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Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.

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Title: Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.
Authors: Ly, Annie (AUTHOR), Barker, Alexandra (AUTHOR), Hotchkiss, Hayden (AUTHOR), Prévost, Emily D. (AUTHOR), McGovern, Dillon J. (AUTHOR), Kilpatrick, Zachary (AUTHOR), Root, David H. (AUTHOR)
Source: European Journal of Neuroscience. Oct2023, Vol. 58 Issue 7, p3630-3649. 20p. 1 Color Photograph, 1 Diagram, 1 Chart, 5 Graphs.
Subjects: GABA, Neurons, Nests, Rumen (Ruminants), Units of time, Predation
Abstract: Foraging is a universal behaviour that has co‐evolved with predation pressure. We investigated the role of the bed nucleus of the stria terminalis (BNST) GABA neurons in robotic and live predator threat processing and their consequences in post‐threat encounter foraging. Both robotic and live predator interactions increased BNST GABA neuron activity. Mice were trained to procure food in a laboratory‐based foraging apparatus in which food pellets were placed at incrementally greater distances from a nest zone. After mice learned to forage, they were exposed to a robotic or live predator threat, while BNST GABA neurons were chemogenetically inhibited. Post‐robotic threat encounter, mice spent more time in the nest zone, but other foraging parameters were unchanged compared with pre‐encounter behaviour. Inhibition of BNST GABA neurons had no effect on foraging behaviour post‐robotic threat encounter. Following live predator exposure, control mice spent significantly more time in the nest zone, increased their latency to successfully forage, and significantly altered their overall foraging performance. Inhibition of BNST GABA neurons during live predator exposure prevented changes in foraging behaviour from developing after a live predator threat. BNST GABA neuron inhibition did not alter foraging behaviour during robotic or live predator threats. We conclude that these results demonstrate that while both robotic and live predator encounters effectively intrude on foraging behaviour, the perceived risk and behavioural consequences of the threat are distinguishable. Additionally, BNST GABA neurons may play a role in the integration of prior innate predator threat experience that results in hypervigilance during post‐encounter foraging behaviour. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.
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  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ly%2C+Annie%22">Ly, Annie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barker%2C+Alexandra%22">Barker, Alexandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hotchkiss%2C+Hayden%22">Hotchkiss, Hayden</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prévost%2C+Emily+D%2E%22">Prévost, Emily D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McGovern%2C+Dillon+J%2E%22">McGovern, Dillon J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kilpatrick%2C+Zachary%22">Kilpatrick, Zachary</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Root%2C+David+H%2E%22">Root, David H.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2023, Vol. 58 Issue 7, p3630-3649. 20p. 1 Color Photograph, 1 Diagram, 1 Chart, 5 Graphs.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22GABA%22">GABA</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Nests%22">Nests</searchLink><br /><searchLink fieldCode="DE" term="%22Rumen+%28Ruminants%29%22">Rumen (Ruminants)</searchLink><br /><searchLink fieldCode="DE" term="%22Units+of+time%22">Units of time</searchLink><br /><searchLink fieldCode="DE" term="%22Predation%22">Predation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Foraging is a universal behaviour that has co‐evolved with predation pressure. We investigated the role of the bed nucleus of the stria terminalis (BNST) GABA neurons in robotic and live predator threat processing and their consequences in post‐threat encounter foraging. Both robotic and live predator interactions increased BNST GABA neuron activity. Mice were trained to procure food in a laboratory‐based foraging apparatus in which food pellets were placed at incrementally greater distances from a nest zone. After mice learned to forage, they were exposed to a robotic or live predator threat, while BNST GABA neurons were chemogenetically inhibited. Post‐robotic threat encounter, mice spent more time in the nest zone, but other foraging parameters were unchanged compared with pre‐encounter behaviour. Inhibition of BNST GABA neurons had no effect on foraging behaviour post‐robotic threat encounter. Following live predator exposure, control mice spent significantly more time in the nest zone, increased their latency to successfully forage, and significantly altered their overall foraging performance. Inhibition of BNST GABA neurons during live predator exposure prevented changes in foraging behaviour from developing after a live predator threat. BNST GABA neuron inhibition did not alter foraging behaviour during robotic or live predator threats. We conclude that these results demonstrate that while both robotic and live predator encounters effectively intrude on foraging behaviour, the perceived risk and behavioural consequences of the threat are distinguishable. Additionally, BNST GABA neurons may play a role in the integration of prior innate predator threat experience that results in hypervigilance during post‐encounter foraging behaviour. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1111/ejn.16137
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      – Code: eng
        Text: English
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        StartPage: 3630
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        Type: general
      – SubjectFull: Neurons
        Type: general
      – SubjectFull: Nests
        Type: general
      – SubjectFull: Rumen (Ruminants)
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      – SubjectFull: Units of time
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      – SubjectFull: Predation
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    Titles:
      – TitleFull: Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.
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            NameFull: Ly, Annie
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            NameFull: Barker, Alexandra
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            NameFull: Hotchkiss, Hayden
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            NameFull: Prévost, Emily D.
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            NameFull: McGovern, Dillon J.
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            NameFull: Root, David H.
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            – D: 01
              M: 10
              Text: Oct2023
              Type: published
              Y: 2023
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              Value: 58
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