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Increased elasticity of sucrose demand during hyperdopaminergic states in rats.

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Title: Increased elasticity of sucrose demand during hyperdopaminergic states in rats.
Authors: Minnaard, A. Maryse (AUTHOR), Luijendijk, Mieneke C. M. (AUTHOR), Baars, Annemarie M. (AUTHOR), Drost, Lisa (AUTHOR), Ramakers, Geert M. J. (AUTHOR), Adan, Roger A. H. (AUTHOR), Lesscher, Heidi M. B. (AUTHOR), Vanderschuren, Louk J. M. J. (AUTHOR)
Source: Psychopharmacology. Mar2022, Vol. 239 Issue 3, p773-794. 22p.
Subjects: Dopamine, Elasticity (Economics), Dopaminergic neurons, Incentive (Psychology), Reinforcement (Psychology), Dopamine receptors
Abstract: Rationale: Deficits in cost–benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been implicated in various processes related to cognition and reward, but its precise role in reward valuation and cost–benefit trade-off decisions remains incompletely understood. Objectives: We assessed the role of mesocorticolimbic dopamine signalling in the relationship between price and consumption of sucrose, to better understand its role in cost–benefit decisions. Methods: Dopamine neurons in the ventral tegmental area (VTA) were chemogenetically activated in rats, and a behavioural economics approach was used to quantify the relationship between price and consumption of sucrose. Motivation for sucrose was also assessed under a progressive ratio (PR) schedule of reinforcement. To further gauge the role of dopamine in cost–benefit trade-offs for sucrose, the effects of treatment with D-amphetamine and the dopamine receptor antagonist alpha-flupentixol were assessed. Results: Chemogenetic activation of VTA dopamine neurons increased demand elasticity, while responding for sucrose under a PR schedule of reinforcement was augmented upon stimulation of VTA dopamine neurons. Treatment with amphetamine partially replicated the effects of chemogenetic dopamine neuron activation, whereas treatment with alpha-flupentixol reduced free consumption of sucrose and had mixed effects on demand elasticity. Conclusions: Stimulation of mesocorticolimbic dopaminergic neurotransmission altered cost–benefit trade-offs in a complex manner. It reduced the essential value of palatable food, increased incentive motivation and left free consumption unaltered. Together, these findings imply that mesocorticolimbic dopamine signalling differentially influences distinct components of cost expenditure processes aimed at obtaining rewards. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: <searchLink fieldCode="AR" term="%22Minnaard%2C+A%2E+Maryse%22">Minnaard, A. Maryse</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luijendijk%2C+Mieneke+C%2E+M%2E%22">Luijendijk, Mieneke C. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baars%2C+Annemarie+M%2E%22">Baars, Annemarie M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Drost%2C+Lisa%22">Drost, Lisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramakers%2C+Geert+M%2E+J%2E%22">Ramakers, Geert M. J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adan%2C+Roger+A%2E+H%2E%22">Adan, Roger A. H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lesscher%2C+Heidi+M%2E+B%2E%22">Lesscher, Heidi M. B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vanderschuren%2C+Louk+J%2E+M%2E+J%2E%22">Vanderschuren, Louk J. M. J.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Mar2022, Vol. 239 Issue 3, p773-794. 22p.
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  Data: <searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Elasticity+%28Economics%29%22">Elasticity (Economics)</searchLink><br /><searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Incentive+%28Psychology%29%22">Incentive (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Reinforcement+%28Psychology%29%22">Reinforcement (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink>
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  Data: Rationale: Deficits in cost–benefit decision-making are a core feature of several psychiatric disorders, including substance addiction, eating disorders and bipolar disorder. Mesocorticolimbic dopamine signalling has been implicated in various processes related to cognition and reward, but its precise role in reward valuation and cost–benefit trade-off decisions remains incompletely understood. Objectives: We assessed the role of mesocorticolimbic dopamine signalling in the relationship between price and consumption of sucrose, to better understand its role in cost–benefit decisions. Methods: Dopamine neurons in the ventral tegmental area (VTA) were chemogenetically activated in rats, and a behavioural economics approach was used to quantify the relationship between price and consumption of sucrose. Motivation for sucrose was also assessed under a progressive ratio (PR) schedule of reinforcement. To further gauge the role of dopamine in cost–benefit trade-offs for sucrose, the effects of treatment with D-amphetamine and the dopamine receptor antagonist alpha-flupentixol were assessed. Results: Chemogenetic activation of VTA dopamine neurons increased demand elasticity, while responding for sucrose under a PR schedule of reinforcement was augmented upon stimulation of VTA dopamine neurons. Treatment with amphetamine partially replicated the effects of chemogenetic dopamine neuron activation, whereas treatment with alpha-flupentixol reduced free consumption of sucrose and had mixed effects on demand elasticity. Conclusions: Stimulation of mesocorticolimbic dopaminergic neurotransmission altered cost–benefit trade-offs in a complex manner. It reduced the essential value of palatable food, increased incentive motivation and left free consumption unaltered. Together, these findings imply that mesocorticolimbic dopamine signalling differentially influences distinct components of cost expenditure processes aimed at obtaining rewards. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Mar2022
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