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Vitamin D deficiency and genetic polymorphisms of vitamin D‐associated genes in Parkinson's disease.

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Title: Vitamin D deficiency and genetic polymorphisms of vitamin D‐associated genes in Parkinson's disease.
Authors: Pal, Randrita (AUTHOR), Choudhury, Supriyo (AUTHOR), Kumar, Hrishikesh (AUTHOR), Dey, Sanjit (AUTHOR), Das, Nilansu (AUTHOR), Basu, Barnali Ray (AUTHOR)
Source: European Journal of Neuroscience. Sep2023, Vol. 58 Issue 5, p3362-3377. 16p. 3 Diagrams, 4 Charts.
Subjects: Vitamin D deficiency, Parkinson's disease, Genetic polymorphisms, Vitamin D receptors, Vitamin D, Single nucleotide polymorphisms
Abstract: Parkinson's disease (PD) and vitamin D share a unique link as vitamin D deficiency (VDD) prevails in PD. Thus, an in‐depth understanding of vitamin D biology in PD might be crucial for therapeutic strategies emphasising vitamin D. Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D‐associated genes in PD, like VDR (vitamin D receptor) or GC (vitamin D binding protein) may aid the process along with polymorphisms of vitamin D metabolising genes (e.g., CYP2R1 and CYP27A1) in PD. Literature review of single nucleotide polymorphisms (SNPs) related to vitamin D levels [GC (GC1‐rs7041 and GC2‐rs4588), CYP2R1, CYP24A1 and CYP27B1] and vitamin D function [VDR (FokI ‐ rs2228570 and rs10735810; ApaI ‐ rs7976091, rs7975232BsmI and rs1544410; and TaqI ‐ rs731236)] was conducted to explore their relationship with PD severity globally. VDR‐FokI polymorphism was reported to be significantly associated with PD in Hungarian, Chinese and Japanese populations, whereas VDR‐ApaI polymorphism was found to affect PD in the Iranian population. However, VDR‐TaqI and BsmI polymorphisms had no significant association with PD severity. Conversely, GC1 polymorphisms reportedly affected vitamin D levels without influencing the disease severity. CYP2R1 (excluding rs1993116) was also reportedly linked to clinical manifestations of PD. Genetic polymorphisms might cause VDD despite enough sunlight exposure and vitamin D‐rich food intake, enhancing inflammation, there by influencing PD pathophysiology. Knowledge of the polymorphisms associated with VDD appears promising for developing precision vitamin D‐dosing therapeutic strategies against PD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Vitamin D deficiency and genetic polymorphisms of vitamin D‐associated genes in Parkinson's disease.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Pal%2C+Randrita%22">Pal, Randrita</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choudhury%2C+Supriyo%22">Choudhury, Supriyo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumar%2C+Hrishikesh%22">Kumar, Hrishikesh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dey%2C+Sanjit%22">Dey, Sanjit</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Das%2C+Nilansu%22">Das, Nilansu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Basu%2C+Barnali+Ray%22">Basu, Barnali Ray</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2023, Vol. 58 Issue 5, p3362-3377. 16p. 3 Diagrams, 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Vitamin+D+deficiency%22">Vitamin D deficiency</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+D+receptors%22">Vitamin D receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+D%22">Vitamin D</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Parkinson's disease (PD) and vitamin D share a unique link as vitamin D deficiency (VDD) prevails in PD. Thus, an in‐depth understanding of vitamin D biology in PD might be crucial for therapeutic strategies emphasising vitamin D. Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D‐associated genes in PD, like VDR (vitamin D receptor) or GC (vitamin D binding protein) may aid the process along with polymorphisms of vitamin D metabolising genes (e.g., CYP2R1 and CYP27A1) in PD. Literature review of single nucleotide polymorphisms (SNPs) related to vitamin D levels [GC (GC1‐rs7041 and GC2‐rs4588), CYP2R1, CYP24A1 and CYP27B1] and vitamin D function [VDR (FokI ‐ rs2228570 and rs10735810; ApaI ‐ rs7976091, rs7975232BsmI and rs1544410; and TaqI ‐ rs731236)] was conducted to explore their relationship with PD severity globally. VDR‐FokI polymorphism was reported to be significantly associated with PD in Hungarian, Chinese and Japanese populations, whereas VDR‐ApaI polymorphism was found to affect PD in the Iranian population. However, VDR‐TaqI and BsmI polymorphisms had no significant association with PD severity. Conversely, GC1 polymorphisms reportedly affected vitamin D levels without influencing the disease severity. CYP2R1 (excluding rs1993116) was also reportedly linked to clinical manifestations of PD. Genetic polymorphisms might cause VDD despite enough sunlight exposure and vitamin D‐rich food intake, enhancing inflammation, there by influencing PD pathophysiology. Knowledge of the polymorphisms associated with VDD appears promising for developing precision vitamin D‐dosing therapeutic strategies against PD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=171369380
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      – Type: doi
        Value: 10.1111/ejn.16098
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 3362
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      – SubjectFull: Vitamin D deficiency
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Genetic polymorphisms
        Type: general
      – SubjectFull: Vitamin D receptors
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      – SubjectFull: Vitamin D
        Type: general
      – SubjectFull: Single nucleotide polymorphisms
        Type: general
    Titles:
      – TitleFull: Vitamin D deficiency and genetic polymorphisms of vitamin D‐associated genes in Parkinson's disease.
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            NameFull: Pal, Randrita
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            NameFull: Choudhury, Supriyo
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            NameFull: Kumar, Hrishikesh
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            NameFull: Das, Nilansu
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            – D: 01
              M: 09
              Text: Sep2023
              Type: published
              Y: 2023
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