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Inclusion body myositis. Genetics, biomarkers and muscle biopsy.

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Title: Inclusion body myositis. Genetics, biomarkers and muscle biopsy.
Authors: Mavroudis, Ioannis (AUTHOR), Petridis, Foivos (AUTHOR), Kazis, Dimitrios (AUTHOR)
Source: International Journal of Neuroscience. Dec2023, Vol. 133 Issue 11, p1211-1217. 7p.
Subjects: Inclusion body myositis, Myositis, Genetics, Biomarkers, Therapeutics, Stair climbing
Abstract: Sporadic inclusion body myositis is the most common idiopathic inflammatory myopathy over the age of 50, with a male-to-female ratio of 3:1. Symptoms onset before age of 60 occurs in 18-20% of patients, with a delay in diagnosis of 5 to 8 years. The classic clinical presentation of SIBM consists of proximal leg and distal arm weakness, and most commonly patients present early slowly progressive quadriceps weakness which leads to falls and to difficulties in climbing stairs, while less common the initial complaints refer to finger flexor weakness and atrophy, foot drop, or dysphagia, and rare presentations include prominent forearm weakness, sparing the quadriceps. The aetiopathogenesis of the disease remains unclear and despite some preliminary promising results, to the day there is no effective treatment. The diagnosis of SIBM is based on the clinical presentation and the histopathological findings in muscle biopsy, however increasing evidence on genetics and paraclinical biomarkers has recently come to light giving new insights on the pathogenesis, the diagnosis and the potential treatment of the disease. In the present study we aim to review the histopathological findings, genetics and blood biomarkers, and to review the role of muscle biopsy in the diagnosis of SIBM. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Inclusion body myositis. Genetics, biomarkers and muscle biopsy.
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  Data: <searchLink fieldCode="AR" term="%22Mavroudis%2C+Ioannis%22">Mavroudis, Ioannis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Petridis%2C+Foivos%22">Petridis, Foivos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kazis%2C+Dimitrios%22">Kazis, Dimitrios</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec2023, Vol. 133 Issue 11, p1211-1217. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Inclusion+body+myositis%22">Inclusion body myositis</searchLink><br /><searchLink fieldCode="DE" term="%22Myositis%22">Myositis</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Stair+climbing%22">Stair climbing</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Sporadic inclusion body myositis is the most common idiopathic inflammatory myopathy over the age of 50, with a male-to-female ratio of 3:1. Symptoms onset before age of 60 occurs in 18-20% of patients, with a delay in diagnosis of 5 to 8 years. The classic clinical presentation of SIBM consists of proximal leg and distal arm weakness, and most commonly patients present early slowly progressive quadriceps weakness which leads to falls and to difficulties in climbing stairs, while less common the initial complaints refer to finger flexor weakness and atrophy, foot drop, or dysphagia, and rare presentations include prominent forearm weakness, sparing the quadriceps. The aetiopathogenesis of the disease remains unclear and despite some preliminary promising results, to the day there is no effective treatment. The diagnosis of SIBM is based on the clinical presentation and the histopathological findings in muscle biopsy, however increasing evidence on genetics and paraclinical biomarkers has recently come to light giving new insights on the pathogenesis, the diagnosis and the potential treatment of the disease. In the present study we aim to review the histopathological findings, genetics and blood biomarkers, and to review the role of muscle biopsy in the diagnosis of SIBM. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/00207454.2020.1763340
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 1211
    Subjects:
      – SubjectFull: Inclusion body myositis
        Type: general
      – SubjectFull: Myositis
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Stair climbing
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      – TitleFull: Inclusion body myositis. Genetics, biomarkers and muscle biopsy.
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            NameFull: Petridis, Foivos
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            NameFull: Kazis, Dimitrios
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            – D: 01
              M: 12
              Text: Dec2023
              Type: published
              Y: 2023
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