Neuropsychological markers of antidepressant action: a secondary analysis of the ANTLER randomised controlled trial.
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| Title: | Neuropsychological markers of antidepressant action: a secondary analysis of the ANTLER randomised controlled trial. |
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| Authors: | Rodriguez-Sanchez, Julia (AUTHOR), Lewis, Gemma (AUTHOR), Solmi, Francesca (AUTHOR), Bone, Jessica K. (AUTHOR), Moore, Michael (AUTHOR), Wiles, Nicola (AUTHOR), Harmer, Catherine J. (AUTHOR), Duffy, Larisa (AUTHOR), Lewis, Glyn (AUTHOR) |
| Source: | Psychological Medicine. Oct2023, Vol. 53 Issue 14, p6592-6599. 8p. |
| Subjects: | Antidepressants, Confidence intervals, Self-perception, Disease relapse, Risk assessment, Research funding, Emotions, Disease risk factors |
| Abstract: | Background: Antidepressants have been proposed to act via their influence on emotional processing. We investigated the effect of discontinuing maintenance antidepressant treatment on positive and negative self-referential recall and the association between self-referential recall and risk of relapse. Methods: The ANTLER trial was a large (N = 478) pragmatic double-blind trial investigating the clinical effectiveness of long-term antidepressant treatment for preventing relapse in primary care patients. Participants were randomised to continue their maintenance antidepressants or discontinue via a taper to placebo. We analysed memory for positive and negative personality descriptors, assessed at baseline, 12- and 52-week follow-up. Results: The recall task was completed by 437 participants. There was no evidence of an effect of discontinuation on self-referential recall at 12 [positive recall ratio 1.00, 95% CI (0.90–1.11), p = 0.93; negative recall ratio 1.00 (0.87–1.14), p = 0.87] or 52 weeks [positive recall ratio 1.03 (0.91–1.17), p = 0.62; negative recall ratio 1.00 (0.86–1.15), p = 0.96; ratios larger than one indicate higher recall in the discontinuation group], and no evidence of an association between recall at baseline or 12 weeks and later relapse [baseline, positive hazard ratio (HR) 1.02 (0.93–1.12), p = 0.74; negative HR 1.01 (0.90–1.13), p = 0.87; 12 weeks, positive HR 0.99 (0.89–1.09), p = 0.81; negative HR 0.98 (0.84–1.14), p = 0.78; ratios larger than one indicate a higher frequency of relapse in those with higher recall]. Conclusions: We found no evidence that discontinuing long-term antidepressants altered self-referential recall or that self-referential recall was associated with risk of relapse. These findings suggest that self-referential recall is not a neuropsychological marker of antidepressant action. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 173276650 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neuropsychological markers of antidepressant action: a secondary analysis of the ANTLER randomised controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rodriguez-Sanchez%2C+Julia%22">Rodriguez-Sanchez, Julia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewis%2C+Gemma%22">Lewis, Gemma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solmi%2C+Francesca%22">Solmi, Francesca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bone%2C+Jessica+K%2E%22">Bone, Jessica K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moore%2C+Michael%22">Moore, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiles%2C+Nicola%22">Wiles, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harmer%2C+Catherine+J%2E%22">Harmer, Catherine J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duffy%2C+Larisa%22">Duffy, Larisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lewis%2C+Glyn%22">Lewis, Glyn</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Oct2023, Vol. 53 Issue 14, p6592-6599. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Self-perception%22">Self-perception</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Emotions%22">Emotions</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Antidepressants have been proposed to act via their influence on emotional processing. We investigated the effect of discontinuing maintenance antidepressant treatment on positive and negative self-referential recall and the association between self-referential recall and risk of relapse. Methods: The ANTLER trial was a large (N = 478) pragmatic double-blind trial investigating the clinical effectiveness of long-term antidepressant treatment for preventing relapse in primary care patients. Participants were randomised to continue their maintenance antidepressants or discontinue via a taper to placebo. We analysed memory for positive and negative personality descriptors, assessed at baseline, 12- and 52-week follow-up. Results: The recall task was completed by 437 participants. There was no evidence of an effect of discontinuation on self-referential recall at 12 [positive recall ratio 1.00, 95% CI (0.90–1.11), p = 0.93; negative recall ratio 1.00 (0.87–1.14), p = 0.87] or 52 weeks [positive recall ratio 1.03 (0.91–1.17), p = 0.62; negative recall ratio 1.00 (0.86–1.15), p = 0.96; ratios larger than one indicate higher recall in the discontinuation group], and no evidence of an association between recall at baseline or 12 weeks and later relapse [baseline, positive hazard ratio (HR) 1.02 (0.93–1.12), p = 0.74; negative HR 1.01 (0.90–1.13), p = 0.87; 12 weeks, positive HR 0.99 (0.89–1.09), p = 0.81; negative HR 0.98 (0.84–1.14), p = 0.78; ratios larger than one indicate a higher frequency of relapse in those with higher recall]. Conclusions: We found no evidence that discontinuing long-term antidepressants altered self-referential recall or that self-referential recall was associated with risk of relapse. These findings suggest that self-referential recall is not a neuropsychological marker of antidepressant action. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/S0033291722003981 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 6592 Subjects: – SubjectFull: Antidepressants Type: general – SubjectFull: Confidence intervals Type: general – SubjectFull: Self-perception Type: general – SubjectFull: Disease relapse Type: general – SubjectFull: Risk assessment Type: general – SubjectFull: Research funding Type: general – SubjectFull: Emotions Type: general – SubjectFull: Disease risk factors Type: general Titles: – TitleFull: Neuropsychological markers of antidepressant action: a secondary analysis of the ANTLER randomised controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rodriguez-Sanchez, Julia – PersonEntity: Name: NameFull: Lewis, Gemma – PersonEntity: Name: NameFull: Solmi, Francesca – PersonEntity: Name: NameFull: Bone, Jessica K. – PersonEntity: Name: NameFull: Moore, Michael – PersonEntity: Name: NameFull: Wiles, Nicola – PersonEntity: Name: NameFull: Harmer, Catherine J. – PersonEntity: Name: NameFull: Duffy, Larisa – PersonEntity: Name: NameFull: Lewis, Glyn IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 10 Text: Oct2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 53 – Type: issue Value: 14 Titles: – TitleFull: Psychological Medicine Type: main |
| ResultId | 1 |
