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Does the rapid initiation of antiretroviral therapy at HIV diagnosis impact virological response in a real-life setting? A single-centre experience in Northern Italy.

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Title: Does the rapid initiation of antiretroviral therapy at HIV diagnosis impact virological response in a real-life setting? A single-centre experience in Northern Italy.
Authors: Gregori, Natalia, Renzetti, Stefano, Izzo, Ilaria, Faletti, Giulio, Fumarola, Benedetta, degli Antoni, Melania, Arsuffi, Stefania, Storti, Samuele, Tiecco, Giorgio, Calza, Stefano, Caruso, Arnaldo, Castelli, Francesco, Quiros-Roldan, Eugenia, Focà, Emanuele
Source: AIDS Care. Dec2023, Vol. 35 Issue 12, p1938-1947. 10p.
Subjects: Diagnosis of HIV infections, HIV infections, Anti-HIV agents, Drug efficacy, Scientific observation, Viral load, Retrospective studies, Highly active antiretroviral therapy, Treatment effectiveness, Descriptive statistics, Early medical intervention, Patient safety, Proportional hazards models
Geographic Terms: Italy
Abstract: Rapid initiation of antiretroviral therapy (ART) has been proven efficacious and safe, but more investigations are needed to define feasibility of rapid ART approach in real-life settings.We conducted a retrospective, observational study on newly HIVdiagnosed patients referred to our Infectious Diseases Department from September 1st, 2015, to July 31st, 2019. According to the timing of ART initiation, we distinguished 3 groups of patients (rapid, intermediate and late group) and represented the trend of virological response during a 400-days-period. The hazard ratios of each predictor on viral suppression were estimated through the Cox proportional hazard model.The median time from HIV diagnosis to the first medical referral was 15 days and the median time from the first care access to therapy start was 24 days. Among patients, 37.6% started ART within 7 days, 20.6% between 8 and 30 days, and 41.8% after 30 days. Longer time to ART start and higher baseline viral load were associated with a lower probability of viral suppression. After one year, all groups showed a high viral suppression rate (99%). In a high-income setting the rapid ART approach seems useful to accelerate viral suppression which is great over time regardless of ART initiation timing. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Does the rapid initiation of antiretroviral therapy at HIV diagnosis impact virological response in a real-life setting? A single-centre experience in Northern Italy.
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  Data: <searchLink fieldCode="AR" term="%22Gregori%2C+Natalia%22">Gregori, Natalia</searchLink><br /><searchLink fieldCode="AR" term="%22Renzetti%2C+Stefano%22">Renzetti, Stefano</searchLink><br /><searchLink fieldCode="AR" term="%22Izzo%2C+Ilaria%22">Izzo, Ilaria</searchLink><br /><searchLink fieldCode="AR" term="%22Faletti%2C+Giulio%22">Faletti, Giulio</searchLink><br /><searchLink fieldCode="AR" term="%22Fumarola%2C+Benedetta%22">Fumarola, Benedetta</searchLink><br /><searchLink fieldCode="AR" term="%22degli+Antoni%2C+Melania%22">degli Antoni, Melania</searchLink><br /><searchLink fieldCode="AR" term="%22Arsuffi%2C+Stefania%22">Arsuffi, Stefania</searchLink><br /><searchLink fieldCode="AR" term="%22Storti%2C+Samuele%22">Storti, Samuele</searchLink><br /><searchLink fieldCode="AR" term="%22Tiecco%2C+Giorgio%22">Tiecco, Giorgio</searchLink><br /><searchLink fieldCode="AR" term="%22Calza%2C+Stefano%22">Calza, Stefano</searchLink><br /><searchLink fieldCode="AR" term="%22Caruso%2C+Arnaldo%22">Caruso, Arnaldo</searchLink><br /><searchLink fieldCode="AR" term="%22Castelli%2C+Francesco%22">Castelli, Francesco</searchLink><br /><searchLink fieldCode="AR" term="%22Quiros-Roldan%2C+Eugenia%22">Quiros-Roldan, Eugenia</searchLink><br /><searchLink fieldCode="AR" term="%22Focà%2C+Emanuele%22">Focà, Emanuele</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+HIV+infections%22">Diagnosis of HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-HIV+agents%22">Anti-HIV agents</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+load%22">Viral load</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Highly+active+antiretroviral+therapy%22">Highly active antiretroviral therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Early+medical+intervention%22">Early medical intervention</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+safety%22">Patient safety</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink>
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  Data: Rapid initiation of antiretroviral therapy (ART) has been proven efficacious and safe, but more investigations are needed to define feasibility of rapid ART approach in real-life settings.We conducted a retrospective, observational study on newly HIVdiagnosed patients referred to our Infectious Diseases Department from September 1st, 2015, to July 31st, 2019. According to the timing of ART initiation, we distinguished 3 groups of patients (rapid, intermediate and late group) and represented the trend of virological response during a 400-days-period. The hazard ratios of each predictor on viral suppression were estimated through the Cox proportional hazard model.The median time from HIV diagnosis to the first medical referral was 15 days and the median time from the first care access to therapy start was 24 days. Among patients, 37.6% started ART within 7 days, 20.6% between 8 and 30 days, and 41.8% after 30 days. Longer time to ART start and higher baseline viral load were associated with a lower probability of viral suppression. After one year, all groups showed a high viral suppression rate (99%). In a high-income setting the rapid ART approach seems useful to accelerate viral suppression which is great over time regardless of ART initiation timing. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=173451957
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/09540121.2023.2176425
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 1938
    Subjects:
      – SubjectFull: Diagnosis of HIV infections
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Anti-HIV agents
        Type: general
      – SubjectFull: Drug efficacy
        Type: general
      – SubjectFull: Scientific observation
        Type: general
      – SubjectFull: Viral load
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Highly active antiretroviral therapy
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Early medical intervention
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      – SubjectFull: Patient safety
        Type: general
      – SubjectFull: Proportional hazards models
        Type: general
      – SubjectFull: Italy
        Type: general
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              Text: Dec2023
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