCode="AR" term="%22Guzel%2C+Ayse+Beste%22">Guzel, Ayse Beste</searchLink><br /><searchLink fieldCode="AR" term="%22Atay+Canbek%2C+Ozge%22">Atay Canbek, Ozge</searchLink><br /><searchLink fieldCode="AR" term="%22Inal%2C+Neslihan%22">Inal, Neslihan</searchLink><br /><searchLink fieldCode="AR" term="%22Karacetin%2C+Gul%22">Karacetin, Gul</searchLink><br /><searchLink fieldCode="AR" term="%22Hazell%2C+Philip%22">Hazell, Philip</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Psychiatry+in+Clinical+Practice%22">International Journal of Psychiatry in Clinical Practice</searchLink>. Sep2023, Vol. 27 Issue 3, p257-263. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia+treatment%22">Schizophrenia treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Affect+%28Psychology%29%22">Affect (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Electroconvulsive+therapy%22">Electroconvulsive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data%22">Acquisition of data</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Clozapine%22">Clozapine</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Aggression+%28Psychology%29%22">Aggression (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: This study sought to compare pre-intervention patient characteristics and post-intervention outcomes in a naturalistic sample of adolescent inpatients with treatment-resistant psychotic symptoms who received either electroconvulsive therapy (ECT) or clozapine. Data of adolescents with schizophrenia/schizoaffective disorder receiving ECT or clozapine were retrospectively collected from two tertiary-care psychiatry-teaching university hospitals. Subscale scores of the Positive and Negative Symptom Scale (PANSS) factors were calculated according to the five-factor solution. Baseline demographics, illness characteristics, and post-intervention outcomes were compared. There was no significant difference between patients receiving ECT (n = 13) and clozapine (n = 66) in terms of age, sex, and the duration of hospital stay. The ECT group more commonly had higher overall illness and aggression severity. Smoking was less frequent in the clozapine group. Baseline resistance/excitement symptom severity was significantly higher in the ECT group, while positive, negative, affect, disorganisation, and total symptom scores were not. Both interventions provided a significant reduction in PANSS scores with large effect sizes. Both ECT and clozapine yielded high effectiveness rates in adolescents with treatment-resistant schizophrenia/schizoaffective disorder. Youth receiving ECT were generally more activated than those who received clozapine. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=171338629
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/13651501.2022.2160764
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 257
    Subjects:
      – SubjectFull: Schizophrenia treatment
        Type: general
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Affect (Psychology)
        Type: general
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Electroconvulsive therapy
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Acquisition of data
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Comparative studies
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      – SubjectFull: Severity of illness index
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      – SubjectFull: Clozapine
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      – SubjectFull: Medical records
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      – SubjectFull: Aggression (Psychology)
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      – SubjectFull: Smoking
        Type: general
      – SubjectFull: Adolescence
        Type: general
    Titles:
      – TitleFull: Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: an explorative analysis on symptom dimensions.
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              Text: Sep2023
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