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Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence.

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Title: Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence.
Authors: Kim, Baeksun (AUTHOR), Tag, Sung Hyun (AUTHOR), Kim, Yong Sik (AUTHOR), Cho, Sung Nam (AUTHOR), Im, Heh-In (AUTHOR)
Source: Psychopharmacology. Mar2022, Vol. 239 Issue 3, p831-840. 10p.
Subjects: Methamphetamine, MicroRNA, Extracellular vesicles, Smoking, Mental depression, Biomarkers, Vesicles (Cytology)
Geographic Terms: Seoul (Korea)
Abstract: Objective: Stimulant use instigates abstinence syndrome in humans. miRNAs are a critical component for the pathophysiology of stimulant abstinence. Here we sought to identify a miRNA marker of methamphetamine abstinence in the circulating extracellular vesicles (cEVs). Methods: miR-137 in the cEVs was quantified by qPCR in thirty-seven patients under methamphetamine abstinence and thirty-five age-matched healthy controls recruited from 2014 to 2016 from the general adult population in a hospital setting, Seoul, South Korea. Diagnostic power was evaluated by area under curve in the receiver-operating characteristics curve and other multiple statistical parameters. Results: Patients under methamphetamine abstinence exhibited a significant reduction in cEV miR-137. Overall, cEV miR-137 had high potential as a blood-based marker of methamphetamine abstinence. cEV miR-137 retained the diagnostic power irrespective of the duration of methamphetamine abstinence or methamphetamine use. Interestingly, cEV miR-137 interacted with age: Control participants displayed an aging-dependent reduction of cEV miR-137, while methamphetamine-abstinent patients showed an aging-dependent increase in cEV miR-137. Accordingly, cEV miR-137 had variable diagnostic power depending on age, in which cEV miR-137 more effectively discriminated methamphetamine abstinence in the younger population. Duration of methamphetamine use or abstinence, cigarette smoking status, depressive disorder, or antidepressant treatment did not interact with the methamphetamine abstinence-induced reduction of cEV miR-137. Conclusion: Our data collectively demonstrated that miR-137 in the circulating extracellular vesicles held high potential as a stable and accurate diagnostic marker of methamphetamine abstinence syndrome. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Circulating microRNA miR-137 as a stable biomarker for methamphetamine abstinence.
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Baeksun%22">Kim, Baeksun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tag%2C+Sung+Hyun%22">Tag, Sung Hyun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Yong+Sik%22">Kim, Yong Sik</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cho%2C+Sung+Nam%22">Cho, Sung Nam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Im%2C+Heh-In%22">Im, Heh-In</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Mar2022, Vol. 239 Issue 3, p831-840. 10p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Methamphetamine%22">Methamphetamine</searchLink><br /><searchLink fieldCode="DE" term="%22MicroRNA%22">MicroRNA</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+vesicles%22">Extracellular vesicles</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Vesicles+%28Cytology%29%22">Vesicles (Cytology)</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Seoul+%28Korea%29%22">Seoul (Korea)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Stimulant use instigates abstinence syndrome in humans. miRNAs are a critical component for the pathophysiology of stimulant abstinence. Here we sought to identify a miRNA marker of methamphetamine abstinence in the circulating extracellular vesicles (cEVs). Methods: miR-137 in the cEVs was quantified by qPCR in thirty-seven patients under methamphetamine abstinence and thirty-five age-matched healthy controls recruited from 2014 to 2016 from the general adult population in a hospital setting, Seoul, South Korea. Diagnostic power was evaluated by area under curve in the receiver-operating characteristics curve and other multiple statistical parameters. Results: Patients under methamphetamine abstinence exhibited a significant reduction in cEV miR-137. Overall, cEV miR-137 had high potential as a blood-based marker of methamphetamine abstinence. cEV miR-137 retained the diagnostic power irrespective of the duration of methamphetamine abstinence or methamphetamine use. Interestingly, cEV miR-137 interacted with age: Control participants displayed an aging-dependent reduction of cEV miR-137, while methamphetamine-abstinent patients showed an aging-dependent increase in cEV miR-137. Accordingly, cEV miR-137 had variable diagnostic power depending on age, in which cEV miR-137 more effectively discriminated methamphetamine abstinence in the younger population. Duration of methamphetamine use or abstinence, cigarette smoking status, depressive disorder, or antidepressant treatment did not interact with the methamphetamine abstinence-induced reduction of cEV miR-137. Conclusion: Our data collectively demonstrated that miR-137 in the circulating extracellular vesicles held high potential as a stable and accurate diagnostic marker of methamphetamine abstinence syndrome. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00213-022-06074-z
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      – SubjectFull: Methamphetamine
        Type: general
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      – SubjectFull: Extracellular vesicles
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      – SubjectFull: Seoul (Korea)
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              Text: Mar2022
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