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Disclosure of HIV status and associated clinical outcomes of children and adolescents living with HIV in Asia.

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Title: Disclosure of HIV status and associated clinical outcomes of children and adolescents living with HIV in Asia.
Authors: Sornillo, Johanna Beulah, Ditangco, Rossana, Lumbiganon, Pagakrong, Vu, Thien An, Le, Oanh Ngoc, Truong, Khanh Huu, Nguyen, Lam Van, Do, Viet Chau, Ounchanum, Pradthana, Wati, Dewi Kumara, Puthanakit, Thanyawee, Kurniati, Nia, Lapphra, Keswadee, Sudjaritruk, Tavitiya, Kumarasamy, Nagalingeswaran, Jamal Mohamed, Thahira A, Nik Yusoff, Nik Khairulddin, Fong, Siew Moy, Nallusamy, Revathy A., Sohn, Annette H.
Source: AIDS Care. Dec2023, Vol. 35 Issue 12, p1928-1937. 10p.
Subjects: Mortality prevention, HIV infection prognosis, HIV infections, Disclosure, Evaluation of medical care, Disease progression, Patient aftercare, Combination drug therapy, Antiretroviral agents, Patient compliance, Psychology of HIV-positive persons, Longitudinal method, Proportional hazards models, Child mortality, Therapeutics, Children, Adolescence
Geographic Terms: Asia
Abstract: Disclosure of HIV status is an important part of pediatric care. We studied disclosure and clinical outcomes in a multi-country Asian cohort of children and adolescents with HIV. Those 6–19 years of age who initiated combination antiretroviral therapy (cART) between 2008 and 2018, and who had at least one follow-up clinic visit were included. Data up to December 2019 were analyzed. Cox and competing risk regression analyses were used to assess the effect of disclosure on disease progression (WHO clinical stage 3 or 4), loss to follow-up (LTFU; > 12 months), and death. Of 1913 children and adolescents (48% female; median [IQR] age 11.5 [9.2–14.7] years at last clinic visit), 795 (42%) were disclosed to about their HIV status at a median age of 12.9 years (IQR: 11.8–14.1). During follow-up, 207 (11%) experienced disease progression, 75 (3.9%) were LTFU, and 59 (3.1%) died. There were lower hazards of disease progression (adjusted hazard ratio [aHR] 0.43 [0.28–0.66]) and death (aHR 0.36 [0.17–0.79]) for those disclosed to compared with those who were not. Disclosure and its appropriate implementation should be promoted in pediatric HIV clinics in resource-limited settings. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Disclosure of HIV status and associated clinical outcomes of children and adolescents living with HIV in Asia.
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  Data: <searchLink fieldCode="AR" term="%22Sornillo%2C+Johanna+Beulah%22">Sornillo, Johanna Beulah</searchLink><br /><searchLink fieldCode="AR" term="%22Ditangco%2C+Rossana%22">Ditangco, Rossana</searchLink><br /><searchLink fieldCode="AR" term="%22Lumbiganon%2C+Pagakrong%22">Lumbiganon, Pagakrong</searchLink><br /><searchLink fieldCode="AR" term="%22Vu%2C+Thien+An%22">Vu, Thien An</searchLink><br /><searchLink fieldCode="AR" term="%22Le%2C+Oanh+Ngoc%22">Le, Oanh Ngoc</searchLink><br /><searchLink fieldCode="AR" term="%22Truong%2C+Khanh+Huu%22">Truong, Khanh Huu</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Lam+Van%22">Nguyen, Lam Van</searchLink><br /><searchLink fieldCode="AR" term="%22Do%2C+Viet+Chau%22">Do, Viet Chau</searchLink><br /><searchLink fieldCode="AR" term="%22Ounchanum%2C+Pradthana%22">Ounchanum, Pradthana</searchLink><br /><searchLink fieldCode="AR" term="%22Wati%2C+Dewi+Kumara%22">Wati, Dewi Kumara</searchLink><br /><searchLink fieldCode="AR" term="%22Puthanakit%2C+Thanyawee%22">Puthanakit, Thanyawee</searchLink><br /><searchLink fieldCode="AR" term="%22Kurniati%2C+Nia%22">Kurniati, Nia</searchLink><br /><searchLink fieldCode="AR" term="%22Lapphra%2C+Keswadee%22">Lapphra, Keswadee</searchLink><br /><searchLink fieldCode="AR" term="%22Sudjaritruk%2C+Tavitiya%22">Sudjaritruk, Tavitiya</searchLink><br /><searchLink fieldCode="AR" term="%22Kumarasamy%2C+Nagalingeswaran%22">Kumarasamy, Nagalingeswaran</searchLink><br /><searchLink fieldCode="AR" term="%22Jamal+Mohamed%2C+Thahira+A%22">Jamal Mohamed, Thahira A</searchLink><br /><searchLink fieldCode="AR" term="%22Nik+Yusoff%2C+Nik+Khairulddin%22">Nik Yusoff, Nik Khairulddin</searchLink><br /><searchLink fieldCode="AR" term="%22Fong%2C+Siew+Moy%22">Fong, Siew Moy</searchLink><br /><searchLink fieldCode="AR" term="%22Nallusamy%2C+Revathy+A%2E%22">Nallusamy, Revathy A.</searchLink><br /><searchLink fieldCode="AR" term="%22Sohn%2C+Annette+H%2E%22">Sohn, Annette H.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Dec2023, Vol. 35 Issue 12, p1928-1937. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Asia%22">Asia</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Disclosure of HIV status is an important part of pediatric care. We studied disclosure and clinical outcomes in a multi-country Asian cohort of children and adolescents with HIV. Those 6–19 years of age who initiated combination antiretroviral therapy (cART) between 2008 and 2018, and who had at least one follow-up clinic visit were included. Data up to December 2019 were analyzed. Cox and competing risk regression analyses were used to assess the effect of disclosure on disease progression (WHO clinical stage 3 or 4), loss to follow-up (LTFU; > 12 months), and death. Of 1913 children and adolescents (48% female; median [IQR] age 11.5 [9.2–14.7] years at last clinic visit), 795 (42%) were disclosed to about their HIV status at a median age of 12.9 years (IQR: 11.8–14.1). During follow-up, 207 (11%) experienced disease progression, 75 (3.9%) were LTFU, and 59 (3.1%) died. There were lower hazards of disease progression (adjusted hazard ratio [aHR] 0.43 [0.28–0.66]) and death (aHR 0.36 [0.17–0.79]) for those disclosed to compared with those who were not. Disclosure and its appropriate implementation should be promoted in pediatric HIV clinics in resource-limited settings. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09540121.2023.2176424
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 1928
    Subjects:
      – SubjectFull: Mortality prevention
        Type: general
      – SubjectFull: HIV infection prognosis
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Disclosure
        Type: general
      – SubjectFull: Evaluation of medical care
        Type: general
      – SubjectFull: Disease progression
        Type: general
      – SubjectFull: Patient aftercare
        Type: general
      – SubjectFull: Combination drug therapy
        Type: general
      – SubjectFull: Antiretroviral agents
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      – SubjectFull: Patient compliance
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      – SubjectFull: Psychology of HIV-positive persons
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      – SubjectFull: Child mortality
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      – SubjectFull: Children
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      – SubjectFull: Adolescence
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      – SubjectFull: Asia
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