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Health-related quality of life among people who inject drugs in Australia.

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Title: Health-related quality of life among people who inject drugs in Australia.
Authors: Cheng, Qinglu (AUTHOR), Bajis, Sahar (AUTHOR), Cunningham, Evan (AUTHOR), Shih, Sophy T. F. (AUTHOR), Schulz, Marcel (AUTHOR), Marshall, Alison D. (AUTHOR), Martin, Natasha K. (AUTHOR), Miners, Alec (AUTHOR), Hajarizadeh, Behzad (AUTHOR), Wiseman, Virginia (AUTHOR), Dore, Gregory J. (AUTHOR), Grebely, Jason (AUTHOR)
Source: Quality of Life Research. Nov2023, Vol. 32 Issue 11, p3195-3207. 13p. 7 Charts, 2 Graphs.
Subjects: Quality of life, Hepatic fibrosis, Drug abuse, Alcohol drinking, Liver diseases
Geographic Terms: Australia
Abstract: Purpose: There is limited research on health-related quality of life (HRQoL) among people who inject drugs (PWID). We aimed to evaluate factors associated with HRQoL among a cohort of PWID in Australia. Methods: Participants were enrolled in an observational cohort study (the LiveRLife Study) between 2014 and 2018 at 15 sites in Australia. They provided fingerstick whole-blood samples for point-of-care HCV RNA testing and underwent transient elastography to assess liver disease. Participants completed the EQ-5D-3L survey at enrolment. Regression models were used to assess the impact of clinical and socioeconomic characteristics on the EQ-5D-3L scores. Results: Among 751 participants (median age, 43 years; 67% male), 63% reported injection drug use in the past month, 43% had current HCV infection, and 68% had no/mild liver fibrosis (F0/F1). The mean EQ-5D-3L and EQ-VAS scores were 0.67 and 62, respectively, for the overall study population. There was no significant difference in the EQ-5D-3L scores among people with and without recent injecting drug use (mean: 0.66 vs. 0.68, median: 0.73 vs. 0.78, P = 0.405), and among people receiving and not receiving opioid agonist therapy (mean: 0.66 vs. 0.68, median: 0.73 vs. 0.76, P = 0.215). Participants who were employed were found to have the highest mean EQ-5D-3L (0.83) and EQ-VAS scores (77). The presence of current HCV infection, liver fibrosis stage, and high-risk alcohol consumption had little impact on HRQoL. Conclusions: The study findings provide important HRQoL data for economic evaluations, useful for guiding the allocation of resources for HCV elimination strategies and interventions among PWID. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Health-related quality of life among people who inject drugs in Australia.
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  Data: <searchLink fieldCode="AR" term="%22Cheng%2C+Qinglu%22">Cheng, Qinglu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bajis%2C+Sahar%22">Bajis, Sahar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cunningham%2C+Evan%22">Cunningham, Evan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shih%2C+Sophy+T%2E+F%2E%22">Shih, Sophy T. F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schulz%2C+Marcel%22">Schulz, Marcel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marshall%2C+Alison+D%2E%22">Marshall, Alison D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martin%2C+Natasha+K%2E%22">Martin, Natasha K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miners%2C+Alec%22">Miners, Alec</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hajarizadeh%2C+Behzad%22">Hajarizadeh, Behzad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiseman%2C+Virginia%22">Wiseman, Virginia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dore%2C+Gregory+J%2E%22">Dore, Gregory J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grebely%2C+Jason%22">Grebely, Jason</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Nov2023, Vol. 32 Issue 11, p3195-3207. 13p. 7 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatic+fibrosis%22">Hepatic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse%22">Drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+diseases%22">Liver diseases</searchLink>
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  Data: Purpose: There is limited research on health-related quality of life (HRQoL) among people who inject drugs (PWID). We aimed to evaluate factors associated with HRQoL among a cohort of PWID in Australia. Methods: Participants were enrolled in an observational cohort study (the LiveRLife Study) between 2014 and 2018 at 15 sites in Australia. They provided fingerstick whole-blood samples for point-of-care HCV RNA testing and underwent transient elastography to assess liver disease. Participants completed the EQ-5D-3L survey at enrolment. Regression models were used to assess the impact of clinical and socioeconomic characteristics on the EQ-5D-3L scores. Results: Among 751 participants (median age, 43 years; 67% male), 63% reported injection drug use in the past month, 43% had current HCV infection, and 68% had no/mild liver fibrosis (F0/F1). The mean EQ-5D-3L and EQ-VAS scores were 0.67 and 62, respectively, for the overall study population. There was no significant difference in the EQ-5D-3L scores among people with and without recent injecting drug use (mean: 0.66 vs. 0.68, median: 0.73 vs. 0.78, P = 0.405), and among people receiving and not receiving opioid agonist therapy (mean: 0.66 vs. 0.68, median: 0.73 vs. 0.76, P = 0.215). Participants who were employed were found to have the highest mean EQ-5D-3L (0.83) and EQ-VAS scores (77). The presence of current HCV infection, liver fibrosis stage, and high-risk alcohol consumption had little impact on HRQoL. Conclusions: The study findings provide important HRQoL data for economic evaluations, useful for guiding the allocation of resources for HCV elimination strategies and interventions among PWID. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s11136-023-03465-3
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